Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Hongqi Xin"'
Autor:
Yuxin Zhou, Hrishti Bhatt, Chromewell A. Mojica, Hongqi Xin, Monica A. Pessina, Douglas L. Rosene, Tara L. Moore, Maria Medalla
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-29 (2023)
Abstract Understanding the microglial neuro-immune interactions in the primate brain is vital to developing therapeutics for cortical injury, such as stroke or traumatic brain injury. Our previous work showed that mesenchymal-derived extracellular ve
Externí odkaz:
https://doaj.org/article/878228c3bc5f434d8173159f8eb9a61a
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 5, Pp 939-943 (2021)
Stroke remains the leading cause of long-term disability. Hemiparesis is one of the most common post-stroke motor deficits and is largely attributed to loss or disruption of the motor signals from the affected motor cortex. As the only direct descend
Externí odkaz:
https://doaj.org/article/fd4dde06652e418d91f04af3ee90567b
Autor:
Hongqi Xin Ph.D., Fengjie Wang, Yanfeng Li, Qing-E Lu, Wing Lee Cheung, Yi Zhang, Zheng Gang Zhang, Michael Chopp
Publikováno v:
Cell Transplantation, Vol 26 (2017)
We previously demonstrated that multipotent mesenchymal stromal cells (MSCs) that overexpress microRNA 133b (miR-133b) significantly improve functional recovery in rats subjected to middle cerebral artery occlusion (MCAO) compared with naive MSCs and
Externí odkaz:
https://doaj.org/article/bab6521a0b724c6f9e52660fd63522e3
Autor:
Zhongwu Liu, Yi Li, Li Zhang, Hongqi Xin, Yisheng Cui, Leah R. Hanson, William H. Frey, II, Michael Chopp
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 2, Pp 804-809 (2012)
As a thrombolytic agent, application of recombinant tissue plasminogen activator (tPA) to ischemic stroke is limited by the narrow time window and side effects on brain edema and hemorrhage. This study examined whether tPA, administered by intranasal
Externí odkaz:
https://doaj.org/article/294c14729a6d4ab08bffe58e282f9ba7
Autor:
Hongqi Xin, Yi Li, Li Hong Shen, Xianshuang Liu, Xinli Wang, Jing Zhang, Siamak Pourabdollah-Nejad D, Chunling Zhang, Li Zhang, Hao Jiang, Zheng Gang Zhang, Michael Chopp
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9027 (2010)
We demonstrate that tissue plasminogen activator (tPA) and its inhibitors contribute to neurite outgrowth in the central nervous system (CNS) after treatment of stroke with multipotent mesenchymal stromal cells (MSCs). In vivo, administration of MSCs
Externí odkaz:
https://doaj.org/article/3db83fdca0764c9fa887ac7cf0df3b66
Autor:
Yuxin Zhou, Hrishti Bhatt, Chromewell A. Mojica, Hongqi Xin, Monica Pessina, Douglas L. Rosene, Tara L. Moore, Maria Medalla
Understanding the microglial neuro-immune interactions in the primate brain is vital to developing therapeutics for cortical injury, such as stroke. Our previous work showed that mesenchymal-derived extracellular vesicles (MSC-EVs) enhanced motor rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a588b7026e48c85673a709eca0882bd
https://doi.org/10.21203/rs.3.rs-2917340/v1
https://doi.org/10.21203/rs.3.rs-2917340/v1
Autor:
Zhongwu Liu, Yi Zhang, hongqi xin, Yanfeng Li, William Golembieski, Mei Lu, Andrew C Dudley, Michael Chopp, Zheng Gang Zhang
Publikováno v:
Stroke. 54
As an integral part of the neuron-glia system, astrocytes directly contact and communicate to neurons. Small extracellular vesicles (sEVs) are essential mediators of intercellular communication for both physiological and pathological processes. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59ce4f726fd2499953f6ddf2e5174f1e
https://doi.org/10.1161/str.54.suppl_1.36
https://doi.org/10.1161/str.54.suppl_1.36
Autor:
Hongqi XIN, Zhongwu Liu, William Golembieski, Yi Zhang, Xianshuang Liu, Zheng Gang Zhang, Michael Chopp
Publikováno v:
Stroke. 54
Introduction: In vivo neuronal mitochondria dysfunction post stroke has not been well investigated. Methods: Using Mito-tag mice in combine with local infection of AAV9 produced from plasmids carrying Cre-recombinase controlled by neuronal promoters,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b36e79edc3fb4d3139723f379ba4b3
https://doi.org/10.1161/str.54.suppl_1.tmp109
https://doi.org/10.1161/str.54.suppl_1.tmp109
Autor:
Jinghuan Fang, Michael Chopp, Li He, Li Zhang, Zheng Gang Zhang, Zhongwu Liu, William A. Golembieski, Fengjie Wang, Hongqi Xin
Publikováno v:
J Cereb Blood Flow Metab
Plasminogen is involved in the process of angiogenesis; however, the underlying mechanism is unclear. Here, we investigated the potential contribution of plasmin/plasminogen in mediating angiogenesis and thereby contributing to functional recovery po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28520c8e8833aeebe3aff5f0546f85cf
https://doi.org/10.1177/0271678x211007958
https://doi.org/10.1177/0271678x211007958
Autor:
Li He, Zhongwu Liu, Xinling Gan, Hongqi Xin, Fengjie Wang, William A. Golembieski, Mei Lu, Michael Chopp
Publikováno v:
J Cereb Blood Flow Metab
Our previous studies demonstrated that axonal remodeling of the corticospinal tract (CST) contributes to neurological recovery after stroke in rodents. The present study employed a novel non-invasive peripheral approach, to over-express tPA in denerv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9c7cfa19b13ecb0cc418f6aae54e4c
https://doi.org/10.1177/0271678x20901686
https://doi.org/10.1177/0271678x20901686