Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Hongshun Shi"'
PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation
Autor:
Hongshun Shi, Hui Li, Ronghua Yuan, Wen Guan, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Fang Tong, Li Li, Zhihong Song, Changwei Wang, Shulan Yang, Haihe Wang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-18 (2018)
Abstract Background Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumor
Externí odkaz:
https://doaj.org/article/8a72b1a946334070be15bd5ee31190fc
Autor:
Zhuoyuan Lin, Shivani Agarwal, Song Tan, Hongshun Shi, Xiaodong Lu, Zhipeng Tao, Xuesen Dong, Xu Wu, Jonathan C. Zhao, Jindan Yu
Publikováno v:
Oncogene.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad24ce892c110c6267c04522eb1f5291
https://doi.org/10.1038/s41388-023-02718-2
https://doi.org/10.1038/s41388-023-02718-2
PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation
Autor:
Wen Guan, Hui Li, Hongshun Shi, Zhihong Song, Li Li, Changwei Wang, Fang Tong, Xiaomei Zhang, Wenliang Zhang, Shaoyang Zhang, Ronghua Yuan, Haihe Wang, Shulan Yang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-18 (2018)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005e4e4a016f7a1363cfd4f2dd2da08e
http://link.springer.com/article/10.1186/s13046-018-0840-1
http://link.springer.com/article/10.1186/s13046-018-0840-1
Publikováno v:
International Journal of Heat and Technology. 35:398-402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e523a2767e96da4359d0d0f9e410a107
https://doi.org/10.18280/ijht.350224
https://doi.org/10.18280/ijht.350224
Autor:
Hongshun Shi, Bin Liu, Shulan Yang, Guoliang Liu, Wenliang Zhang, Fang Tong, Mingming Zhang, Shuai Mao, Li Li, Haihe Wang
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 73:127-136
Accumulating evidences indicate that poly C binding protein (PCBP1) is downregulated in various carcinomas as a tumor suppressor, but the underlying mechanism in suppression of tumorigenesis still remains elusive. Here, we found that PCBP1 overexpres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e8b2b00ad77a540cd46aa33c517823
https://doi.org/10.1016/j.biocel.2016.02.009
https://doi.org/10.1016/j.biocel.2016.02.009
Autor:
Shulan Yang, Wenliang Zhang, Mingming Zhang, Junyi Zhou, Fang Tong, Li Li, Xiaoling Guo, Hongshun Shi, Haihe Wang
Publikováno v:
International Journal of Oncology. 48:1541-1552
The metastasis-associated phosphatase of regenerating liver-3 (PRL-3) plays multiple roles in progression of various human cancers; however, significance of its role during development has not been addressed. Here we cloned and characterized the expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb4ccc69ec31fa81965369654ac577a
https://doi.org/10.3892/ijo.2016.3363
https://doi.org/10.3892/ijo.2016.3363
Autor:
Hongshun Shi, Li, Hui, Ronghua Yuan, Guan, Wen, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Tong, Fang, Li, Li, Zhihong Song, Changwei Wang, Shulan Yang, Haihe Wang
Figure S4. Colonies induced by A2780 or DLD-1 cells overexpressing PCBP1. PCBP1, PCBP1-p27 KD and GFP control cells were analyzed by soft agar assay for anchorage-independent growth. Colonies were stained with Trypan Blue and photographed. (PPT 609 k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c025691e3af323010eb5ed8e583e18e
Autor:
Hongshun Shi, Li, Hui, Ronghua Yuan, Guan, Wen, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Tong, Fang, Li, Li, Zhihong Song, Changwei Wang, Shulan Yang, Haihe Wang
Figure S7. Expression of PCBP1 and p27 in ovary cancer samples compared to that in the normal tissues. The indicated protein expression level was defined based on the staining intensity under the same robust IHC staining condition. (PPT 1277 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1453fa2f8ca05b3718a7dd6890748439
Autor:
Hongshun Shi, Li, Hui, Ronghua Yuan, Guan, Wen, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Tong, Fang, Li, Li, Zhihong Song, Changwei Wang, Shulan Yang, Haihe Wang
Figure S1. PCBP1 increased p27 mRNA stability in A2780, DLD-1 and MDA-MB-231 cells. (A). Schematic procedure of isolation and identification of PCBP1-bound RNA transcripts. (B). Semi-quantitative RT-PCR detection of p27 mRNA levels in the indicated c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e9c9721a815dd665687a1bdefcd313
Autor:
Hongshun Shi, Li, Hui, Ronghua Yuan, Guan, Wen, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Tong, Fang, Li, Li, Zhihong Song, Changwei Wang, Shulan Yang, Haihe Wang
Figure S10. A positive correlation between PCBP1 and p27 proteinlevels in human renal cancer samples. (B) Relationship between PCBP1 and p27 protein expression in IHC staining. A positive correlation between PCBP1 and p27 protein levels is observed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637892637913f74dd7f73540137ce900