Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Hongzhuan, Chen"'
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-24 (2024)
Abstract Background Persistent innate and adaptive immune responses in the brain contribute to the progression of Alzheimer’s disease (AD). APOE4, the most important genetic risk factor for sporadic AD, encodes apolipoprotein E4, which by itself is
Externí odkaz:
https://doaj.org/article/14905b7d5e394e13a78759243af56b53
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Alzheimer’s disease (AD), characterized by cognitive decline, is increasingly recognized as a disorder marked by synaptic loss and dysfunction. Despite this understanding, the underlying pathophysiological mechanisms contributing to synapt
Externí odkaz:
https://doaj.org/article/e360ea0b1301451bb6a7f7c9c75732d6
Autor:
Xiaokun Zhang, Ye Wu, Jiayi Lin, Shengxin Lu, Xinchen Lu, Aoyu Cheng, Hongzhuan Chen, Weidong Zhang, Xin Luan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 3818-3833 (2024)
Immunotherapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer therapy. As vital biological mediators, peptides with high tissue penetration and superior selectivity offer significant promise for e
Externí odkaz:
https://doaj.org/article/4e96d6cb0559410681783ee1a600fbe2
Autor:
Huiting Bian, Xiaohui Liang, Dong Lu, Jiayi Lin, Xinchen Lu, Jinmei Jin, Lijun Zhang, Ye Wu, Hongzhuan Chen, Weidong Zhang, Xin Luan
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract The binding of peroxisome proliferator‐activated receptor γ (PPARγ) to the orphan nuclear receptor Nur77 facilitates the ubiquitination and degradation of Nur77, and leads to aberrant fatty acid uptake for breast cancer progression. Beca
Externí odkaz:
https://doaj.org/article/d8fca0a8e304490cb2ee8883c490cb53
Publikováno v:
Journal of Water and Climate Change, Vol 15, Iss 1, Pp 192-208 (2024)
Based on the daily precipitation data and ERA5 reanalysis data of 40 years from 1981 to 2018 in the middle Yangtze River Valley (MYRV), the climatic characteristics of extreme precipitation are analyzed using statistical methods. The multivariate emp
Externí odkaz:
https://doaj.org/article/a25abb4433294ed284ded748193025f7
Autor:
Kaichun Wang, Yuanyuan Xie, Xixiang Chen, Xiaoyan Ouyang, Lanxue Zhao, Hongzhuan Chen, Jianrong Xu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10432 (2024)
Neuroinflammation is a critical factor that contributes to neurological impairment and is closely associated with the onset and progression of neurodegenerative diseases. In the central nervous system (CNS), microglia play a pivotal role in the regul
Externí odkaz:
https://doaj.org/article/5c567f6649f9487f8bd26faace252c02
Publikováno v:
Journal of Water and Climate Change, Vol 14, Iss 10, Pp 3399-3416 (2023)
Using meteorological analysis, composite analysis and water vapor trajectory analysis, the extreme value rainstorm process in northwest Hunan was analyzed. The results show that three types are summarized: the Southwest Vortex and Warm Shear Line Pat
Externí odkaz:
https://doaj.org/article/49edc73aae174424bcf121e2f8cab2e5
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 2, Pp 347-363 (2023)
Alzheimer’s disease: Protein-activating chili extract improves brain’s immune function A chili pepper extract that activates a sensory protein helps to improve lipid metabolism in immune cells in the brain, leading to better nerve cell health in
Externí odkaz:
https://doaj.org/article/c39b96c014934df5a942797a774cf0bf
Autor:
Ping Li, Chao Gao, Jianping Li, Gang Wang, Xiaoling Gao, Rujing Ren, Ran Tang, Jintao Wang, Xinyi Xie, Shishuang Cui, Jing Chang, Qingxiang Song, Chengxiang Dai, Suke Li, Hongzhuan Chen, Shengdi Chen
Publikováno v:
General Psychiatry, Vol 36, Iss 5 (2023)
Background There have been no effective treatments for slowing or reversing Alzheimer’s disease (AD) until now. Growing preclinical evidence, including this study, suggests that mesenchymal stem cells-secreted exosomes (MSCs-Exos) have the potentia
Externí odkaz:
https://doaj.org/article/208d668f59af4c75b8649b71b84ccf09
Autor:
Dayuan Wang, Xiao Gu, Xinyi Ma, Jun Chen, Qizhi Zhang, Zhihua Yu, Juan Li, Meng Hu, Xiaofang Tan, Yuyun Tang, Jianrong Xu, Minjun Xu, Qingxiang Song, Huahua Song, Gan Jiang, Zaiming Tang, Xiaoling Gao, Hongzhuan Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 2, Pp 834-851 (2023)
Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta, tau, and α-synuclein aggregates in neurodegenerative diseases. However, due to the complex structure and ambiguous pathogenic species of the misfold
Externí odkaz:
https://doaj.org/article/68830f1934e244a9a3427fb520505ffc