Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Hongjuan He"'
Autor:
Lan Shao, Haoran Yu, Mengyun Wang, Lu Chen, Boshu Ji, Tong Wu, Xiangqi Teng, Mu Su, Xiao Han, Weikai Shi, Xin Hu, Ziwen Wang, Hongjuan He, Guiping Han, Yan Zhang, Qiong Wu
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-20 (2024)
Abstract Super-enhancers are a class of DNA cis-regulatory elements that can regulate cell identity, cell fate, stem cell pluripotency, and even tumorigenesis. Increasing evidence shows that epigenetic modifications play an important role in the path
Externí odkaz:
https://doaj.org/article/a2ae6e85b9bb40549537f4e9a90992ed
Autor:
Ximeijia Zhang, Hongjuan He, Haoran Yu, Xiangqi Teng, Ziwen Wang, Chenghao Li, Jiahang Li, Haopeng Yang, Jiwei Shen, Tong Wu, Fengwei Zhang, Yan Zhang, Qiong Wu
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract The placenta is a unique organ for ensuring normal embryonic growth in the uterine. Here, we found that maternal RNA transcription in Dlk1-Dio3 imprinted domain is essential for placentation. PolyA signals were inserted into Gtl2 to establis
Externí odkaz:
https://doaj.org/article/33777bf4dc3b4944a65a73b2a8a338ea
Autor:
Xiangqi Teng, Hongjuan He, Haoran Yu, Ximeijia Zhang, Jie Xing, Jiwei Shen, Chenghao Li, Mengyun Wang, Lan Shao, Ziwen Wang, Haopeng Yang, Yan Zhang, Qiong Wu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8184 (2024)
The Dlk1-Dio3 domain is important for normal embryonic growth and development. The heart is the earliest developing and functioning organ of the embryo. In this study, we constructed a transcriptional termination model by inserting termination sequen
Externí odkaz:
https://doaj.org/article/cd38ecbbb2d54a03897e22b6c2764e5d
Autor:
Xin Liu, Hongjuan He, Fengwei Zhang, Xin Hu, Fanqi Bi, Kai Li, Haoran Yu, Yue Zhao, Xiangqi Teng, Jiaqi Li, Lihong Wang, Yan Zhang, Qiong Wu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-12 (2022)
Abstract Exploring the epigenetic regulation mechanism of colorectal cancer (CRC) from the perspective of N6-methyladenosine (m6A) modification may provide a new target for tumor therapy. Analysis using high-throughput RNA-seq profile from TCGA found
Externí odkaz:
https://doaj.org/article/22d351c34ee0479f8b2d9c8072de5652
Publikováno v:
Canadian Respiratory Journal, Vol 2023 (2023)
Objective. Dysregulation of epithelial-mesenchymal transition (EMT) in the airway epithelium is associated with airway remodeling and the progression of pulmonary fibrosis. Many treatments have been shown to inhibit airway remodeling and pulmonary fi
Externí odkaz:
https://doaj.org/article/7411e5a436904358ace58b394a7278a5
Publikováno v:
Genes, Vol 14, Iss 6, p 1264 (2023)
Meg8-DMR is the first maternal methylated DMR to be discovered in the imprinted Dlk1-Dio3 domain. The deletion of Meg8-DMR enhances the migration and invasion of MLTC-1 depending on the CTCF binding sites. However, the biological function of Meg8-DMR
Externí odkaz:
https://doaj.org/article/f0f51e15a64d4c4ab9b90fca69a94f75
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-14 (2021)
Abstract Super-enhancers or stretch enhancers (SEs) consist of large clusters of active transcription enhancers which promote the expression of critical genes that define cell identity during development and disease. However, the role of many super-e
Externí odkaz:
https://doaj.org/article/d6251d055b8149bebbcaf7bcba83e18b
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Airway remodeling is associated with dysregulation of epithelial-mesenchymal transition (EMT) in patients with asthma. Sinomenine (Sin) is an effective, biologically active alkaloid that has been reported to suppress airway remodeling in mice with as
Externí odkaz:
https://doaj.org/article/19734fcc5b0d4066865ff70cdc7e9b5a
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8828 (2022)
The Dlk1-Dio3 imprinted domain on mouse chromosome 12 contains three well-characterized paternally methylated differentially methylated regions (DMRs): IG-DMR, Gtl2-DMR, and Dlk1-DMR. These DMRs control the expression of many genes involved in embryo
Externí odkaz:
https://doaj.org/article/796cccdcab0b4baf968cfe1de5bdf06a
Autor:
Erfei Chen, Fangfang Yang, Hongjuan He, Qiqi Li, Wei Zhang, Jinliang Xing, Ziqing Zhu, Jingjing Jiang, Hua Wang, Xiaojuan Zhao, Ruitao Liu, Lei Lei, Jing Dong, Yuchen Pei, Ying Yang, Junqiang Pan, Pan Zhang, Shuzhen Liu, Le Du, Yuan Zeng, Jin Yang
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-13 (2018)
Abstract Background Although the genetic spectrum of human colorectal cancer (CRC) is mainly characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not been conclusively demonstrated. In this study, we aimed to identify
Externí odkaz:
https://doaj.org/article/dcc4a19a25b84b14b660957ed1b4a0ae