Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hongjin Zhai"'
Autor:
Firas Obaid Arhema Frejat, Yaquan Cao, Hongjin Zhai, Salah A. Abdel-Aziz, Hesham A.M. Gomaa, Bahaa G.M. Youssif, Chunli Wu
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 1, Pp 103538- (2022)
DNA gyrase is a promising target for antibacterial agents. Several classes of small-molecule inhibitors have been discovered in recent decades, but none of these have reached the market. We have designed a small library of 1,2,4-oxadiazole/pyrrolidin
Externí odkaz:
https://doaj.org/article/120d5a647ab344a98570653092417f49
Autor:
null Hongjin Zhai, Shuo Zhang, Maxwell Ampomah-Wireko, Huanhuan Wang, Yaquan Cao, Pu Yang, Yingxue Yang, Firas Obald Arhema Frejat, Lihong Wang, Bingbing Zhao, Changzhong Ren, Chunli Wu
Publikováno v:
Russian Journal of Bioorganic Chemistry. 48:1175-1189
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7462199408293866c291f1c56fcd659
https://doi.org/10.1134/s1068162022060280
https://doi.org/10.1134/s1068162022060280
Autor:
null Hongjin Zhai, Ziwei Lin, Zhengmin Fan, Huanhuan Wang, Firas Obald Arhema Frejat, Yingxue Yang, Yaquan Cao, Chunli Wu
Publikováno v:
Russian Journal of Bioorganic Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d3e2747233bb312021ece9ff5588004
https://doi.org/10.1134/s1068162023030287
https://doi.org/10.1134/s1068162023030287
Autor:
Hongjin Zhai, Lin, Ziwei, Fan, Zhengmin, Wang, Huanhuan, Frejat, Firas Obald Arhema, Yang, Yingxue, Cao, Yaquan, Wu, Chunli
Publikováno v:
Russian Journal of Bioorganic Chemistry; Jun2023, Vol. 49 Issue 3, p462-468, 7p
Autor:
Firas Obaid Arhema Frejat, Hongjin Zhai, Yaquan Cao, Lihong Wang, Yaser A. Mostafa, Hesham A.M. Gomaa, Bahaa G.M. Youssif, Chunli Wu
Publikováno v:
Bioorganic chemistry. 126
Indazole is a significant class of heterocyclic compounds with a wide range of biological activity. We display here the synthesis and biological evaluation of a novel series of indazole derivatives 6a-v, which are differently substituted at the 6-pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4681470522349358fcd83681139f40c0
https://pubmed.ncbi.nlm.nih.gov/35667253
https://pubmed.ncbi.nlm.nih.gov/35667253
Autor:
Hongjin Zhai, Chunying Luo, Pu Yang, Shuo Zhang, Huanhuan Wang, Yaquan Cao, Yingxue Yang, Haoyue Liu, Xiaoyan Kong, Firas Obald Arhema Frejat, Changzhong Ren, Xiufang Shi, Chunli Wu
Publikováno v:
European journal of medicinal chemistry. 238
With the increasing incidence of antibiotic resistance, there is an urgent need to develop new antibiotics with excellent activity against drug-resistant bacteria. Three novel series of tylosin semisynthetic derivatives were designed, synthesized and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76dbd1bdf8f4cb4343b200c5d2c88d65
https://pubmed.ncbi.nlm.nih.gov/35675753
https://pubmed.ncbi.nlm.nih.gov/35675753
Autor:
Yaquan Cao, Yingxue Yang, Maxwell Ampomah-Wireko, Firas Obaid Arhema Frejat, Hongjin Zhai, Shuo Zhang, Huanhuan Wang, Pu Yang, Qingyan Yuan, Guanlian Wu, Chunli Wu
Publikováno v:
Bioorganicmedicinal chemistry letters. 64
In this study, a novel batch of indazole containing 1,2,3-triazole agents were designed and synthesized. The antiproliferative activity of target compounds in four human cancer cells, PC-3 (human prostate cancer cell), MCF-7 (human breast cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34db25b93e75933da2e335e38d59a628
https://pubmed.ncbi.nlm.nih.gov/35259487
https://pubmed.ncbi.nlm.nih.gov/35259487
Autor:
Yaquan Cao, Firas Obaid Arhema Frejat, Hesham A.M. Gomaa, Hongjin Zhai, Salah A. Abdel-Aziz, Chunli Wu, Bahaa G.M. Youssif
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 1, Pp 103538-(2022)
DNA gyrase is a promising target for antibacterial agents. Several classes of small-molecule inhibitors have been discovered in recent decades, but none of these have reached the market. We have designed a small library of 1,2,4-oxadiazole/pyrrolidin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337191869b94ed849c61492e1325acb0
http://www.sciencedirect.com/science/article/pii/S1878535221005530
http://www.sciencedirect.com/science/article/pii/S1878535221005530
Autor:
Hongjin Zhai, Zhang, Shuo, Ampomah-Wireko, Maxwell, Wang, Huanhuan, Cao, Yaquan, Yang, Pu, Yang, Yingxue, Frejat, Firas Obald Arhema, Wang, Lihong, Zhao, Bingbing, Ren, Changzhong, Wu, Chunli
Publikováno v:
Russian Journal of Bioorganic Chemistry; Dec2022, Vol. 48 Issue 6, p1175-1189, 15p
Autor:
Firas O. A. Frejat, Yaquan Cao, Lihong Wang, Hongjin Zhai, Ahmed H. Abdelazeem, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Chunli Wu
Publikováno v:
Archiv der Pharmazie. 355:2100516
A series of hybridized pyrrolidine compounds with a 1,2,4-oxadiazole moiety were synthesized to develop effective molecules against the enzymes DNA gyrase and topoisomerase IV (Topo IV). Compounds 8-20 were developed based on a previously disclosed s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fcecb9160a475328e8025de95eb093
https://doi.org/10.1002/ardp.202100516
https://doi.org/10.1002/ardp.202100516