Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Hongying Shen"'
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0304453 (2024)
Hirudo nipponia is an important medicinal animal in China. Its salivary gland secretions contain a variety of protein bioactive substances. Investigations of its salivary glands are of great significance in the study of the medicinal value and mechan
Externí odkaz:
https://doaj.org/article/eb118fd40c3f438eb52a4758f20dd332
Autor:
Laura Onuchic, Valeria Padovano, Giorgia Schena, Vanathy Rajendran, Ke Dong, Xiaojian Shi, Raj Pandya, Victoria Rai, Nikolay P. Gresko, Omair Ahmed, TuKiet T. Lam, Weiwei Wang, Hongying Shen, Stefan Somlo, Michael J. Caplan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Mutations in the gene encoding PC1 cause ADPKD, a common genetic renal disease. Here, the authors show that expression of the C-terminal 200 amino acids of the large PC1 protein in mouse models of ADPKD suppresses cystic disease through an interactio
Externí odkaz:
https://doaj.org/article/5169c69bfd7145fcafbf112cbbe1e4dd
Publikováno v:
Buildings, Vol 14, Iss 5, p 1253 (2024)
This study addresses the issue of poor construction labor productivity, exploring the process and methodology for increasing construction workers’ participation in labor productivity improvement, as well as a situational awareness (SA) development
Externí odkaz:
https://doaj.org/article/f9c7c49b1e2147a7af5130cb257a6b74
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Protein phosphorylation is a ubiquitous post-translational modification used to regulate cellular processes and proteome architecture by modulating protein-protein interactions. Here the authors optimize genetically encoded phosphothreonine to study
Externí odkaz:
https://doaj.org/article/4524495ba12546348e670f788fe32025
Autor:
Xiaojian Shi, Bryn Reinstadler, Hardik Shah, Tsz-Leung To, Katie Byrne, Luanna Summer, Sarah E. Calvo, Olga Goldberger, John G. Doench, Vamsi K. Mootha, Hongying Shen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Combinatorial Gene×Gene×Environment CRISPR screen targeting human SLC25 transporter family enables the identification of SLC25A39 in mitochondrial glutathione import and its coordination with mitochondrial iron import in supporting OXPHOS.
Externí odkaz:
https://doaj.org/article/6fe9ef65434e4831b95ba1da4c6f4af7
Publikováno v:
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-7 (2022)
Abstract Background Pulmonary infection is common yet serious complication in patients with severe traumatic brain injury (STBI). We aimed to evaluate the predicators of pulmonary infection in STBI patients undergoing tracheostomy, to provide evidenc
Externí odkaz:
https://doaj.org/article/569e816702b34dbaa3dc4a4b24c9d9b2
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1314 (2023)
Homology search and phylogenetic analysis have commonly been used to annotate gene function, although they are prone to error. We hypothesize that the power of homology search in functional annotation depends on the coupling of sequence variation to
Externí odkaz:
https://doaj.org/article/c38a170bde63445fb691414c0355d717
Publikováno v:
Forensic Sciences Research, Vol 5, Iss 4, Pp 292-299 (2020)
This article describes a newly devised autosomal short tandem repeat (STR) multiplex polymerase chain reaction (PCR) system for 19 autosomal loci (D12S391, D13S317, D16S539, D18S51, D19S433, D2S1338, D21S11, D3S1358, D5S818, D6S1043, D7S820, D8S1179,
Externí odkaz:
https://doaj.org/article/ca94177abce64b4d89468868da48f479
Publikováno v:
Diversity, Vol 14, Iss 9, p 768 (2022)
To investigate the effect of feeding on hibernating Hirudo nipponia, metagenomic sequencing was performed on the microorganisms collected from the digestive tract of H. nipponia individuals that were fed (FW) or starving (SW) before hibernation. In a
Externí odkaz:
https://doaj.org/article/93841b21c9924b3cbe24af78a3d9c023
Autor:
Laura Onuchic, Valeria Padovano, Giorgia Schena, Xiaojian Shi, Ke Dong, Vanathy Rajendran, Victoria Rai, Raj Pandya, Nikolay Gresko, Hongying Shen, Stefan Somlo, Michael Caplan
Publikováno v:
Physiology. 38
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common life-threatening genetic diseases. Mutations in the PKD1 gene, which encodes polycystin-1, account for ~78% of cases. We have previously shown that transgenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f98a1770b9c1c3dfe35a863389e6935d
https://doi.org/10.1152/physiol.2023.38.s1.5731616
https://doi.org/10.1152/physiol.2023.38.s1.5731616