Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Hongwu Qian"'
Autor:
Xin Liu, Liu Ye, Ying Ding, Wei Gong, Hongwu Qian, Kai Jin, Yingjie Niu, Qisheng Zuo, Jiuzhou Song, Wei Han, Guohong Chen, Bichun Li
Publikováno v:
Poultry Science, Vol 103, Iss 11, Pp 104140- (2024)
ABSTRACT: Avian primordial germ cells (PGCs) are important culture cells for the production of transgenic chickens and preservation of the genetic resources of endangered species; however, culturing these cells in vitro proves challenging. Although t
Externí odkaz:
https://doaj.org/article/9ba840fc09c841489648e198b8f979f1
Autor:
Mingli Gong, Cheng Peng, Chen Yang, Zhenhua Wang, Hongwu Qian, Xue Hu, Peng Zhou, Chao Shan, Qiang Ding
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/7aece60551a34e76b8433d4bc424a8fc
Autor:
Jingjing He, Guoyun Liu, Fang Kong, Qiulong Tan, Zhenzhou Wang, Meng Yang, Yonglin He, Xiaoxiao Jia, Chuangye Yan, Chao Wang, Hongwu Qian
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114628- (2024)
Summary: High serum urate levels are the major risk factor for gout. URAT1, the primary transporter for urate absorption in the kidneys, is well known as an anti-hyperuricemia drug target. However, the clinical application of URAT1-targeted drugs is
Externí odkaz:
https://doaj.org/article/088af0d6ffd2405baea74943611a6885
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Abstract Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are two primary components of the eukaryotic membrane and play essential roles in the maintenance of membrane integrity, lipid droplet biogenesis, autophagosome formation, and lipopr
Externí odkaz:
https://doaj.org/article/3bb7389fd6db4f9398ac34f10c5e259b
Autor:
Renhong Yan, Pingping Cao, Wenqi Song, Yaning Li, Tongtong Wang, Hongwu Qian, Chuangye Yan, Nieng Yan
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109299- (2021)
Summary: The sterol regulatory element-binding protein (SREBP) pathway monitors the cellular cholesterol level through sterol-regulated association between the SREBP cleavage-activating protein (Scap) and the insulin-induced gene (Insig). Despite str
Externí odkaz:
https://doaj.org/article/efb71d2911cf4aa19eabaf61f1a73461
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (Sh
Externí odkaz:
https://doaj.org/article/fd4815694c8c4fb7b4dd4c78bc0cfff4
Autor:
Hongwu Qian, Ximing Du, Nieng Yan, Xue Sun, Shuai Gao, Xia Yao, Renhong Yan, Xin Zhao, Catherine C. L. Wong, Hongyuan Yang
Publikováno v:
Nature. 581:333-338
As members of the membrane-bound O-acyltransferase (MBOAT) enzyme family, acyl-coenzyme A:cholesterol acyltransferases (ACATs) catalyse the transfer of an acyl group from acyl-coenzyme A to cholesterol to generate cholesteryl ester, the primary form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7b410da07c21e9097ba31f64754afc
https://doi.org/10.1038/s41586-020-2290-0
https://doi.org/10.1038/s41586-020-2290-0
Autor:
Hongwu Qian, Lie Wang, B. V. Venkataram Prasad, Nieng Yan, Ming Zhou, Yimo Han, Liya Hu, Zhenning Ren, Hanzhi Zhang, Yin Nian, Arthur Laganowsky
Publikováno v:
Nature
Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans1. DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea53054651f8310964979501f0e23e96
https://doi.org/10.1038/s41586-020-2280-2
https://doi.org/10.1038/s41586-020-2280-2
Publikováno v:
Trends in biochemical sciences. 47(4)
The sterol-sensing domain (SSD) is present in several membrane proteins that function in cholesterol metabolism, transport, and signaling. Recent progress in structural studies of SSD-containing proteins, such as sterol regulatory element-binding pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0db62fd35e21b7c0a209974f0c10206
https://pubmed.ncbi.nlm.nih.gov/35012873
https://pubmed.ncbi.nlm.nih.gov/35012873
Autor:
Nieng Yan, Qiang Zhou, Jianlin Lei, Hudson W. Coates, Hongyuan Yang, Ximing Liu, Wenqi Song, Shuai Gao, Hongwu Qian, Xin Zhao, Xin Gong, Yaning Li, Pingping Cao, Renhong Yan, Andrew J. Brown, Jianhua Sui, Chuangye Yan, Ximing Du
Publikováno v:
Science (New York, N.Y.). 371(6533)
A cellular cholesterol sensor Cholesterol levels in cells are controlled by the sterol regulatory element–binding protein (SREBP) pathway. When the cell has sufficient cholesterol, the transcription factor that regulates cholesterol metabolism is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0cab616d34502ba129dd50179fc925
https://pubmed.ncbi.nlm.nih.gov/33446483
https://pubmed.ncbi.nlm.nih.gov/33446483