Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Hooda Said"'
Autor:
Manuel J. Carrasco, Suman Alishetty, Mohamad-Gabriel Alameh, Hooda Said, Lacey Wright, Mikell Paige, Ousamah Soliman, Drew Weissman, Thomas E. Cleveland, Alexander Grishaev, Michael D. Buschmann
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Carrasco et al. report a method that can predict the lipid nanoparticles (LNP) pKa from the structure of the ionizable lipid. They investigate the delivery efficiency for intramuscular and intravascular administration and propose design principles to
Externí odkaz:
https://doaj.org/article/bbdbf3686db74c9385304e3b47673ec7
Autor:
Haydn L. Ball, Hooda Said, Karen Chapman, Riqiang Fu, Yawei Xiong, Joshua A. Burk, Daniel Rosenbaum, Remi Veneziano, Myriam L. Cotten
Publikováno v:
Biophysical Chemistry. 297:107007
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf7696204e4f7a7d2c694d5b0ec1c6e
https://doi.org/10.1016/j.bpc.2023.107007
https://doi.org/10.1016/j.bpc.2023.107007
Autor:
Manuel J. Carrasco, Tomaz B. Manzoni, Suman Alishetty, Hooda Said, Paul Bates, Philip Hicks, Thomas E. Cleveland, Farhang Alem, Aarthi Narayanan, Drew Weissman, Ousamah Younoss Soliman, Mikell Paige, Patrick Gillevet, Alexander Grishaev, Keziah Hernandez, Mohamad-Gabriel Alameh, Michael D. Buschmann, Lacey Wright, Alisa Stephens-Shields
Concerns with current mRNA Lipid Nanoparticle (LNP) systems include dose-limiting reactogenicity, adverse events that may be partly due to systemic off target expression of the immunogen, and a very limited understanding of the mechanisms responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a3f29d0d19842ce51561cac8844acab
https://doi.org/10.21203/rs.3.rs-798453/v1
https://doi.org/10.21203/rs.3.rs-798453/v1
Autor:
Michael D. Buschmann, Thomas E. Cleveland, Drew Weissman, Hooda Said, Suman Alishetty, Alexander Grishaev, Lacey Wright, Ousamah Younoss Soliman, Manuel J. Carrasco, Mikell Paige, Mohamad-Gabriel Alameh
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Lipid Nanoparticles (LNPs) are used to deliver siRNA and COVID-19 mRNA vaccines. The main factor known to determine their delivery efficiency is the pKa of the LNP containing an ionizable lipid. Herein, we report a method that can predict the LNP pKa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38555c1b6563ec824d49a9b2b4676d6
https://pubmed.ncbi.nlm.nih.gov/34381159
https://pubmed.ncbi.nlm.nih.gov/34381159