Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hongtian Dong"'
Autor:
Yongtao He, Jiayin Zhao, Yuanyuan Ma, Xin Yan, Yufei Duan, Xiaoshuang Zhang, Hongtian Dong, Rong Fang, Yunhe Zhang, Qing Li, Ping Yang, Mei Yu, Jian Fei, Fang Huang
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-26 (2024)
Abstract Parkinson’s disease (PD) is a prevalent neurodegenerative disorder with indistinct etiology and ill-defined pathophysiology. Intestinal inflammation involved in the pathogenesis of PD, but the underlying mechanism is not fully understood.
Externí odkaz:
https://doaj.org/article/191c4c5f285f4ec4b9e90f50480b6812
Autor:
Hongtian Dong, Xiaoshuang Zhang, Yufei Duan, Yongtao He, Jiayin Zhao, Zishan Wang, Jinghui Wang, Qing Li, Guangchun Fan, Zhaolin Liu, Chenye Shen, Yunhe Zhang, Mei Yu, Jian Fei, Fang Huang
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-25 (2024)
Abstract Neuroinflammation is one of the core pathological features of Parkinson’s disease (PD). Innate immune cells play a crucial role in the progression of PD. Microglia, the major innate immune cells in the brain, exhibit innate immune memory e
Externí odkaz:
https://doaj.org/article/692770e9e37a4b48abf7bca96bf7c00d
Autor:
Zhaolin Liu, Chenye Shen, Heng Li, Jiabin Tong, Yufei Wu, Yuanyuan Ma, Jinghui Wang, Zishan Wang, Qing Li, Xiaoshuang Zhang, Hongtian Dong, Yufang Yang, Mei Yu, Jian Wang, Renyuan Zhou, Jian Fei, Fang Huang
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-21 (2023)
Abstract Parkinson’s disease (PD) is mainly characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and neuroinflammation mediated by overactivated microglia and astrocytes. NLRC5 (nucleoti
Externí odkaz:
https://doaj.org/article/d737bffdd402413a88282475ecf69a39
Autor:
Xiaochen Bai, Jinghui Wang, Xiaoshuang Zhang, Yilin Tang, Yongtao He, Jiayin Zhao, Linlin Han, Rong Fang, Zhaolin Liu, Hongtian Dong, Qing Li, Jingyu Ge, Yuanyuan Ma, Mei Yu, Ruilin Sun, Jian Wang, Jian Fei, Fang Huang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of midbrain dopaminergic neurons. The miR-29s family, including miR-29a and miR-29b1 as well as miR-29b2 and miR-29c, are implicated in aging, metabo
Externí odkaz:
https://doaj.org/article/09fc3643cd364a36b71bd8715a5f1024
Autor:
Jiayin Zhao, Yongtao He, Yufei Duan, Yuanyuan Ma, Hongtian Dong, Xiaoshuang Zhang, Rong Fang, Yunhe Zhang, Mei Yu, Fang Huang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9975 (2023)
Histone deacetylase 6 (HDAC6) is involved in the regulation of protein aggregation and neuroinflammation, but its role in Parkinson’s disease (PD) remains controversial. In this study, Hdac6−/− mice were generated by CRISPR-Cas9 technology for
Externí odkaz:
https://doaj.org/article/ba93accd00cf46729394d8b9de609144
Autor:
Zishan Wang, Hongtian Dong, Jinghui Wang, Yulu Huang, Xiaoshuang Zhang, Yilin Tang, Qing Li, Zhaolin Liu, Yuanyuan Ma, Jiabin Tong, Li Huang, Jian Fei, Mei Yu, Jian Wang, Fang Huang
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
The pathological hallmarks of Parkinson's disease (PD) are the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and the presence of overactivated glial cells and neuroinflammation. Nuclear factor kappa-light-
Externí odkaz:
https://doaj.org/article/5636ed92da3c4549990d28a5025cc45a
Autor:
Huang, Jiayin Zhao, Yongtao He, Yufei Duan, Yuanyuan Ma, Hongtian Dong, Xiaoshuang Zhang, Rong Fang, Yunhe Zhang, Mei Yu, Fang
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9975
Histone deacetylase 6 (HDAC6) is involved in the regulation of protein aggregation and neuroinflammation, but its role in Parkinson’s disease (PD) remains controversial. In this study, Hdac6−/− mice were generated by CRISPR-Cas9 technology for
Autor:
Xiaochen Bai, Mei Yu, Ruilin Sun, Jingyu Ge, Jian Fei, Hongtian Dong, Jinghui Wang, Qing X. Li, Yuanyuan Ma, Zhaolin Liu, Rong Fang, Xiaoshuang Zhang, Fang Huang
Publikováno v:
Aging (Albany NY)
Studies reveal a linkage of miR-29s in aging and Parkinson’s disease (PD). Here we show that the serum levels of miR-29s in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice exhibited dynamic changes. The role of miR-29b2/c in agi
Autor:
Ruilin Sun, Ruling Shen, Jian Fei, Zishan Wang, Chenye Shen, Lei Ci, Mei Yu, Zhaolin Liu, Jinghui Wang, Xiaoshuang Zhang, Fang Huang, Yuanyuan Ma, Hongtian Dong, Qing X. Li
Publikováno v:
Cell Proliferation
Objectives Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive and selective degeneration of dopaminergic neurons. Microglial activation and neuroinflammation are associated with the pathogenesis of PD. Ho
Autor:
Mei Yu, Mo Wang, Hongtian Dong, Di Yun, Fang Huang, Dongxue Li, Xiaoshuang Zhang, Qing X. Li, Jinghui Wang, Jian Fei, Zhaolin Liu, Thomas Behnisch, Rong Fang, Zishan Wang, Yufang Yang, Chenye Shen
Publikováno v:
SSRN Electronic Journal.
NRSF/REST plays an important role in the neuronal homeostasis as a transcriptional repressor of neuronal genes. NRSF/REST has been linked to cognitive preservation and longevity of humans, but its specific functions in age-dependent and Alzheimer's d