Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Hongqi, Xue"'
Autor:
Shichang Miao, Peter Staehr, Ezra Tai, Borje Darpo, Hongqi Xue, Danielle Armas, Kenneth Webster, Rajneet K. Oberoi
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 7, Pp n/a-n/a (2024)
Abstract This phase I thorough QTc, double‐blind, randomized, placebo‐ and positive‐controlled, parallel group, multiple‐dose study evaluated avacopan's effect on cardiac repolarization using concentration‐QTc (C‐QTc) as the primary analy
Externí odkaz:
https://doaj.org/article/a9cf4106b51344e988533b466eaadf9d
Autor:
Hironobu Tsukada, Snezana M. Milanovic, Borje Darpo, Hongqi Xue, Kuangnan Xiong, Emily Tripp, Lisa Lennek, MaryAlice Worden, Seth C. Hopkins, Gerald R. Galluppi
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 6, Pp 1063-1074 (2023)
Abstract This study (NCT04369391) evaluated the effects of ulotaront (SEP‐363856), a novel trace amine‐associated receptor 1 (TAAR1) agonist in development for schizophrenia, on electrocardiogram parameters. Study design was a randomized, single
Externí odkaz:
https://doaj.org/article/fb931202cdb44672bb881bd23a3cb680
Autor:
Sibel Ucpinar, Borje Darpo, Ann Neale, Philip Nunn, Jin Shu, Katherine A. Chu, Marianne Kavanagh, Hongqi Xue, Pasit Phiasivongsa, Dolca Thomas, Patrick F. Smith
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 6, Pp 1507-1518 (2022)
Abstract This study aimed to define the clinically relevant supratherapeutic dose of rilzabrutinib, an oral Bruton tyrosine kinase (BTK) inhibitor, and evaluate potential effects of therapeutic and supratherapeutic exposures on cardiac repolarization
Externí odkaz:
https://doaj.org/article/3418278264b64f71bc273037eb1ad05f
Autor:
Markus S. Mueller, Patricia N. Sidharta, Christine Voors-Pette, Borje Darpo, Hongqi Xue, Jasper Dingemanse
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-15 (2020)
Abstract Background Fabry disease is a rare inherited glycosphingolipid storage disorder caused by deleterious mutations in the GLA gene coding for the lysosomal enzyme α-galactosidase A. The glucosylceramide synthase inhibitor lucerastat is an imin
Externí odkaz:
https://doaj.org/article/f0abba24de554ee6a78152eb628f9a5e
Autor:
Song Mu, Borje Darpo, Zhiyu Tang, William Novotny, Manal Tawashi, Hongqi Xue, Michael Willett, Leo Lin, Sri Sahasranaman, Ying C. Ou
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 5, Pp 923-931 (2020)
This thorough QT (TQT) study evaluated the effect of zanubrutinib on electrocardiogram (ECG) parameters by using concentration‐QTc (C‐QTc) analysis as the primary analysis for this study. Part A of the study determined the safety and tolerability
Externí odkaz:
https://doaj.org/article/e0ea160c88114e70927aa41ba7867992
Autor:
Borje Darpo, Marie Borin, Georg Ferber, Gerald R. Galluppi, Seth C. Hopkins, Ishani Landry, Arthur Lo, Bhaskar Rege, Larisa Reyderman, Lei Sun, Takao Watanabe, Hongqi Xue, Sally Yasuda
Publikováno v:
The Journal of Clinical Pharmacology. 62:1480-1500
The International Conference on Harmonization (ICH) E14 document was revised in 2015 to allow concentration-corrected QT interval (C-QTc) analysis to be applied to data from early clinical pharmacology studies to exclude a small drug-induced effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b936eea26624b96828e2acb2465bb0
https://doi.org/10.1002/jcph.2095
https://doi.org/10.1002/jcph.2095
Publikováno v:
Clinical Pharmacology in Drug Development. 11:523-534
Cenobamate is an antiseizure medication for uncontrolled focal seizures. This thorough QT study assessed the effects of therapeutic and supratherapeutic cenobamate doses (maximum recommended dose, 400 mg/day) on correct QT interval (QTc) in healthy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85a8f32a2fc10322e2ab4ff83d49718
https://doi.org/10.1002/cpdd.1077
https://doi.org/10.1002/cpdd.1077
Autor:
Frank Schneider, Borje Darpo, Pippa S. Loupe, Hongqi Xue, Helena Knebel, Maria Gutierrez, Mark Forrest Gordon, Laura Rabinovich‐Guilatt
Publikováno v:
Clinical pharmacology in drug developmentReferences. 12(1)
Deutetrabenazine (Austedo) is indicated in adults for chorea associated with Huntington disease and tardive dyskinesia. Escalating deutetrabenazine doses were administered to healthy volunteers who were cytochrome P450 2D6 extensive/intermediate meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f588eb2485a61605abeb0cfd558235
https://pubmed.ncbi.nlm.nih.gov/36098670
https://pubmed.ncbi.nlm.nih.gov/36098670
Autor:
Chunlin Chen, Hongqi Xue, Dan Combs, Roger Lewis Whiting, Borje Darpo, Margaret S. Fletcher, Randall Stoltz
Publikováno v:
Clinical Pharmacology in Drug Development. 10:927-939
Gastroparesis is a chronic neuromuscular disorder of the upper gastrointestinal tract in which episodic exacerbation can lead to frequent hospitalizations and severe disability. Dopamine D2 /D3 receptor antagonists have been used to treat patients wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0216d84dcde90b983edb00f570e90522
https://doi.org/10.1002/cpdd.906
https://doi.org/10.1002/cpdd.906
Autor:
Ishani S. Landry, Peter Boyd, Jagadeesh Aluri, Borje Darpo, Hongqi Xue, Randy Brown, Larisa Reyderman, Robert Lai
Publikováno v:
Alzheimer disease and associated disorders. 36(3)
E2027 is a novel, highly selective and potent inhibitor of phosphodiesterase 9 in development for dementia with Lewy bodies. Cardiac safety assessments for emerging agents are essential to avoid drug-induced QT interval prolongation, which may predis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5905abec78ae03d7dfa4aa23ec19f848
https://pubmed.ncbi.nlm.nih.gov/35622456
https://pubmed.ncbi.nlm.nih.gov/35622456