Výsledky vyhledávání - "Hongqiang Qin"

Akademický článek

Robust Glycoproteomics Platform Reveals a Tetra‐Antennary Site‐Specific Glycan Capping with Sialyl‐Lewis Antigen for Early Detection of Gastric Cancer

Autor: Luyao Liu, Lei Liu, Yan Wang, Zheng Fang, Yangyang Bian, Wenyao Zhang, Zhongyu Wang, Xianchun Gao, Changrui Zhao, Miaomiao Tian, Xiaoyan Liu, Hongqiang Qin, Zhimou Guo, Xinmiao Liang, Mingming Dong, Yongzhan Nie, Mingliang Ye

Publikováno v: Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)

Abstract The lack of efficient biomarkers for the early detection of gastric cancer (GC) contributes to its high mortality rate, so it is crucial to discover novel diagnostic targets for GC. Recent studies have implicated the potential of site‐spec

Externí odkaz: https://doaj.org/article/03f9a0edf24e49cca02bd3cd31163037

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Akademický článek

Glyco-Decipher enables glycan database-independent peptide matching and in-depth characterization of site-specific N-glycosylation

Autor: Zheng Fang, Hongqiang Qin, Jiawei Mao, Zhongyu Wang, Na Zhang, Yan Wang, Luyao Liu, Yongzhan Nie, Mingming Dong, Mingliang Ye

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Poor peptide fragmentation and unusual glycan structures limit mass spectrometry-based analysis of intact N-glycopeptides. Here, the authors develop Glyco-Decipher, a glycan-independent peptide search tool, to tackle these issues and improve the cove

Externí odkaz: https://doaj.org/article/76709b1908e24d76a602e97098454e9f

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Akademický článek

Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression

Publikováno v: Molecular Cancer, Vol 21, Iss 1, Pp 1-18 (2022)

Abstract Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously showed that miR-100 and miR-125b, embedded within the third intron

Externí odkaz: https://doaj.org/article/2ff435c04f444160b7d52b6cb613bda6

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Akademický článek

VLDLR disturbs quiescence of breast cancer stem cells in a ligand-independent function

Autor: Mengying Yang, Yajing Zhan, Zhijie Hou, Chunli Wang, Wenjun Fan, Tao Guo, Zhuoshi Li, Lei Fang, Shasha Lv, Sisi Li, Chundong Gu, Mingliang Ye, Hongqiang Qin, Quentin Liu, Xiaonan Cui

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Breast cancer stem cells are responsible for cancer initiation, progression, and drug resistance. However, effective targeting strategies against the cell subpopulation are still limited. Here, we unveil two splice variants of very-low-density lipopr

Externí odkaz: https://doaj.org/article/f55077191e9c4e41aa100bb1988af191

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Akademický článek

A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)

De novo and acquired resistance are major impediments to the efficacy of conventional and targeted cancer therapy. In unselected gastric cancer (GC) patients with advanced disease, trials combining chemotherapy and an anti-EGFR monoclonal antibody ha

Externí odkaz: https://doaj.org/article/2f5ba06840f94bb7b26d990eb534b538

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