Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Honoka, Obata"'
Autor:
Honoka Obata, Atsushi B. Tsuji, Hitomi Sudo, Aya Sugyo, Kaori Hashiya, Hayato Ikeda, Masatoshi Itoh, Katsuyuki Minegishi, Kotaro Nagatsu, Mikako Ogawa, Toshikazu Bando, Hiroshi Sugiyama, Ming-Rong Zhang
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1526 (2023)
Auger electrons can cause nanoscale physiochemical damage to specific DNA sites that play a key role in cancer cell survival. Radio-Pt is a promising Auger-electron source for damaging DNA efficiently because of its ability to bind to DNA. Considerin
Externí odkaz:
https://doaj.org/article/7b0fd990ebf344c784859ad2da6d2d2a
Autor:
Kuan Hu, Xiaohui Ma, Lin Xie, Yiding Zhang, Masayuki Hanyu, Honoka Obata, Lulu Zhang, Kotaro Nagatsu, Hisashi Suzuki, Rui Shi, Weizhi Wang, Ming-Rong Zhang
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 334-341 (2021)
Externí odkaz:
https://doaj.org/article/d7f94abccfe745548c166f28b71d24cf
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1926 (2023)
The present review aims to explore the potential targets/partners for future targeted radionuclide therapy (TRT) strategies, wherein cancer cells often are not killed effectively, despite receiving a high average tumor radiation dose. Here, we shall
Externí odkaz:
https://doaj.org/article/984322d0343e4795805886c777805002
Autor:
Yoshifumi Shirakami, Tadashi Watabe, Honoka Obata, Kazuko Kaneda, Kazuhiro Ooe, Yuwei Liu, Takahiro Teramoto, Atsushi Toyoshima, Atsushi Shinohara, Eku Shimosegawa, Jun Hatazawa, Koichi Fukase
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Astatine-211 (211At)-labeled phenylalanine is expected to be a promising agent for targeted alpha-particle therapy for the treatment of patients with glioma. The existing reactions to prepare the labeled compound usually require organic solv
Externí odkaz:
https://doaj.org/article/c725b93b6496492c9ff9377e5a3890d6
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract We developed a novel method for production of no-carrier-added (n.c.a.) [188, 189, 191Pt]PtIICl4 2− from an Ir target material, and then synthesized n.c.a. [*Pt]cis-[PtIICl2(NH3)2] ([*Pt]cisplatin) from [*Pt]PtIICl4 2−. [*Pt]PtIICl4 2−
Externí odkaz:
https://doaj.org/article/d10f18828228444fa0a80f935dffe1f7
Autor:
Honoka, Obata, Atsushi B, Tsuji, Hitomi, Sudo, Aya, Sugyo, Katsuyuki, Minegishi, Kotaro, Nagatsu, Mikako, Ogawa, Ming-Rong, Zhang
Publikováno v:
Nuclear Medicine Communications. 43:1121-1127
The platinum-based antineoplastic drug cisplatin is commonly used for chemotherapy in clinics. This work aims to demonstrate a radio-platinum tracer is useful for precisely quantifying small amounts of platinum in pharmacokinetics studies.A cisplatin
Autor:
Honoka, Obata, Atsushi B, Tsuji, Katsushi, Kumata, Hitomi, Sudo, Katsuyuki, Minegishi, Kotaro, Nagatsu, Hideo, Takakura, Mikako, Ogawa, Akihiro, Kurimasa, Ming-Rong, Zhang
Publikováno v:
Journal of medicinal chemistry. 65(7)
This study aims to establish new labeling methods for no-carrier-added radio-Pt (
Autor:
Honoka Obata, Atsushi B. Tsuji, Hitomi Sudo, Aya Sugyo, Katsuyuki Minegishi, Kotaro Nagatsu, Mikako Ogawa, Ming-Rong Zhang
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4622 (2021)
Due to their short-range (2–500 nm), Auger electrons (Auger e−) have the potential to induce nano-scale physiochemical damage to biomolecules. Although DNA is the primary target of Auger e−, it remains challenging to maximize the interaction be
Externí odkaz:
https://doaj.org/article/8c82097bb9d84cd28fe97df478ad0168
Publikováno v:
Radiochimica Acta. 110:751-763
National Institutes for Quantum Science and Technology (QST), formerly known as the National Institute of Radiological Sciences (NIRS), has been engaged in work on radiopharmaceutical science using cyclotrons since 1974. Eight pioneering researchers
Development of Novel 191Pt-Labeled Hoechst33258: 191Pt Is More Suitable than 111In for Targeting DNA
Autor:
Honoka Obata, Atsushi B. Tsuji, Katsushi Kumata, Hitomi Sudo, Katsuyuki Minegishi, Kotaro Nagatsu, Hideo Takakura, Mikako Ogawa, Akihiro Kurimasa, Ming-Rong Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:5690-5700