Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hongqiu Guo"'
Autor:
Zachary J. Hauseman, Michelle Fodor, Anxhela Dhembi, Jessica Viscomi, David Egli, Melusine Bleu, Stephanie Katz, Eunyoung Park, Dong Man Jang, Kathryn A. Porter, Fabian Meili, Hongqiu Guo, Grainne Kerr, Sandra Mollé, Camilo Velez-Vega, Kim S. Beyer, Giorgio G. Galli, Saveur-Michel Maira, Travis Stams, Kirk Clark, Michael J. Eck, Luca Tordella, Claudio R. Thoma, Daniel A. King
Publikováno v:
Nature. 609:416-423
RAS–MAPK signalling is fundamental for cell proliferation and is altered in most human cancers1–3. However, our mechanistic understanding of how RAS signals through RAF is still incomplete. Although studies revealed snapshots for autoinhibited an
Autor:
Cindy Li, Xu Zang, Vijay Sethuraman, Xiaoyu Shen, Johanne Blais, Heinz E. Moser, Kyuto Tashiro, Ellie Growcott, Ramadevi Prathapam, Anthony Casarez, Aregahegn Yifru, Charles Vitt, David McKenney, Tsuyoshi Uehara, Patrick J Rudewicz, Fengxia Li, Hongqiu Guo, Adriana K. Jones, Louis E. Metzger, Wanben Gong, Jacob Shaul, Alun Bermingham, Taryn Cariaga, Richard Colvin, Xiaodong Lin, Dita M. Rasper, Mika Lindvall, Dazhi Tang, Vladimir Capka, Steven Whitebread, Sara Lopez, Meiliana Tjandra, Qingming Zhu, Nancy Turner, Robert Lowell Simmons, Charles R. Dean, Alex Fekete, Folkert Reck
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:748-755
Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-negative bacteria to all classes of β-lactam antibiotics, with the except
Publikováno v:
J Vis Exp
N-methyl-D-aspartate (NMDA) receptors (NMDAR) are classified as ionotropic glutamate receptors and have critical roles in learning and memory. NMDAR malfunction, expressed as either over- or under-activity caused by mutations, altered expression, tra
Publikováno v:
Archives of Biochemistry and Biophysics. 456:175-182
Actin polymerization and depolymerization plays a central role in controlling a wide spectrum of cellular processes. There are many actin-binding proteins in eukaryotic cells. Their roles in the remodeling of the actin architecture and whether they w
Autor:
C.-L. Albert Wang, Hongqiu Guo
Publikováno v:
Biochemical and Biophysical Research Communications. 330:1132-1137
Caldesmon (CaD) is an actin-binding protein that is capable of inhibiting the actomyosin ATPase activity in vitro. CaD has a single gene that is alternatively spliced to generate the smooth muscle-specific form, h-CaD, and a shorter isoform, l-CaD, t
Autor:
Martin Klumpp, Shanni Chen, Hongqiu Guo, Steven Whitebread, Anne Mai Wassermann, Eugen Lounkine, Alexander Fekete, Kevin Hughes, Elena Kutlina, Meir Glick, Laszlo Urban
Publikováno v:
ACS chemical biology. 9(7)
Computational target prediction methods using chemical descriptors have been applied exhaustively in drug discovery to elucidate the mechanisms-of-action (MOAs) of small molecules. To predict truly novel and unexpected small molecule-target interacti
Publikováno v:
Journal of Biological Chemistry. 275:10989-10994
The primary myosin-binding site of caldesmon was thought to be in the N-terminal region of the molecule, but the exact nature of the caldesmon-myosin interaction has not been well characterized. A caldesmon fragment that encompasses residues 1-240 (N
Autor:
Yang Hoon Huh, Chih-Lueh Albert Wang, Hongqiu Guo, Renjian Huang, Yana Khalina-Stackpole, Toshio Kitazawa, Jolanta Kordowska, Shingo Semba, Katsuhide Mabuchi
Publikováno v:
Pflugers Archiv : European journal of physiology. 465(2)
Smooth muscle caldesmon (h-CaD) is an actin- and myosin-binding protein that reversibly inhibits the actomyosin ATPase activity in vitro. To test the function of h-CaD in vivo, we eliminated its expression in mice. The h-CaD-null animals appeared nor
Publikováno v:
Biochemistry. 42(9)
Smooth muscle caldesmon (CaD) binds F-actin and inhibits actomyosin ATPase activity. The inhibition is reversed by Ca2+/calmodulin (CaM). CaD is also phosphorylated upon stimulation at sites specific for mitogen-activated protein kinases (MAPKs). Bec