Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Hongfen Guo"'
Autor:
Alan W Long, Hong Xu, Brian H Santich, Hongfen Guo, Sayed Shahabuddin Hoseini, Elisa de Stanchina, Nai-Kong V Cheung
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-17 (2024)
Abstract Background EGFR and/or HER2 expression in pancreatic cancers is correlated with poor prognoses. We generated homodimeric (EGFRxEGFR or HER2xHER2) and heterodimeric (EGFRxHER2) T cell-engaging bispecific antibodies (T-BsAbs) to direct polyclo
Externí odkaz:
https://doaj.org/article/dcaf158cf6e446219ea7f5cc9f7a96cb
Autor:
Long, Alan W., Hong Xu, Santich, Brian H., Hongfen Guo, Hoseini, Sayed Shahabuddin, de Stanchina, Elisa, Cheung, Nai-Kong V.
Publikováno v:
Journal of Hematology & Oncology; 4/23/2024, Vol. 17 Issue 1, p1-20, 20p, 5 Charts, 6 Graphs
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
The role of T cells in controlling human cancers is well known. Their success requires continued persistence in vivo and efficient trafficking to tumor sites, requirements shared by other effectors such as Natural Killer (NK) cells. To date, cytokine
Externí odkaz:
https://doaj.org/article/7b9d150a147249fa8b40faf9eab35e07
Publikováno v:
Blood Advances, Vol 2, Iss 11, Pp 1250-1258 (2018)
Abstract: Acute myeloid leukemia (AML), the most common acute leukemia in adults and the second most common cancer in children, is still a lethal disease in the majority of patients, but immunologic approaches have improved outcome. Bispecific antibo
Externí odkaz:
https://doaj.org/article/397332d8798b4e8b868fcd207eb554e9
Supplemental Table S1: Affinities relative to hu3F8-IgG1. Supplemental Table S2: Affinities to both human and mouse FcR(n). Supplemental Figure S1: Kinetic analysis of in vitro binding of antibodies to CD16A(158V) by SPR. Supplemental Figure S2: Bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823cdb67edac31ec2dae8e7259ce0750
https://doi.org/10.1158/2326-6066.22537378.v1
https://doi.org/10.1158/2326-6066.22537378.v1
Anti-disialoganglioside GD2 IgG antibodies have shown clinical efficacy in solid tumors that lack human leukocyte antigens (e.g., neuroblastoma) by relying on Fc-dependent cytotoxicity. However, there are pain side effects secondary to complement act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158d911d368542809723274c8720b1a0
https://doi.org/10.1158/2326-6066.c.6548876.v1
https://doi.org/10.1158/2326-6066.c.6548876.v1
Supplemental Figure S1: Tumor free survival in humanized DKO mice. Supplemental Figure S2: T cell survival in the sc tumors. Supplemental Figure S3: Efficacy of hu3F8-BsAb vs. 5HLDS(15)BA(Y) in humanized DKO mice. Supplemental Figure S4: Cytokine rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131520a5c6dd2ed5360575e6754885f8
https://doi.org/10.1158/2326-6066.22538744
https://doi.org/10.1158/2326-6066.22538744
Autor:
Ronald G. Blasberg, Jason S. Lewis, Howard T. Thaler, Pat B. Zanzonico, Hongfen Guo, Nai-Kong V. Cheung, Ruimin Huang, Hanwen Zhang
Purpose: The norepinephrine transporter (NET) is a critical regulator of catecholamine uptake in normal physiology and is expressed in neuroendocrine tumors like neuroblastoma. Although the norepinephrine analog, meta-iodobenzylguanidine (MIBG), is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abcdb462a1dfbb8f745040c7364379b
https://doi.org/10.1158/1078-0432.c.6521636.v1
https://doi.org/10.1158/1078-0432.c.6521636.v1
Autor:
Ronald G. Blasberg, Jason S. Lewis, Howard T. Thaler, Pat B. Zanzonico, Hongfen Guo, Nai-Kong V. Cheung, Ruimin Huang, Hanwen Zhang
MATERIALS AND METHODS Table S1. Biodistribution of [18F]-MFBG in neuroblastoma xenografts. Table S2. Biodistribution of 123I-MIBG in neuroblastoma xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9feb8a143827ea1154129382b80b9b6c
https://doi.org/10.1158/1078-0432.22449371
https://doi.org/10.1158/1078-0432.22449371
Autor:
Ronald G. Blasberg, Jason S. Lewis, Howard T. Thaler, Pat B. Zanzonico, Hongfen Guo, Nai-Kong V. Cheung, Ruimin Huang, Hanwen Zhang
PDF file - 85KB, Table S1. Biodistribution of 18F-MFBG in neuroblastoma xenografts. Table S2. Biodistribution of 123I-MIBG in neuroblastoma xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061e2dfd52ff83fbb00df156d19d483f
https://doi.org/10.1158/1078-0432.22449368.v1
https://doi.org/10.1158/1078-0432.22449368.v1