Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hongjie Qian"'
Autor:
Yun Liu, Wei Wang, Hongjie Qian, Yuzhou Gui, Yating Wang, Rong Song, Qian Chen, Eric Rowinsky, Sheng Wang, Xiaoguang Liang, Kaicun Gu, Bo Zhou, Weiwei Zhang, Liqin Zhang, Chen Yu, Jingying Jia
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract This study evaluated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and food effects (FE) of SC0062, a highly active endothelin‐A (ETA) receptor antagonist, in healthy subjects. The primary objectives of this first
Externí odkaz:
https://doaj.org/article/f1f117802baf44e7857f348d41657239
Autor:
Hongjie Qian, Jie Cheng, Yuzhou Gui, Wei Wang, Liyu Liang, Huijuan Zhu, Qingqing Wu, Meixian Ou, Qian Chen, Chen Yu, Jingying Jia
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 9, Pp 1704-1712 (2023)
Abstract This study aimed to evaluate the pharmacokinetic (PK) similarity of the proposed biosimilar HS628 compared with the reference tocilizumab (Actemra®) and also to demonstrate similar safety and immunogenicity profiles in healthy Chinese male
Externí odkaz:
https://doaj.org/article/3a81076c66c0476f8ed34e304c4e3c9d
Autor:
Chengyin Yu, Hongjie Qian, Qingqing Wu, Yang Zou, Qicheng Ding, Yuting Cai, Liyu Liang, Juncai Xu, Lei Li, Bin Zan, Yongguo Li, Yun Liu
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract This study aimed to assess the safety, pharmacokinetics, and food impact on sudapyridine (WX‐081), a novel drug designed to inhibit mycobacterium ATP synthase, with clinical applications for drug‐resistant tuberculosis (TB) treatment. Th
Externí odkaz:
https://doaj.org/article/3ef73d703b9444ae8e3596ff07624e4a
Autor:
Hongjie Qian, Chengyin Yu, Huijuan Zhu, Qichen Ding, Yuting Cai, Jiao Jing, Xin Xu, Runcong Guo, Haiyan Zhang, Hong Liu, Xiaoyan Chen, Yun Liu
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 5, Pp 810-822 (2023)
Abstract The present study evaluated the safety, tolerability, and pharmacokinetics of fluoropezil (DC20), a novel acetylcholinesterase inhibitor under development for the treatment of Alzheimer's disease (AD) in otherwise healthy young and elderly C
Externí odkaz:
https://doaj.org/article/904ad7e8b75f461e96a66e46a6a53ed8
Publikováno v:
Shock and Vibration, Vol 2018 (2018)
A safety assessment of a chimney under the action of wind and earthquake is performed on one of the reinforced concrete chimneys in the Jinchuan company in China. The assessment is based on the linear filtering method, and wind loads of several heigh
Externí odkaz:
https://doaj.org/article/1b3ac93a37da41baa3fae2b01b29fac9
Autor:
Xiaojiao Li, Katherine Chai, Yanhua Ding, Min Wu, Jixuan Sun, Xiaodi Zhang, Chen Yu, Hongjie Qian, Xiaoxue Zhu
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose To compare the pharmacokinetic profiles, safety and immunogenicity of proposed bevacizumab biosimilar HLX04 with reference bevacizumab in healthy Chinese males. Methods In this double-blind Phase 1 study, healthy volunteers (N = 208) were ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727d2b14e50e3a02ef655e4aa4b3ac47
https://doi.org/10.1007/s00280-021-04297-z
https://doi.org/10.1007/s00280-021-04297-z
Publikováno v:
Organic & Biomolecular Chemistry. 19:8591-8596
An efficient and highly regioselective Pd-catalyzed direct arene C(sp2)–H acyloxylation of pyrrolo[2,3-d]pyrimidine derivatives is reported. The key strategy involves the utilization of the unique reactivity of pyrrolo[2,3-d]pyrimidine and the empl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::463406d7c0a08a7d9c69d385c1e2b126
https://doi.org/10.1039/d1ob01486b
https://doi.org/10.1039/d1ob01486b
Autor:
Tingting Li, Xue Wu, Yang Sai, Weiguo Su, Chen Yu, Ke Li, Qian Chen, Wei Wang, Jingying Jia, Yan-mei Liu, Hongjie Qian
Publikováno v:
Clinical Therapeutics. 42:1778-1786
Purpose Surufatinib is a potent and orally active small-molecule tyrosine kinase inhibitor targeting VEGFRs 1 to 3, FGFR-1, and CSF-1R, and thus may exert antitumor and antiangiogenic effects. The objective of this study was to determine the tolerabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05c01f0ded9ce152c87861f7bd7c1a6
https://doi.org/10.1016/j.clinthera.2020.07.010
https://doi.org/10.1016/j.clinthera.2020.07.010
Autor:
Zhen Wang, Guanghui Tian, Huijuan Zhu, Qian Chen, Jingying Jia, Hualiang Jiang, Chen Yu, Liyu Liang, Jingshan Shen, Hongjie Qian, Hua-Hua Pu, Rong Song, Tingting Li, Yu Wang, Liang Xin, Yang Zou
Publikováno v:
Drug Design, Development and Therapy
Hongjie Qian,1,2 Qian Chen,1,2 Liyu Liang,1,2 Yang Zou,1,2 Huahua Pu,1,2 Liang Xin,1,2 Rong Song,1,2 Tingting Li,1,2 Huijuan Zhu,1,2 Yu Wang,3 Guanghui Tian,4 Jingshan Shen,2,3 Hualiang Jiang,2,3 Chen Yu,1,2 Zhen Wang,2,3 Jingying Jia1,2 1Central Lab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b4659c9dab58215301c7007b412d35
https://www.dovepress.com/a-phase-i-study-to-evaluate-the-safety-tolerability-and-pharmacokineti-peer-reviewed-fulltext-article-DDDT
https://www.dovepress.com/a-phase-i-study-to-evaluate-the-safety-tolerability-and-pharmacokineti-peer-reviewed-fulltext-article-DDDT
Autor:
Yuzhou Gui, Meng-qi Zhang, Jingying Jia, Gangyi Liu, Jingshan Shen, Hongjie Qian, Jiajin He, Haiming Liu, Chen Yu, Zhen Wang
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 191
A simple, rapid and accurate method for quantitative analysis of a highly selective phosphodiesterase-5 inhibitor (PDE5), TPN171 by high performance liquid chromatography and tandem mass spectrometry in human plasma was proposed and validated success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f2c0cc432f3b405556575b1cc0c6f9
https://pubmed.ncbi.nlm.nih.gov/32987249
https://pubmed.ncbi.nlm.nih.gov/32987249