Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hongshuang Qin"'
Autor:
Hongshuang Qin, Yanxiang Guo
Publikováno v:
ACS omega. 7(34)
Salinomycin exhibits significant systemic adverse reactions such as tachycardia and myoglobinuria in mammals, which hinders its application as a drug for human cancers. Although many strategies aimed at increasing salinomycin's toxicity to cancer cel
Publikováno v:
Angewandte Chemie International Edition. 61
Even a well-designed system can only control stem cell adhesion, release, and differentiation, while other cell manipulations such as in situ labeling and retention in target tissues, are difficult to achieve in the same system. Herein, native ligand
Autor:
Xiaogang Qu, Yuhuan Sun, Hongshuang Qin, Jinsong Ren, Chuanqi Zhao, Jingsheng Niu, Tingting Cui
Publikováno v:
Nucleic Acids Research
Telomeric DNA, whose length homeostasis is closely correlated with immortality of cancer cells, is regarded as a molecular clock for cellular lifespan. Regarding the capacity in forming G-quadruplex, G-rich 3′-overhang (G-overhang) has been conside
Publikováno v:
Nano letters. 21(17)
Cancer stem cells (CSCs) play crucial roles in tumor initiation. Amyloid β (Aβ), which is associated with Alzheimer's disease (AD), has been identified to induce cytotoxicity in tumor cells besides brain cells. Herein, we find that oligomeric Aβ1-
Autor:
Chaoqun Liu, Huan Wang, Jinsong Ren, Lihua Kang, Hao Qiu, Xiaogang Qu, Zhaowei Chen, Hongshuang Qin
Publikováno v:
Journal of materials chemistry. B. 6(47)
Photodynamic therapy (PDT) has been widely used as a noninvasive and moderate technique in precision cancer therapy by destroying cancer cells via light-induced reactive oxygen species (ROS). However, the overproduction of heat shock protein 70 (HSP7
Publikováno v:
Angewandte Chemie. 130:11352-11357
The effective guidance of mesenchymal stem cell (MSC) differentiation on a substrate by near-infrared (NIR) light is particularly attractive for tissue engineering and regenerative medicine. However, most of current substrates cannot control multidir
Publikováno v:
Chemistry - A European Journal. 23:11226-11229
Telomerase is a key regulator in cell metabolism, tissue renewal, and organismal lifespan. Here we develop a simple strategy to modulate cellular telomerase activity, and further control cell fate based on Mg2+ - and Zn2+ -activated DNAzymes in livin
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 15(42)
Nanodrug-based cancer therapy is impeded by poor penetration into deep tumor tissues mainly due to the overexpression of hyaluronic acid (HA) in the tumor extracellular matrix (ECM). Although modification of nanoparticles (NPs) with hyaluronidase (HA
Autor:
Zhenbo Song, Yongli Bao, Yuxin Li, Jiawei Li, Lihua Zheng, Luguo Sun, Chunxue Niu, Huihan Ai, Hongshuang Qin
Publikováno v:
Biochemical Pharmacology. 177:113984
Pluripotent stem cells are have therapeutic applications in regenerative medicine and drug discovery. However, the differentiation of stem cells in vitro hinders their large-scale production and clinical applications. The maintenance of cell pluripot
Publikováno v:
Advanced Therapeutics. 3:1900203