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In Vitro and In Vivo Efficacies of the Linear and the Cyclic Version of an All-d-Enantiomeric Peptide Developed for the Treatment of Alzheimer's Disease

Autor: Schemmert, Sarah, Camargo, Luana Cristina, Honold, Dominik, Gering, Ian, Kutzsche, Janine, Willuweit, Antje, Willbold, Dieter

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 12
International Journal of Molecular Sciences, Vol 22, Iss 6553, p 6553 (2021)
International journal of molecular sciences 22(12), 6553-(2021). doi:10.3390/ijms22126553

Multiple sources of evidence suggest that soluble amyloid β (Aβ)-oligomers are responsible for the development and progression of Alzheimer’s disease (AD). In order to specifically eliminate these toxic Aβ-oligomers, our group has developed a va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::43a642286312a3d37dbbac0b4b23a28f
https://pubmed.ncbi.nlm.nih.gov/34207233

Comprehensive Characterization of the Pyroglutamate Amyloid-β Induced Motor Neurodegenerative Phenotype of TBA2.1 Mice

Autor: Dunkelmann, Tina, Schemmert, Sarah, Willuweit, Antje, Honold, Dominik, Teichmann, Kerstin, Butzküven, Elke, Demuth, Hans-Ulrich, Shah, N. J., Langen, Karl-Josef, Kutzsche, Janine, Willbold, Dieter

Publikováno v: Journal of Alzheimer's Disease
Journal of Alzheimer's disease 63(1), 115-130 (2018). doi:10.3233/JAD-170775

Alzheimer’s disease (AD) is the most common neurodegenerative disorder and is being intensively investigated using a broad variety of animal models. Many of these models express mutant versions of human amyloid-β protein precursor (AβPP) that are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dec3acec2322c3ee38f0882be3a6513b
https://pubmed.ncbi.nlm.nih.gov/29578479

Comprehensive Characterization of the Pyroglutamate Amyloid-v Induced Motor Neurodegenerative Phenotype of TBA2.1 Mice

Autor: Dunkelmann, Tina, Schemmert, Sarah, Honold, Dominik, Teichmann, Kerstin, Butzküven, Elke, Demuth, Hans-Ulrich, Shah, Nadim Joni, Langen, Karl-Josef, Kutzsche, Janine, Willbold, Dieter, Willuweit, Antje

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is being intensively investigated using a broad variety of animal models. Many of these models express mutant versions of human amyloid-v protein precursor (AvPP) that are ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::21101f7bfbcd2eb29b4fcbed2e192f2e
https://publica.fraunhofer.de/handle/publica/261739