Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hongying Gang"'
Autor:
Rimpy Dhingra, Inna Rabinovich-Nikitin, Sonny Rothman, Matthew Guberman, Hongying Gang, Victoria Margulets, Davinder S. Jassal, Keshav Narayan Alagarsamy, Sanjiv Dhingra, Carla Valenzuela Ripoll, Filio Billia, Abhinav Diwan, Ali Javaheri, Lorrie A. Kirshenbaum
Publikováno v:
Circulation. 146:934-954
Background: Cytokines such as tumor necrosis factor-α (TNFα) have been implicated in cardiac dysfunction and toxicity associated with doxorubicin (DOX). Although TNFα can elicit different cellular responses, including survival or death, the mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee2c93538b6cb4542782bf554a49a2a
https://doi.org/10.1161/circulationaha.121.058411
https://doi.org/10.1161/circulationaha.121.058411
Autor:
Victoria Margulets, Rimpy Dhingra, James A. Thliveris, Lorrie A. Kirshenbaum, Jonathon Gerstein, Matthew Guberman, Inna Rabinovich-Nikitin, Nicholas Madden, Hongying Gang
Publikováno v:
Cardiovascular Research
Aims The chemotherapy drug doxorubicin (Dox) is commonly used for treating a variety of human cancers; however, it is highly cardiotoxic and induces heart failure. We previously reported that the Bcl-2 mitochondrial death protein Bcl-2/19kDa interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428505d031b2eb0ee9acae1fefacda82
https://pubmed.ncbi.nlm.nih.gov/31868877
https://pubmed.ncbi.nlm.nih.gov/31868877
Autor:
Lorrie A Kirshenbaum, Inna Rabinovich-Nikitin, Hongying Gang, Victoria Margulets, Floribeth Aguilar
Publikováno v:
Circulation. 136
Circadian rhythms play a fundamental role in cell metabolism and tissue homeostasis and are influenced by the diurnal oscillation of cellular circadian clock genes. Zeitgebers influence the activation of the circadian rhythm by serving as molecular s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a46f11d5702db871daa4ea463fc0f38
https://doi.org/10.1161/circ.136.suppl_1.20933
https://doi.org/10.1161/circ.136.suppl_1.20933
Autor:
Lorrie A. Kirshenbaum, Rimpy Dhingra, Yaron Aviv, Victoria Margulets, Hongying Gang, Erika Yan Wang
Publikováno v:
Hypertension. 62:70-77
Myocardial ischemia and angiotensin II activate the tumor suppressor p53 protein, which promotes cell death. Previously, we showed that the Bcl-2 death gene Bnip3 is highly induced during ischemia, where it triggers mitochondrial perturbations result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6a7c13ff0435fb6951b2163f7f5d91
https://doi.org/10.1161/hypertensionaha.113.01028
https://doi.org/10.1161/hypertensionaha.113.01028
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 304:H1662-H1669
Gene transcription is regulated by post-translation modifications. Histone deacetylases (HDACs) remove acetyl groups from histone and non-histone factors inhibiting transcription. Proinflammatory cytokines such as TNFα activate the canonical nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9033b5bf00db55f1a4650e863028c6
https://doi.org/10.1152/ajpheart.00093.2013
https://doi.org/10.1152/ajpheart.00093.2013
Publikováno v:
Antioxidants & Redox Signaling. 14:2245-2250
Autophagy is a highly orchestrated cellular process by which proteins and organelles are degraded via an elaborate lysosomal pathway to generate free amino acids and sugars for ATP during metabolic stress. At present, the exact role of autophagy in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb223dc4d8c0bbc29d4cbb381f00b8e
https://doi.org/10.1089/ars.2010.3479
https://doi.org/10.1089/ars.2010.3479
Autor:
Hongying Gang, Rimpy Dhingra, Wajihah Mughal, Joseph W. Gordon, Yan Wang, Lorrie A. Kirshenbaum
Publikováno v:
Pediatric Cardiology. 32:263-266
A delicate balance exists between cell growth and cell death. In the context of the adult myocardium, inappropriate or inordinate cell loss through an apoptotic process may profoundly influence cardiac structure, function, or both given the limited a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85b0ed44096938c284759efe1d408da
https://doi.org/10.1007/s00246-011-9893-z
https://doi.org/10.1007/s00246-011-9893-z
Publikováno v:
Circulation. 132
Alternative splicing provides a versatile mechanism by which cells generate proteins with different or even antagonistic properties. Herein we describe a novel splice variant of the hypoxia-inducible death gene Bnip3. Sequence analysis of the new Bni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd3759b260229d71f637530dc534130d
https://doi.org/10.1161/circ.132.suppl_3.19824
https://doi.org/10.1161/circ.132.suppl_3.19824
Autor:
Hongying Gang, Shetuan Zhang
Publikováno v:
The Journal of General Physiology
The inactivation gating of hERG channels is important for the channel function and drug–channel interaction. Whereas hERG channels are highly selective for K+, we have found that inactivated hERG channels allow Na+ to permeate in the absence of K+.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ffe63423222e6dc95ebe3034917dec
http://europepmc.org/articles/PMC2151557
http://europepmc.org/articles/PMC2151557
Publikováno v:
Circulation Research. 113
Gene transcription is regulated by post-translation modifications. Histone deacetylases (HDACs) remove acetyl-groups from histone and non-histone factors inhibiting transcription. Pro-inflammatory cytokines such as TNFα activate the canonical Nuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d6dba7cb8708219b3546301afba7220
https://doi.org/10.1161/res.113.suppl_1.a268
https://doi.org/10.1161/res.113.suppl_1.a268