Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Honghe Zhang"'
Autor:
Yi Liu, Jiani Yi, Pin Wu, Jun Zhang, Xufan Li, Jia Li, Liyuan Zhou, Yong Liu, Haiming Xu, Enguo Chen, Honghe Zhang, Mingyu Liang, Pengyuan Liu, Xiaoqing Pan, Yan Lu
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract DNA methylation, an epigenetic mechanism that alters gene expression without changing DNA sequence, is essential for organism development and key biological processes like genomic imprinting and X‐chromosome inactivation. Despite tremendou
Externí odkaz:
https://doaj.org/article/d75fac1648ec411a83594c7fb7ac1b3b
Autor:
Jingwen Deng, Shaoxia Liao, Chaoyi Chen, Fengyan Han, Siqin Lei, Xuan Lai, Kehong Ye, Qizheng Han, Fang E, Chao Lu, Maode Lai, Fanlong Liu, Honghe Zhang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-15 (2023)
Abstract Our previous study demonstrated that tumor-suppressor circular RNAs (circRNAs) can be specifically secreted outside of colorectal cancer (CRC) cells within exosomes to maintain tumor cell fitness. However, whether tumor-driving circRNAs can
Externí odkaz:
https://doaj.org/article/ce8f82a4d54b471db7f191f54ec1347e
Autor:
Jing Sun, Jianhui Zhao, Fangyuan Jiang, Lijuan Wang, Qian Xiao, Fengyan Han, Jie Chen, Shuai Yuan, Jingsun Wei, Susanna C. Larsson, Honghe Zhang, Malcolm G Dunlop, Susan M Farrington, Kefeng Ding, Evropi Theodoratou, Xue Li
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) study to identify candidate protein markers and therapeutic targets for colorectal cancer (CRC). Methods Protein quan
Externí odkaz:
https://doaj.org/article/c3278b2d6c4c4125ad2171ac1ae5e07a
Autor:
Mengqian Yu, Jiani Yi, Qiongzi Qiu, Dongxia Yao, Jia Li, Juze Yang, Chunyi Mi, Liyuan Zhou, Bingjian Lu, Weiguo Lu, Kejing Ying, Wantao Chen, Enguo Chen, Honghe Zhang, Zhimin Lu, Yan Lu, Pengyuan Liu
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113408- (2023)
Summary: Transfer RNA-derived fragments (tRFs) are a class of small non-coding regulatory RNAs that are involved in the pathophysiology of many diseases. However, the role of tRFs in cancer progression remains largely elusive. Here, we demonstrate th
Externí odkaz:
https://doaj.org/article/de633d8206fb4455896bcd63cd57e29c
Autor:
Siqin Lei, Chaoyi Chen, Fengyan Han, Jingwen Deng, Dongdong Huang, Lili Qian, Ming Zhu, Xiaohui Ma, Maode Lai, Enping Xu, Honghe Zhang
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113110- (2023)
Summary: The crosstalk between ferroptosis and cancer metastasis remains unclear. Here, we identify AMER1 as a key regulator of ferroptosis. AMER1 loss causes resistance to ferroptosis in colorectal cancer (CRC) cells. Interestingly, AMER1-deficient
Externí odkaz:
https://doaj.org/article/efe51dd862804c759f06b382eb3958ce
Autor:
Aoran Luo, Xiaoxiao Lan, Qiongzi Qiu, Qing Zhou, Jia Li, Mengting Wu, Pengyuan Liu, Honghe Zhang, Bingjian Lu, Yan Lu, Weiguo Lu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-13 (2022)
Abstract Long non-coding RNAs (lncRNAs) play key roles in cancer development and progression. However, the biological function and clinical significance of most lncRNAs in cervical cancer remain elusive. In this study, we explore the function and mec
Externí odkaz:
https://doaj.org/article/e53563d6ab36437faed2c1b0a15e81c0
Autor:
Juze Yang, Xinyi Qian, Qiongzi Qiu, Lingling Xu, Meidie Pan, Jia Li, Jiayi Ren, Bingjian Lu, Ting Qiu, Enguo Chen, Kejing Ying, Honghe Zhang, Yan Lu, Pengyuan Liu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-13 (2022)
Abstract Long non-coding RNAs (lncRNAs) is known to play vital roles in modulating tumorigenesis. We previously reported that LCAT1, a novel lncRNA, promotes the growth and metastasis of lung cancer cells both in vitro and in vivo. However, the under
Externí odkaz:
https://doaj.org/article/5b37e644aa974f94b3299a9c73138aa1
Autor:
Mengting Wu, Qiongzi Qiu, Qing Zhou, Jia Li, Juze Yang, Chengcai Zheng, Aoran Luo, Xufan Li, Honghe Zhang, Xiaodong Cheng, Weiguo Lu, Pengyuan Liu, Bingjian Lu, Yan Lu
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-19 (2022)
Abstract Background CircRNAs are a novel class of evolutionarily conserved noncoding RNA molecules that form covalently closed continuous loop structures without 5′ caps and 3′ poly(A) tails. Accumulating evidence suggests that circRNAs play impo
Externí odkaz:
https://doaj.org/article/c4cf1b04f1dd4ff28627db07b46177af
Autor:
Chaoyi Chen, Hongfei Yu, Fengyan Han, Xuan Lai, Kehong Ye, Siqin Lei, Minglang Mai, Maode Lai, Honghe Zhang
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-19 (2022)
Abstract Background & Aims To clarify the biological roles, circularization process and secretion pathway of circRHOBTB3 in colorectal cancer (CRC) progression. Methods We performed a comprehensive analysis of circRNA levels in serum exosomes from mu
Externí odkaz:
https://doaj.org/article/13d98dd752264a3cb3f6103d22446079
Publikováno v:
Genes, Vol 13, Iss 9, p 1659 (2022)
Substantial emerging evidence supports that dysregulated RNA metabolism is associated with tumor initiation and development. Serine/Arginine-Rich proteins (SR) are a number of ultraconserved and structurally related proteins that contain a characteri
Externí odkaz:
https://doaj.org/article/82c9d5b5b9244f7bab4b97bff1e80817