Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain [v1; ref status: indexed, http://f1000r.es/1mg]

Autor: Lara Kaddoum, Nicolas Panayotis, Honoré Mazarguil, Giuseppina Giglia-Mari, Jean Christophe Roux, Etienne Joly

Publikováno v: F1000Research, Vol 2 (2013)

Rett syndrome is a neurological disorder caused by mutations in the MECP2 gene. MeCP2 transcripts are alternatively spliced to generate two protein isoforms (MeCP2_e1 and MeCP2_e2) that differ at their N-termini. Whilst mRNAs for both forms are expre

Externí odkaz: https://doaj.org/article/a008173a218e4365b87b155d5cdab176

Description of the low-affinity interaction between nociceptin and the second extracellular loop of its receptor by fluorescence and NMR spectroscopies

Autor: Pascal Demange, Brice Bes, Alain Milon, Lionel Moulédous, Honoré Mazarguil, Jean-Claude Meunier, Bruno Vincent

Publikováno v: Journal of Peptide Science. 14:1183-1194

The second extracellular loop (ECL2) of the Noc receptor has been proposed to be involved in ligand binding and selectivity. The interaction of Noc with a constrained cyclic synthetic peptide, mimicking the ECL2, has been studied using fluorescence a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d5cf2439fd0d452231672dee0bc297
https://doi.org/10.1002/psc.1057

Zinc(II) binds to the neuroprotective peptide humanin

Autor: Ambar Armas, Emmanuelle Mothes, Vanessa Sonois, Peter Faller, Honoré Mazarguil

Publikováno v: Journal of Inorganic Biochemistry. 100:1672-1678

The abnormal accumulation of the peptide amyloid-beta in the form of senile (or amyloid) plaques is one of the hallmarks of Alzheimer's disease (AD). Zinc ions have been implicated in AD and plaques formation. Recently, the peptide humanin has been d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b2c5fc75fb7d6acee3e207450c6ce0
https://doi.org/10.1016/j.jinorgbio.2006.06.002

Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [125I]EYF as selective radioligands

Autor: Catherine Mollereau, Christine Gouardères, Isabelle Quelven, S.Q.J Rice, Jean-Marie Zajac, Honoré Mazarguil

Publikováno v: Neuroscience. 115:349-361

The selectivity of two new radioligands, [ 125 I]YVP ([ 125 I]YVPNLPQRF-NH 2 ) and [ 125 I]EYF ([ 125 I]EYWSLAAPQRF-NH 2 ), for neuropeptide FF (NPFF) receptor subtypes was determined using HEK293 cells expressing hNPFF 1 and CHO cells expressing hNP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05d96d26498869410f407680060fd97
https://doi.org/10.1016/s0306-4522(02)00419-0

Apelin (65–77) Activates Extracellular Signal-Regulated Kinases via a PTX-Sensitive G Protein

Autor: Bernard Masri, Bernard Knibiehler, Honoré Mazarguil, Hicham Lahlou, Yves Audigier

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2002, 290 (1), pp.539-545. ⟨10.1006/bbrc.2001.6230⟩

We report here that apelin (65–77) induces activation of extracellular-regulated kinases (ERKs) in Chinese hamster ovary (CHO) cells expressing the msr/apj receptor. This concentration-dependent activation was transient, peaking at 5 min. Pretreatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f274f696207ad1cee7f3199b63295a9
https://doi.org/10.1006/bbrc.2001.6230