Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Hongning Fu"'
1
Reform of Practical Teaching of Preventive Medicine Undergraduates
Autor: Hongning Fu
Publikováno v: Preventive Medicine Research. 9:23
Professional practice, as an important link of comprehensive talent training for preventive medicine students, is of great significance to cultivate innovative and practical talents. However, there are some problems in the current teaching system, su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2d4b576c225b09492a8efcab24968a6
https://doi.org/10.18282/pmr.v9i1.1380
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2
Synthesis of 2,4-Diamino-6-[2‘-O-(ω-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as Potent and Selective Inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium Dihydrofolate Reductase
Autor: Sherry F. Queener, Andre Rosowsky, Hongning Fu, David Chan
Publikováno v: Journal of Medicinal Chemistry. 47:2475-2485
Six previously undescribed N-(2,4-diaminopteridin-6-yl)methyldibenz[b,f]azepines with water-solubilizing O-carboxyalkyloxy or O-carboxybenzyloxy side chains at the 2'-position were synthesized and compared with trimethoprim (TMP) and piritrexim (PTX)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1311a87565d8fd0805dbb4f4ef3e344a
https://doi.org/10.1021/jm030599o
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3
Synthesis of new 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidines via the Taylor ring transformation/ring annulation strategy
Autor: Sherry F. Queener, Andre Rosowsky, Hongning Fu
Publikováno v: Journal of Heterocyclic Chemistry. 38:1197-1202
Selected examples 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidines with a phenyl or benzyl group at the 5-position were synthesized as inhibitors of dihydrofolate reductase (DHFR) from Pneumocystis carinii and Toxoplasma gondii, two potentially life-threaten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65fdbb2297499bc3394d437e0579a846
https://doi.org/10.1002/jhet.5570380526
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4
Synthesis of 2,4-diaminopyrido[2,3-d]pyrimidines and 2,4-diamino-quinazolines with bulky dibenz[b,f]azepine and dibenzo[a,d]-cycloheptene substituents at the 6-position as inhibitors of dihydrofolate reductases frompneumocystis carinii, toxoplasma gondii, andmycobacterium avium
Autor: Hongning Fu, Andre Rosowsky, Sherry F. Queener
Publikováno v: Journal of Heterocyclic Chemistry. 37:921-926
The synthesis of four previously undescribed 2,4-diaminopyrido[2,3-d]pyrimidines (3,4) and 2,4-diaminoquinazolines (5,6) with a bulky tricyclic aromatic group at the 6-position is described. Condensation of dibenz[b,f]azepine with 2,4-diamino-6-bromo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82f68877276887f793d4b71ccbaa31dd
https://doi.org/10.1002/jhet.5570370440
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5
Structure-Based Design of Selective Inhibitors of Dihydrofolate Reductase: Synthesis and Antiparasitic Activity of 2,4-Diaminopteridine Analogues with a Bridged Diarylamine Side Chain
Autor: Andre Rosowsky, and Andrew T. Papoulis, Nikolai Galitsky, Hongning Fu, Sherry F. Queener, Vivian Cody
Publikováno v: Journal of Medicinal Chemistry. 42:4853-4860
As part of a larger search for potent as well as selective inhibitors of dihydrofolate reductase (DHFR) enzymes from opportunistic pathogens found in patients with AIDS and other immune disorders, N-[(2,4-diaminopteridin-6-yl)methyl]dibenz[b,f]azepin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5968967e2c5c379b6d21713a9e7926e
https://doi.org/10.1021/jm990331q
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6
Intramolecular Electron Transfer across Amino Acid Spacers in the Picosecond Time Regime. Charge-Transfer Interaction through Peptide Bonds
Autor: Guilford Jones, Churl Oh, Scott R. Greenfield, Michael R. Wasielewski, David Gosztola, Hongning Fu, Lily N. Lu, Catie Weiss Farahat
Publikováno v: The Journal of Physical Chemistry B. 103:572-581
For a series of alanine-based peptides having 1−3 amino acid residues as spacers, the chromophore, pyrenesulfonyl (Pyr), has been attached at the N-terminus and an electron donor, dimethyl-1,4-benzenediamine (DMPD), covalently bound at the C-termin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fb3de40921734845a8e0f8d10c89200
https://doi.org/10.1021/jp9832802
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7
Synthesis and in Vitro Activity of Long-Chain 5‘-O-[(Alkoxycarbonyl)phosphinyl]-3‘-azido-3‘-deoxythymidines against Wild-Type and AZT- and Foscarnet-Resistant Strains of HIV-1
Autor: Niranjan Pai, John Mellors, Douglas D. Richman, Andre Rosowsky, Karl Y. Hostetler, Hongning Fu
Publikováno v: Journal of Medicinal Chemistry. 40:2482-2490
Lipophilic esters of 3'-azido-3'-deoxy-5'-O-(carboxyphosphinyl)thymidine (PFA-AZT) were synthesized and tested for antiretroviral activity in CD4+ HT4-6C cells infected with either wild-type HIV-1LAI, a PFA-resistant strain encoding a single-point mu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882f4d9abe6b54b1b8d57a682d31ca74
https://doi.org/10.1021/jm970172f
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8
ChemInform Abstract: Synthesis of New 2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidines via the Taylor Ring Transformation/Ring Annulation Strategy
Autor: Sherry F. Queener, Andre Rosowsky, Hongning Fu
Publikováno v: ChemInform. 33
Selected examples 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidines with a phenyl or benzyl group at the 5-position were synthesized as inhibitors of dihydrofolate reductase (DHFR) from Pneumocystis carinii and Toxoplasma gondii, two potentially life-threaten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::918516c8adee1c77980fd723d3da6585
https://doi.org/10.1002/chin.200207152
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9
Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain
Autor: Andre Rosowsky, Ronald A. Forsch, David Chan, Hongning Fu, Sherry F. Queener
Publikováno v: Journal of medicinal chemistry. 48(13)
As part of a search for dihydrofolate reductase (DHFR) inhibitors combining the high potency of piritrexim (PTX) with the high antiparasitic vs mammalian selectivity of trimethoprim (TMP), the heretofore undescribed 2,4-diamino-6-(2',5'-disubstituted
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b93e2fd2811b91891c4bda07b6a499
https://pubmed.ncbi.nlm.nih.gov/15974594
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10
Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase
Autor: Andre, Rosowsky, Hongning, Fu, David C M, Chan, Sherry F, Queener
Publikováno v: Journal of medicinal chemistry. 47(10)
Six previously undescribed N-(2,4-diaminopteridin-6-yl)methyldibenz[b,f]azepines with water-solubilizing O-carboxyalkyloxy or O-carboxybenzyloxy side chains at the 2'-position were synthesized and compared with trimethoprim (TMP) and piritrexim (PTX)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15590369c8cc71c78268a1035742c52a
https://pubmed.ncbi.nlm.nih.gov/15115391
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