Zobrazeno 1 - 10
of 512
pro vyhledávání: '"Hongzhi Li"'
Autor:
Hongzhi Li, Zhuo Chen, Yuqi Shen, Ting Xiong, Andong Chen, Lixia Chen, Yifan Ye, Qingyou Jiang, Yaxi Zhang, Jun Sun, Luxi Shen
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Alzheimer’s disease (AD) is the most common neurogenerative disorder without effective treatments. Defects in mitochondrial complex I are thought to contribute to AD pathogenesis. The aim of this study is to explore whether a no
Externí odkaz:
https://doaj.org/article/42e8b80ef1cf4672ab8f75faf276b54e
Autor:
Hongzhi Li, Jing Zhang, Yuqi Shen, Yifan Ye, Qingyou Jiang, Lan Chen, Bohao Sun, Zhuo Chen, Luxi Shen, Hezhi Fang, Jifeng Yang, Haihua Gu
Publikováno v:
Biological Procedures Online, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), original found in synthetic heroin, causes Parkinson’s disease (PD) in human through its metabolite MPP+ by inhibiting complex I of mitochondrial respiratory chain in dopamine
Externí odkaz:
https://doaj.org/article/15cc9dfaf1134b84a5d90d9c1059b105
Autor:
Meilin Xue, Lei Dong, Honghai Zhang, Yangchan Li, Kangqiang Qiu, Zhicong Zhao, Min Gao, Li Han, Anthony K. N. Chan, Wei Li, Keith Leung, Kitty Wang, Sheela Pangeni Pokharel, Ying Qing, Wei Liu, Xueer Wang, Lili Ren, Hongjie Bi, Lu Yang, Chao Shen, Zhenhua Chen, Laleh Melstrom, Hongzhi Li, Nikolai Timchenko, Xiaolan Deng, Wendong Huang, Steven T. Rosen, Jingyan Tian, Lin Xu, Jiajie Diao, Chun-Wei Chen, Jianjun Chen, Baiyong Shen, Hao Chen, Rui Su
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-24 (2024)
Abstract Background While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains elusive. We aim to c
Externí odkaz:
https://doaj.org/article/b8cac747695b48e59f1516ff7bd9a5a7
Autor:
Yang Wang, Jieyi Wang, Lan Chen, Zhuo Chen, Tong Wang, Shuting Xiong, Tong Zhou, Guang Wu, Licai He, Jiawei Cao, Min Liu, Hongzhi Li, Haihua Gu
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Background Breast cancer is the leading cause of cancer death for women worldwide. Most of the breast cancer death are due to disease recurrence and metastasis. Increasingly accumulating evidence indicates that mitochondria play key roles in
Externí odkaz:
https://doaj.org/article/2c032c06a8e2493097dc9c6dc064819b
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background The circadian clock is an evolutionarily conserved mechanism that exerts pervasive temporal control in stem cell behavior. This time-keeping machinery is required for orchestrating myogenic progenitor properties in regenerative my
Externí odkaz:
https://doaj.org/article/3273f76b4d1d4b1580e4ed67cba00a12
Autor:
Guang Wu, Lan Li, Mengnan Liu, Chunyan Chen, Guangze Wang, Zewei Jiang, Yaqian Qin, Licai He, Hongzhi Li, Jiawei Cao, Haihua Gu
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-14 (2022)
Abstract Background Pancreatic cancer is one of the most aggressive malignancies without effective targeted therapies. MUC1 has emerged as a potential common target for cancer therapy because it is overexpressed in a variety of different cancers incl
Externí odkaz:
https://doaj.org/article/38ecd02b445d47b4a434af9eaac2f9d3
Autor:
Jiawei Zhang, Yichao Gan, Hongzhi Li, Jie Yin, Xin He, Liming Lin, Senlin Xu, Zhipeng Fang, Byung-wook Kim, Lina Gao, Lili Ding, Eryun Zhang, Xiaoxiao Ma, Junfeng Li, Ling Li, Yang Xu, David Horne, Rongzhen Xu, Hua Yu, Ying Gu, Wendong Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
CDK2 can drive the proliferation of cancer cells. Here, the authors screened for a non-ATP competitive inhibitor of the CDK2/cylinA complex and find that Homoharringtonine can disrupt the complex and promote the degradation of CDK2.
Externí odkaz:
https://doaj.org/article/ac83cddd29e447fc91fa01e2387d3f72
Autor:
Hongzhi Li, Bohao Sun, Yuting Huang, Jing Zhang, Xuejing Xu, Yuqi Shen, Zhuo Chen, Jifeng Yang, Luxi Shen, Yongwu Hu, Haihua Gu
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-19 (2022)
Abstract Purpose Parkinson's disease (PD) is the second most common neurodegenerative disease without cure or effective treatment. This study explores whether the yeast internal NADH-quinone oxidoreductase (NDI1) can functionally replace the defectiv
Externí odkaz:
https://doaj.org/article/84f1d8e5dc874853bad119d2a4e99ba0
Publikováno v:
Environmental Challenges, Vol 9, Iss , Pp 100652- (2022)
Diesel engine have been applied to transportation due to its high efficiency, high output power, and high reliability. However, the emissions of diesel engines have become a serious problem and various technologies have been applied to reduce such em
Externí odkaz:
https://doaj.org/article/3edf5dc2ce8948a4b4b5da21078d4d47
Publikováno v:
Sensors, Vol 23, Iss 15, p 6733 (2023)
Energy-efficient and reliable underwater acoustic communication attracts a lot of research due to special marine communication conditions with limited resources in underwater acoustic sensor networks (UASNs). In their final analysis, the existing stu
Externí odkaz:
https://doaj.org/article/22d289b5c36d4aa7853ed0d048dfe87d