Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Hongchao He"'
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e34877- (2024)
Background: CTLA4, an immune checkpoint, plays an important role in tumor immunotherapy. The purpose of this study was to develop a pathomics signature to evaluate CTLA4 expression and predict clinical outcomes in clear cell renal cell carcinoma (ccR
Externí odkaz:
https://doaj.org/article/4f40c7ddd1a74cb38f0bfd8dfd5fc8fa
Autor:
Jie Cheng, Hanqing Liu, Yan Shen, Jiawei Ding, Hongchao He, Shilong Mao, Li Chen, Chuanjie Zhang, Jian Zhou
Publikováno v:
Translational Oncology, Vol 45, Iss , Pp 101987- (2024)
Background: Bevacizumab resistance poses barriers to targeted therapy in clear cell renal cell carcinoma (ccRCC). Whether there exist epigenetic targets that modulate bevacizumab sensitivity in ccRCC remains indefinite. The focus of this study is to
Externí odkaz:
https://doaj.org/article/0768daf21a564f3090cb8120882adf5d
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Aberrant interplay between epigenetic reprogramming and hypoxia signaling contributes to renal cell carcinoma progression and drug resistance, which is an essential hallmark. How the chromatin remodelers enhance RCC malignancy rem
Externí odkaz:
https://doaj.org/article/a3aed35667244b29977c73b06ca39ef5
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 7627-7638 (2023)
Abstract Objectives To predict CTLA4 expression levels and prognosis of clear cell renal cell carcinoma (ccRCC) by constructing a computed tomography‐based radiomics model and establishing a nomogram using clinicopathologic factors. Methods The cli
Externí odkaz:
https://doaj.org/article/f01e8cd09d704ba79a02fe30f6a8a51f
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Loss-of-function mutations or abnormal expressions of E ubiquitin ligases contributes to tumorigenesis. TRIM38 was reported to regulate immunity, inflammatory responses or apoptosis, but its roles in tumor progression remain incon
Externí odkaz:
https://doaj.org/article/49b53acc13fa4120a84e1f2d5f7acede
Targeting POLE2 Creates a Novel Vulnerability in Renal Cell Carcinoma via Modulating Stanniocalcin 1
Autor:
Chuanjie Zhang, Yan Shen, Lili Gao, Xiaojing Wang, Da Huang, Xin Xie, Danfeng Xu, Hongchao He
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
ObjectiveThe aim of this study is to investigate the biological functions and the underlying mechanisms of DNA polymerase epsilon subunit 2 (POLE2) in renal cell carcinoma (RCC).MethodsThe datasets of POLE2 expression in The Cancer Genome Atlas Kidne
Externí odkaz:
https://doaj.org/article/c0f6e8d2074f48bf943a81067fa6e9cd
Autor:
Chuanjie Zhang, Xuan Lu, Jingyi Huang, Hongchao He, Li Chen, Yihan Liu, Haofei Wang, Yang Xu, Siwei Xing, Xiaohao Ruan, Xiaoqun Yang, Lu Chen, Danfeng Xu
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 2, Pp n/a-n/a (2021)
Abstract Aberrant epigenetic reprogramming represents a hallmark of renal cell carcinoma (RCC) tumorigenesis and progression. Whether there existed other epigenetic vulnerabilities that could serve as therapeutic targets remained unclear and promisin
Externí odkaz:
https://doaj.org/article/27033e7db92049abbca287f0c6c6ce48
Autor:
Xin Xie MM, Hongchao He PhD, Ning Zhang MD, Xiaojing Wang MD, Wenbin Rui MD, Danfeng Xu MD, Yu Zhu MD
Publikováno v:
Technology in Cancer Research & Treatment, Vol 19 (2020)
Purpose: Discoidin domain receptor 1 (DDR1) belongs to a novel class of receptor tyrosine kinases. Previous evidence indicates that DDR1 overexpression promotes the aggressive growth of bladder cancer (BC) cells. This study aimed to investigate the m
Externí odkaz:
https://doaj.org/article/86d362a7955f4183ba84f16b5c1332e0
Autor:
Haofei Wang, Fangxiu Luo, Zhe Zhu, Zhaoping Xu, Xin Huang, Renyi Ma, Hongchao He, Yu Zhu, Kun Shao, Juping Zhao
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-7 (2017)
Abstract Background ATP-binding cassette sub-family G member 2 (ABCG2) is a semi-transport protein that plays a major role in multidrug resistance. We aimed to evaluate the prognostic significance of ABCG2 expression in patients with clear cell renal
Externí odkaz:
https://doaj.org/article/b00b648b77b4463da901d21609f7fc3b