Synaptic loss and its association with symptom severity in Parkinson’s disease

Autor: Sophie E. Holmes, Praveen Honhar, Sule Tinaz, Mika Naganawa, Ansel T. Hilmer, Jean-Dominique Gallezot, Mark Dias, Yanghong Yang, Takuya Toyonaga, Irina Esterlis, Adam Mecca, Christopher Van Dyck, Shannan Henry, Jim Ropchan, Nabeel Nabulsi, Elan D. Louis, Robert Comley, Sjoerd J. Finnema, Richard E. Carson, David Matuskey

Publikováno v: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)

Abstract Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise in imaging loss of synapses in PD

Externí odkaz: https://doaj.org/article/f8c1054730b44122933ba28992365acc

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Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [ ¹⁸ F]FE-PE2I PET: independent validation with new insights.

Autor: Honhar P; Department of Biomedical Engineering, Yale School of Engineering and Applied Sciences, Yale University, New Haven, CT 06511, USA.; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Ebrahimian Sadabad F; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Tinaz S; Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA., Gallezot JD; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Dias M; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Naganawa M; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Yang Y; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Henry S; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Hillmer AT; Department of Biomedical Engineering, Yale School of Engineering and Applied Sciences, Yale University, New Haven, CT 06511, USA.; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA.; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA., Gao H; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Najafzadeh S; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Comley R; AbbVie, North Chicago, IL 60064, USA., Nabulsi N; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Huang Y; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Finnema SJ; AbbVie, North Chicago, IL 60064, USA., Carson RE; Department of Biomedical Engineering, Yale School of Engineering and Applied Sciences, Yale University, New Haven, CT 06511, USA.; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA., Matuskey D; Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA.; Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA.; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA.

Publikováno v: Brain communications [Brain Commun] 2024 Oct 02; Vol. 6 (5), pp. fcae345. Date of Electronic Publication: 2024 Oct 02 (Print Publication: 2024).