Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hongran Yin"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 524-535 (2021)
Small interfering RNA (siRNA) for silencing genes and treating disease has been a dream since ranking as a top Breakthrough of the Year in 2002 by Science. With the recent FDA approval of four siRNA-based drugs, the potential of RNA therapeutics to b
Externí odkaz:
https://doaj.org/article/ed5ea473f666481bb5cddb7778c94544
Autor:
Sijin Guo, Mario Vieweger, Kaiming Zhang, Hongran Yin, Hongzhi Wang, Xin Li, Shanshan Li, Shuiying Hu, Alex Sparreboom, B. Mark Evers, Yizhou Dong, Wah Chiu, Peixuan Guo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Although paclitaxel is widely used as a chemotherapy, it suffers from poor solubility and toxicity issues. Here, the authors develop thermostable RNA nanoparticles and report the RNA-paclitaxel complex to display improved stability, drug loading capa
Externí odkaz:
https://doaj.org/article/db868a87fc9b4ea6a3135743c4926948
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Exosomes have shown increasing potential as delivery vesicles for therapy, but challenges like cost/yield, drug payload, and targeting specificity still exist. Plant derived exosome-like nanoparticles have been reported as a promising substi
Externí odkaz:
https://doaj.org/article/cc70cbfff7874052ad1e5e21091fb87a
Publikováno v:
Advanced Science, Vol 6, Iss 22, Pp n/a-n/a (2019)
Abstract Small‐molecule drugs are used extensively in clinics for cancer treatment; however, many antitumor chemical drugs dissolve poorly in aqueous solution. Their poor solubility and nonselective delivery in vivo often cause severe side effects.
Externí odkaz:
https://doaj.org/article/aa71ab1f3a874768a992dad54e8b4b4a
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss, Pp 524-535 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Small interfering RNA (siRNA) for silencing genes and treating disease has been a dream since ranking as a top Breakthrough of the Year in 2002 by Science. With the recent FDA approval of four siRNA-based drugs, the potential of RNA therapeutics to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfb7b4f89ea7138045b7d6f4d38affc
http://www.sciencedirect.com/science/article/pii/S216225312100189X
http://www.sciencedirect.com/science/article/pii/S216225312100189X
Publikováno v:
RNA Nanotechnology and Therapeutics ISBN: 9781003001560
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f4d52c0f071cbcf6f6c121d9c70f33d
https://doi.org/10.1201/9781003001560-48
https://doi.org/10.1201/9781003001560-48
Publikováno v:
RNA Nanotechnology and Therapeutics ISBN: 9781003001560
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7da3e14239f4f357cea92b3536632016
https://doi.org/10.1201/9781003001560-55
https://doi.org/10.1201/9781003001560-55
Publikováno v:
Mol Ther
Triple-negative breast cancer (TNBC) is an aggressive disease with a short median time from relapse to death. The increased aggressiveness, drug resistance, disease relapse, and metastasis are associated with the presence of stem cells within tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fef7c8a96b46adb574fcd4a7216b6f
https://doi.org/10.1016/j.ymthe.2019.04.018
https://doi.org/10.1016/j.ymthe.2019.04.018
Autor:
Yizhou Dong, Wah Chiu, B. Mark Evers, Alex Sparreboom, Mario Vieweger, Shuiying Hu, Hongran Yin, Sijin Guo, Kaiming Zhang, Peixuan Guo, Xin Li, Hongzhi Wang, Shanshan Li
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Paclitaxel is widely used in cancer treatments, but poor water-solubility and toxicity raise serious concerns. Here we report an RNA four-way junction nanoparticle with ultra-thermodynamic stability to solubilize and load paclitaxel for targeted canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5e24aa274d01d4b1efc7f59357ce02
https://doi.org/10.1038/s41467-020-14780-5
https://doi.org/10.1038/s41467-020-14780-5
Publikováno v:
Human Gene Therapy. 29:77-86
Liver or other organ accumulation of drugs is one of the major problems that leads to toxicity and side effects in therapy using chemicals or other macromolecules. It has been shown that specially designed RNA nanoparticles can specifically target ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6634120a654350caad0f3f685814f594
https://doi.org/10.1089/hum.2017.054
https://doi.org/10.1089/hum.2017.054