Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hongchul Yoon"'
Autor:
Jongmin Yoon, Haengjin Song, Ji Soo Park, Jeong Ho Kim, Yearin Jun, Sang-Ah Gim, Changhee Hong, Kyung Mi An, Joon-Tae Park, Jung Woo Lee, Hongchul Yoon, Yun Seok Kim, Sang Geon Kim
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 181, Iss , Pp 117674- (2024)
Fasiglifam, a candidate targeting GPR40, showed efficacy in clinical trials for type 2 diabetes but exerted liver toxicity. This study investigated the drug-induced liver injury (DILI) risk of Xelaglifam, a new GPR40 agonist, based on the potential t
Externí odkaz:
https://doaj.org/article/5b33b002220347abbfd3cdadb7d8639d
Autor:
Jongmin Yoon, Don-Gil Lee, Haengjin Song, Dahae Hong, Ji Soo Park, Changhee Hong, Kyung Mi An, Jung Woo Lee, Joon-Tae Park, Hongchul Yoon, Jihoon Tak, Sang Geon Kim
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117044- (2024)
Xelaglifam, developed as a GPR40/FFAR1 agonist, induces glucose-dependent insulin secretion and reduces circulating glucose levels for Type 2 diabetes treatment. This study investigated the effects of Xelaglifam in comparison with Fasiglifam on the i
Externí odkaz:
https://doaj.org/article/ba1ea162fd884b25ab82e6eb1a5aff1e
Autor:
Bo Yi Kim, Changmok Oh, Dongkyu Jeon, Ikhyun Jun, Ho K. Lee, Bo-Rahm Kim, Jinhong Park, Kyoung Yul Seo, Kyeong-A Kim, Dami Lim, Seolhee Lee, Jooyun Lee, Hongchul Yoon, Tae-im Kim, Wan Namkung
Publikováno v:
Journal of Medicinal Chemistry. 66:413-434
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b57589b4a7a78277af1d1591aca7f624
https://doi.org/10.1021/acs.jmedchem.2c01382
https://doi.org/10.1021/acs.jmedchem.2c01382
Autor:
Dongkyu Jeon, Ikhyun Jun, Ho K. Lee, Jinhong Park, Bo-Rahm Kim, Kunhi Ryu, Hongchul Yoon, Tae-im Kim, Wan Namkung
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 5206
Cystic fibrosis transmembrane conductance regulator (CFTR) is highly expressed on the ocular epithelium and plays a pivotal role in the fluid secretion driven by chloride transport. Dry eye disease is one of the most common diseases with limited ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33173756da922783bb18b8054175b09f
https://pubmed.ncbi.nlm.nih.gov/35563597
https://pubmed.ncbi.nlm.nih.gov/35563597
Autor:
Sohn Te-Ik, Yeongran Yoo, Ilji Jeong, Jin Hee Lee, Jeewoo Lee, Jihyae Ann, Jae Eui Shin, Kyusic Jang, Hongchul Yoon, Jung Ju-Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 40:127963
Human indoleamine 2,3-dioxygenase 1 (hIDO1) and tryptophan dioxygenase (hTDO) are rate-limiting enzymes in the kynurenine pathway (KP) of l -tryptophan ( l -Trp) metabolism and are becoming key drug targets in the combination therapy of checkpoint in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd0286989bd8862505e3c02331fed06
https://doi.org/10.1016/j.bmcl.2021.127963
https://doi.org/10.1016/j.bmcl.2021.127963
Autor:
Jee Sun Yang, Myung Hwa Kim, Bo Young Joe, Jung Eun Park, Kwangwoo Chun, Doona Song, Jong Hee Choi, J W Seo, Chun Ho Park, Hongchul Yoon, Gyoonhee Han, Misun Cho
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:8618-8629
A series of coumarin based TACE inhibitors were designed to bind in S1' pocket of TACE enzyme based on their docking study. Twelve analogues were synthesized and most of compounds were active in vitro TACE enzyme inhibition as well as cellular TNF-α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e4b94c496ec95b592cb4d4e97e64e4
https://doi.org/10.1016/j.bmc.2010.10.006
https://doi.org/10.1016/j.bmc.2010.10.006