Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hongnga T. Le"'
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Graft-versus-host disease (GvHD) remains a significant complication of allogeneic hematopoietic cell transplantation (HCT), associated with significant morbidity and mortality. GvHD is characterized by dysregulated immune responses and resulting tiss
Externí odkaz:
https://doaj.org/article/e3823b0f7900478fb3e0bfbb167c0d64
Autor:
Sivakumar Periasamy, Kristen A. Porter, Maninjay K. Atianand, Hongnga T. Le, Sarah Earley, Ellen B. Duffy, Matthew C. Haller, Heather Chin, Jonathan A. Harton
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Pyrin-only proteins (POPs) are primate-specific negative regulators of inflammasome activation. Here the authors generate transgenic mice expressing POP2 under the control of the human promoter, and show that POP2 is important for balancing antibacte
Externí odkaz:
https://doaj.org/article/0563f30dbd054df89affef0a6ff7f607
Autor:
Hongnga T. Le, Jonathan A. Harton
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Upon activation Nod-like receptors (NLRs) assemble into multi-protein complexes such as the NODosome and inflammasome. This process relies upon homo-domain interactions between the structurally related Pyrin and caspase-recruitment (CARD) domains and
Externí odkaz:
https://doaj.org/article/f668f6f1797f4016ab964aec7cee6988
Autor:
Si-Nan Lin, Alessandro Musso, Jie Wang, Pranab K. Mukherjee, Gail A. West, Ren Mao, Ruishen Lyu, Jiannan Li, Shuai Zhao, Michael Elias, Yael Haberman, Lee A. Denson, Subra Kugathasan, Min-Hu Chen, Doug Czarnecki, Dina Dejanovic, Hongnga T. Le, Jyotsna Chandra, Jeremy Lipman, Scott R. Steele, Quang Tam Nguyen, Claudio Fiocchi, Florian Rieder
Publikováno v:
Matrix Biol
OBJECTIVE: Inflammatory bowel diseases (IBD) cause chronic intestinal damage and extracellular matrix (ECM) remodeling. The ECM may play an active role in inflammation by modulating immune cell functions, including cell adhesion, but this hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e90ed861d396371c1796313dba2da7d
https://europepmc.org/articles/PMC10043923/
https://europepmc.org/articles/PMC10043923/
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006059 (2016)
Francisella tularensis (Ft) causes a frequently fatal, acute necrotic pneumonia in humans and animals. Following lethal Ft infection in mice, infiltration of the lungs by predominantly immature myeloid cells and subsequent myeloid cell death drive pa
Externí odkaz:
https://doaj.org/article/7d4cc131edf44f8eb05e164857f96d86
Publikováno v:
The American Journal of Pathology. 191:40-51
Chronic inflammatory diseases cause profound alterations in tissue homeostasis, including unchecked activation of immune and nonimmune cells leading to disease complications such as aberrant tissue repair and fibrosis. Current anti-inflammatory thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::744cceaf2f7d5a91fa59b1e8e3b6adc9
https://doi.org/10.1016/j.ajpath.2020.09.007
https://doi.org/10.1016/j.ajpath.2020.09.007
Autor:
Hongnga T. Le, Booki Min, Quang Tam Nguyen, Dongkyun Kim, Serpil C. Erzurum, Jaehyuk Choi, Terry D. Hinds, Sohee Kim, Kewal Asosingh, Peter Bazeley, Supinya Iamsawat, John J. O'Shea, Kevin T Qiu
Publikováno v:
J Immunol
Glucocorticoids are a highly effective first-line treatment option for many inflammatory diseases, including asthma. Some patients develop a steroid-resistant condition, yet, the cellular and molecular mechanisms underlying steroid resistance remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c4f35f051ea82135fdfe0494e3d50b
https://europepmc.org/articles/PMC8323959/
https://europepmc.org/articles/PMC8323959/
Publikováno v:
The Journal of Immunology. 202:1680-1685
IL-27 regulates immune responses in inflammation. The underlying mechanism of IL-27 functions has long been attributed to its ability to induce IL-10 production in activated CD4 T cells. In this study, we report that Foxp3+ regulatory T cells (Tregs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc3b80419a72238c99b5aaa21ca6db1
https://doi.org/10.4049/jimmunol.1800898
https://doi.org/10.4049/jimmunol.1800898
Autor:
Markus F. Neurath, Hongnga T. Le, Claudio Fiocchi, Florian Rieder, Jie Wang, Shuai Zhao, Michael Elias, Clemens Neufert
Publikováno v:
J Clin Invest
IL-36 is a member of the IL-1 superfamily and consists of three agonists and one receptor antagonist (IL-36Ra). The three endogenous agonists, IL-36α, -β, and -γ, act primarily as proinflammatory cytokines, and their signaling through the IL-36 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6207e8ecdbda0b69bbd3815b0cc5b2
https://pubmed.ncbi.nlm.nih.gov/33463541
https://pubmed.ncbi.nlm.nih.gov/33463541
Publikováno v:
Am J Pathol
Chronic inflammatory diseases cause profound alterations in tissue homeostasis, including unchecked activation of immune and nonimmune cells leading to disease complications such as aberrant tissue repair and fibrosis. Current anti-inflammatory thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f41adcaa9105be9b71063bdf6c4f92c7
https://pubmed.ncbi.nlm.nih.gov/33039354
https://pubmed.ncbi.nlm.nih.gov/33039354