Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Hongen Zhang"'
Publikováno v:
eLife, Vol 12 (2024)
Initiating translation of most eukaryotic mRNAs depends on recruitment of methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2) to the small (40S) ribosomal subunit, forming a 43S preiniti
Externí odkaz:
https://doaj.org/article/bf7e64a34aed47fe943320241c4589a0
Autor:
Sahar Melamed, Aixia Zhang, Michal Jarnik, Joshua Mills, Aviezer Silverman, Hongen Zhang, Gisela Storz
Publikováno v:
eLife, Vol 12 (2023)
Flagella are important for bacterial motility as well as for pathogenesis. Synthesis of these structures is energy intensive and, while extensive transcriptional regulation has been described, little is known about the posttranscriptional regulation.
Externí odkaz:
https://doaj.org/article/7d6a3952342c403b8ebaf40b1a269605
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106301- (2023)
Summary: Thyroid hormone (T3) regulates vertebrate organ development, growth, and metabolism through the T3 receptor (TR). Due to maternal influence in mammals, it has been difficult to study if and how T3 regulates liver development. Liver remodelin
Externí odkaz:
https://doaj.org/article/65333bd9ca364ccda83c18c29600f0bd
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Tanizaki et al use ChIP-Seq to identify over 3000 Thyroid hormone (T3) receptor (TR)-bound genes in the intestine of premetamorphic wild type Xenopus tropicalis tadpoles and in TRα-knockouts. They show that treatment of tadpoles with cell cycle inhi
Externí odkaz:
https://doaj.org/article/cb0feff07804433abbe48613e9225b4b
Autor:
Shardul D. Kulkarni, Fujun Zhou, Neelam Dabas Sen, Hongen Zhang, Alan G. Hinnebusch, Jon R. Lorsch
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-27 (2019)
Abstract Background Translation of an mRNA in eukaryotes starts at an AUG codon in most cases, but near-cognate codons (NCCs) such as UUG, ACG, and AUU can also be used as start sites at low levels in Saccharomyces cerevisiae. Initiation from NCCs or
Externí odkaz:
https://doaj.org/article/6bebc927b4e24df7b84f02d6436faaa8
Autor:
Hongen Zhang, Lang Li, Prabir Kumar Sarker, Tao Long, Xiaoshuang Shi, Qingyuan Wang, Gaochuang Cai
Publikováno v:
International Journal of Concrete Structures and Materials, Vol 13, Iss 1, Pp 1-18 (2019)
Abstract This work quantified the hierarchy of the influence of three common mixture design parameters on the compressive strength and the rate of strength increase over the long term of low-calcium fly ash geopolymer concrete (FAGC) through designin
Externí odkaz:
https://doaj.org/article/7837dbca985f40d9bab9947ca884117c
Autor:
Swati Gaikwad, Fardin Ghobakhlou, David J Young, Jyothsna Visweswaraiah, Hongen Zhang, Alan G Hinnebusch
Publikováno v:
eLife, Vol 10 (2021)
In eukaryotes, 43S preinitiation complex (PIC) formation is a rate-determining step of translation. Ribosome recycling following translation termination produces free 40S subunits for re-assembly of 43S PICs. Yeast mutants lacking orthologs of mammal
Externí odkaz:
https://doaj.org/article/e39deb7ff5ef4afcb85e31f01fb99d02
Autor:
Si Young Lee, Stevephen Hung, Caroline Esnault, Rakesh Pathak, Kory R. Johnson, Oluwadamilola Bankole, Akira Yamashita, Hongen Zhang, Henry L. Levin
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2686-2698.e8 (2020)
Summary: Heterochromatin functions as a scaffold for factors responsible for gene silencing and chromosome segregation. Heterochromatin can be assembled by multiple pathways, including RNAi and RNA surveillance. We identified factors that form hetero
Externí odkaz:
https://doaj.org/article/74e98dc7dde943b3b38d3262c02bac87
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1223 (2022)
Thyroid hormone (T3) receptors (TRs) mediate T3 effects on vertebrate development. We have studied Xenopus tropicalis metamorphosis as a model for postembryonic human development and demonstrated that TRα knockout induces precocious hind limb develo
Externí odkaz:
https://doaj.org/article/0a008f665ffd48ff87106c2ad8fb95ff
Publikováno v:
Microorganisms, Vol 9, Iss 12, p 2413 (2021)
Ded1 is an essential DEAD-box helicase in yeast that broadly stimulates translation initiation and is critical for mRNAs with structured 5′UTRs. Recent evidence suggests that the condensation of Ded1 in mRNA granules down-regulates Ded1 function du
Externí odkaz:
https://doaj.org/article/07ede20327e64718a7ce3da36199b807