Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Hongyan Gou"'
Publikováno v:
Pharmacological Research, Vol 208, Iss , Pp 107373- (2024)
Gastrointestinal cancer is a worldwide health challenge due to its dramatically increasing prevalence and as a leading cause of cancer-related mortality. Increasing evidence has illustrated the vital role of gut microbes-derived metabolites in gastro
Externí odkaz:
https://doaj.org/article/4b4a2dd2ee2643b6877f937d0c90880b
Autor:
Xianyi Zeng, Xiang Zhang, Hao Su, Hongyan Gou, Harry Cheuk-Hay Lau, Xiaoxu Hu, Ziheng Huang, Yan Li, Jun Yu
Publikováno v:
Engineering, Vol 35, Iss , Pp 257-269 (2024)
Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease without effective treatment. The traditional Chinese medicine formulation Pien Tze Huang (PTH) can suppress inflammatory diseases. Here, we evaluate the effect
Externí odkaz:
https://doaj.org/article/4a431b3dfc754b0683a4ae03b8041cb7
Autor:
Qiming Zhou, Yao Peng, Fenfen Ji, Huarong Chen, Wei Kang, Lam-Shing Chan, Hongyan Gou, Yufeng Lin, Pingmei Huang, Danyu Chen, Qinyao Wei, Hao Su, Cong Liang, Xiang Zhang, Jun Yu, Chi Chun Wong
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract KRAS is an important tumor intrinsic factor driving immune suppression in colorectal cancer (CRC). In this study, we demonstrate that SLC25A22 underlies mutant KRAS-induced immune suppression in CRC. In immunocompetent male mice and humanize
Externí odkaz:
https://doaj.org/article/ee931e2b1f17476088741b1651d761a4
Autor:
Xiaohong Wang, Lianhai Zhang, Qiaoyi Liang, Chi Chun Wong, Huarong Chen, Hongyan Gou, Yujuan Dong, Weixin Liu, Ziyu Li, Jiafu Ji, Jun Yu
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-11 (2022)
Abstract We elucidated the functional significance and molecular mechanisms of DUSP5P1 lncRNA (dual specificity phosphatase 5 pseudogene 1) in gastric carcinogenesis. We demonstrated that gastric cancer (GC) patients with high DUSP5P1 expression had
Externí odkaz:
https://doaj.org/article/c330c9d1a1e149519eddec8b2a5aae8e
Autor:
Chi Chun Wong, Jian-Lin Wu, Fenfen Ji, Wei Kang, Xiqing Bian, Huarong Chen, Lam-Shing Chan, Simson Tsz Yat Luk, Samuel Tong, Jiaying Xu, Qiming Zhou, Dabin Liu, Hao Su, Hongyan Gou, Alvin Ho-Kwan Cheung, Ka Fai To, Zongwei Cai, Jerry W. Shay, Jun Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Looking for metabolic-associated vulnerabilities is a promising approach for therapeutic intervention in KRAS-mutant colorectal cancer. Here, the authors show that the cholesterol-uptake regulator PCSK9 drives tumourigenesis and is a therapeutic targ
Externí odkaz:
https://doaj.org/article/b983ec1445e54ade901f9b1e5f30d6ee
Autor:
Huarong Chen, Yasi Pan, Qiming Zhou, Cong Liang, Chi-Chun Wong, Yunfei Zhou, Dan Huang, Weixin Liu, Jianning Zhai, Hongyan Gou, Hao Su, Xiaoting Zhang, Hongzhi Xu, Yifei Wang, Wei Kang, William Ka Kei Wu, Jun Yu
Publikováno v:
Gastroenterology. 163:891-907
Autor:
Jianning Zhai, Huarong Chen, Chi Chun Wong, Yao Peng, Hongyan Gou, Jingwan Zhang, Yasi Pan, Danyu Chen, Yufeng Lin, Shiyan Wang, Wei Kang, Ka Fai To, Zhiwei Chen, Yuqiang Nie, Housheng Hansen He, Joseph Jao-Yiu Sung, Jun Yu
Publikováno v:
Gastroenterology.
Autor:
Jun Yu, Jiafu Ji, Yujuan Dong, Huarong Chen, Ziyu Li, Hongyan Gou, Lianhai Zhang, Qiaoyi Liang, Xiaohong Wang
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d1674f001d28bffbfba927fca4bb2a
https://doi.org/10.1158/1078-0432.22468316
https://doi.org/10.1158/1078-0432.22468316
Autor:
Jun Yu, Jiafu Ji, Yujuan Dong, Huarong Chen, Ziyu Li, Hongyan Gou, Lianhai Zhang, Qiaoyi Liang, Xiaohong Wang
DUSP5P1 promotes GC cell proliferation in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569ea9dd8349ecc0b1156e74be14b8b0
https://doi.org/10.1158/1078-0432.22468319
https://doi.org/10.1158/1078-0432.22468319
Autor:
Jun Yu, Jing-Yuan Fang, Francis K.L. Chan, Joseph J.Y. Sung, Ka-Fai To, Joanna H. Tong, Jiafu Ji, Xiaohong Wang, Rui Li, Yanquan Zhang, Huarong Chen, Lijing Zhang, Jessie Qiaoyi Liang, Hongyan Gou
Copy number alterations are crucial for the development of colorectal cancer. Our whole-genome analysis identified tocopherol alpha transfer protein-like (TTPAL) as preferentially amplified in colorectal cancer. Here we demonstrate that frequent copy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9863eef474dcebf2d0f4505ee72b8bc
https://doi.org/10.1158/0008-5472.c.6510981.v1
https://doi.org/10.1158/0008-5472.c.6510981.v1