Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Hongshan Guo"'
Autor:
Tianyun Zhang, Hanying Jia, Tairan Song, Lin Lv, Doga C. Gulhan, Haishuai Wang, Wei Guo, Ruibin Xi, Hongshan Guo, Ning Shen
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Identifying expressed somatic mutations from single-cell RNA sequencing data de novo is challenging but highly valuable. We propose RESA – Recurrently Expressed SNV Analysis, a computational framework to identify expressed somatic mutation
Externí odkaz:
https://doaj.org/article/ad06594af069403b885f96af7a6cbad2
Autor:
Douglas B. Fox, Richard Y. Ebright, Xin Hong, Hunter C. Russell, Hongshan Guo, Thomas J. LaSalle, Ben S. Wittner, Nicolas Poux, Joanna A. Vuille, Mehmet Toner, Nir Hacohen, Genevieve M. Boland, Debattama R. Sen, Ryan J. Sullivan, Shyamala Maheswaran, Daniel A. Haber
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-7 (2023)
Abstract Immune checkpoint blockade (ICB) has demonstrated efficacy in patients with melanoma, but many exhibit poor responses. Using single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs) and functional characterizatio
Externí odkaz:
https://doaj.org/article/0c4c7c44430b4c2d974ab834570483bb
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
Autor:
Satoru Matsuda, Ajinkya Revandkar, Taronish D. Dubash, Arvind Ravi, Ben S. Wittner, Maoxuan Lin, Robert Morris, Risa Burr, Hongshan Guo, Karsen Seeger, Annamaria Szabolcs, Dante Che, Linda Nieman, Gad A. Getz, David T. Ting, Michael S. Lawrence, Justin Gainor, Daniel A. Haber, Shyamala Maheswaran
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112129- (2023)
Summary: TGF-β induces senescence in embryonic tissues. Whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influen
Externí odkaz:
https://doaj.org/article/d7cf1d03230041eaa0fc9ddd6ef3a6cf
Autor:
Ken Tajima, Satoru Matsuda, Toshifumi Yae, Benjamin J. Drapkin, Robert Morris, Myriam Boukhali, Kira Niederhoffer, Valentine Comaills, Taronish Dubash, Linda Nieman, Hongshan Guo, Neelima K. C. Magnus, Nick Dyson, Toshihiro Shioda, Wilhelm Haas, Daniel A. Haber, Shyamala Maheswaran
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
SETD1A, a histone H3K4 methyltransferase that promotes gene expression, is required for embryonic development. Here, the authors show that SETD1A regulates the expression of mitotic genes and that SETD1A suppression induces senescence.
Externí odkaz:
https://doaj.org/article/21e385ead60048f085bedca5bc235b72
Publikováno v:
Data in Brief, Vol 30, Iss , Pp 105192- (2020)
To better understand the extent of how the air temperature and mean radiant temperature may vary both spatially and temporally in a radiantly heated space, we conducted a seven-day experiment in the architectural laboratory at School of Architecture,
Externí odkaz:
https://doaj.org/article/fef07848c93547988cf5259aadfe741d
Autor:
Ji Dong, Yuqiong Hu, Xiaoying Fan, Xinglong Wu, Yunuo Mao, Boqiang Hu, Hongshan Guo, Lu Wen, Fuchou Tang
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-20 (2018)
Abstract Background Organogenesis is crucial for proper organ formation during mammalian embryonic development. However, the similarities and shared features between different organs and the cellular heterogeneity during this process at single-cell r
Externí odkaz:
https://doaj.org/article/4873e4f6e23742199190757e746726f9
Autor:
Daniel A. Haber, Shyamala Maheswaran, Gad Getz, Shannon L. Stott, Mehmet Toner, David T. Ting, Anders M. Näär, Nir Hacohen, Linda T. Nieman, Michelle K. Jewett, Katherine Calhoun, Laxmi Parida, Samuel S. Freeman, Risa Burr, François Aguet, Chenyue Lu, Todd Bonesteel, Dieuwke L. Marvin, Genevieve M. Boland, Elad Horwitz, Benjamin Wesley, Moshe Sade-Feldman, Taronish D. Dubash, Hongshan Guo, Ben S. Wittner, Keith H.K. Wong, Ryan J. Sullivan, Whijae Roh, Xin Hong
Table S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35270a83a7467f2e664efd75752c8ad4
https://doi.org/10.1158/2159-8290.22536592
https://doi.org/10.1158/2159-8290.22536592
Autor:
Daniel A. Haber, Shyamala Maheswaran, Gad Getz, Shannon L. Stott, Mehmet Toner, David T. Ting, Anders M. Näär, Nir Hacohen, Linda T. Nieman, Michelle K. Jewett, Katherine Calhoun, Laxmi Parida, Samuel S. Freeman, Risa Burr, François Aguet, Chenyue Lu, Todd Bonesteel, Dieuwke L. Marvin, Genevieve M. Boland, Elad Horwitz, Benjamin Wesley, Moshe Sade-Feldman, Taronish D. Dubash, Hongshan Guo, Ben S. Wittner, Keith H.K. Wong, Ryan J. Sullivan, Whijae Roh, Xin Hong
Supplementary Information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f8e1b8136568db31ec749753b942ab
https://doi.org/10.1158/2159-8290.22536601.v1
https://doi.org/10.1158/2159-8290.22536601.v1
Autor:
Daniel A. Haber, Hongshan Guo, Ben S. Wittner, Joanna A Vuille, Michael S. Lawrence, Chin-Lee Wu, Mehmet Toner, David T. Miyamoto, Shyamala Maheswaran
Publikováno v:
Cancer Research. 83:IA010-IA010
Cancer-associated alterations in DNA methylation include hypermethylation of focal CpG islands within promoters, as well as hypomethylation of large stretches of gene-poor chromosomal domains, so called Partially Methylated Domains (PMDs). While CpG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8394da3ab1f41fb4962da5c20bede06f
https://doi.org/10.1158/1538-7445.metastasis22-ia010
https://doi.org/10.1158/1538-7445.metastasis22-ia010
Autor:
Li Lan, Hongshan Guo, Tribhuwan Yadav, Haibo Yang, Esther Rheinbay, Jia-Min Zhang, Jian Ouyang, Lee Zou, Daniel A. Haber
Publikováno v:
Nature
Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) in the S and G2 phases of the cell cycle1–3. Several HR proteins are preferentially recruited to DSBs at transcriptionally active loci4–10, but how transcription promotes HR is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f2e025e27ea6f4035a901ca64f87d3
https://doi.org/10.1038/s41586-021-03538-8
https://doi.org/10.1038/s41586-021-03538-8