Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Hongchang, Qu"'
Autor:
Zhixiong Ying, Robin van Eenige, Xiaoke Ge, Christy van Marwijk, Joost M. Lambooij, Bruno Guigas, Martin Giera, Jan Freark de Boer, Tamer Coskun, Hongchang Qu, Yanan Wang, Mariëtte R. Boon, Patrick C.N. Rensen, Sander Kooijman
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104684- (2023)
Summary: Background: Combined glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP1R) agonism is superior to single GLP1R agonism with respect to glycemic control and weight loss in obese patients wit
Externí odkaz:
https://doaj.org/article/d8ae3b6711e4498db0d081190af4e7ce
Autor:
Haitao Hu, Anthony S. Ransdell, Hongchang Qu, Jim D. Durbin, Francisco A. Valenzuela, Selene Hernandez-Buquer, Malgorzata D. Gonciarz
Publikováno v:
ACS Chemical Biology. 18:1158-1167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31590cbe8485263e848df4a2a2d6118f
https://doi.org/10.1021/acschembio.3c00018
https://doi.org/10.1021/acschembio.3c00018
Autor:
Tamer Coskun, Shweta Urva, William C. Roell, Hongchang Qu, Corina Loghin, Julie S. Moyers, Libbey S. O’Farrell, Daniel A. Briere, Kyle W. Sloop, Melissa K. Thomas, Valentina Pirro, David B. Wainscott, Francis S. Willard, Matthew Abernathy, LaRonda Morford, Yu Du, Charles Benson, Ruth E. Gimeno, Axel Haupt, Zvonko Milicevic
Publikováno v:
Cell metabolism. 34(9)
With an increasing prevalence of obesity, there is a need for new therapies to improve body weight management and metabolic health. Multireceptor agonists in development may provide approaches to fulfill this unmet medical need. LY3437943 is a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0680405a26fc0854e942b2516c1cf62a
https://pubmed.ncbi.nlm.nih.gov/35985340
https://pubmed.ncbi.nlm.nih.gov/35985340
Autor:
David B. Wainscott, Francis S. Willard, Fariba Norouziyan Cooper, James Ficorilli, Kyle W. Sloop, Jorge Alsina-Fernandez, William C. Roell, Tamer Coskun, Over Cabrera, Shweta Urva, Aaron D. Showalter, Libbey S. O’Farrell, Xiaoping Ruan, Hongchang Qu, Julie S. Moyers, Ajit Regmi, Lili Guo
Publikováno v:
Diabetes. 70
The ever-growing prevalence of obesity and its associated comorbidities (T2D, NASH/NAFLD) is driving the need to discover new therapies for improving metabolic health. Recently, multi-receptor agonists have offered promise for meeting this need. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce73da18004f9da5ae151ab81bea87dc
https://doi.org/10.2337/db21-679-p
https://doi.org/10.2337/db21-679-p
Autor:
Krister Bokvist, Yanyun Chen, Julie S. Moyers, Mezo Adam Robert, Melissa K. Thomas, Tamer Coskun, Min Song, William C. Roell, Valenzuela Francisco Alcides, Hongchang Qu
Publikováno v:
Diabetes. 70
LY3305677 (LY) is a synthetic peptide analog of mammalian oxyntomodulin with a fatty acyl side chain to extend time action. LY functions are mediated by binding and activation of both glucagon (GcgR) and glucagon-like peptide-1 (GLP-1R) receptors. LY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa273a6e8b63606b2790d9ac363a0bf1
https://doi.org/10.2337/db21-682-p
https://doi.org/10.2337/db21-682-p
Autor:
Yuji Teramura, John D. Lambris, Bo Nilsson, Peetra U. Magnusson, Kristina Nilsson Ekdahl, Daniel Ricklin, Hongchang Qu, Hiroo Iwata, Per H. Nilsson, Jaan Hong
Publikováno v:
Biomaterials
Activation of the thrombotic and complement systems is the main recognition and effector mechanisms in the multiple adverse biological responses triggered when biomaterials or therapeutic cells come into blood contact. We have created a surface which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bb41fc89a39098634f328d3f65e1f0
https://doi.org/10.1016/j.biomaterials.2012.10.040
https://doi.org/10.1016/j.biomaterials.2012.10.040
Autor:
Sumeena Bhatia, Daniel I. Simon, Sven G. Meuth, Kerstin Göbel, Hongchang Qu, Kenneth E. Hill, Paul Kubes, Kyoung-Jin Chung, Rebecca Schleicher, Triantafyllos Chavakis, Michael J. Kruhlak, Yongqing Zhang, Antonios Chatzigeorgiou, John D. Lambris, Connie H.Y. Wong, Kevin G. Becker, Xuri Li, Hong Zhou, Bernhard Nieswandt, Harald F. Langer, Zhongshu Tang, Eun-Young Choi, John W. Rose, Khalil Bdeir, James Burns, Elin Lehrmann, Yunmei Wang
Publikováno v:
Circulation Research. 110:1202-1210
Rationale: Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are inflammatory disorders of the central nervous system (CNS). The function of platelets in inflammatory and autoimmune pathologies is thus far
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d404ebce2cc0bf0bec0114742601b9
https://doi.org/10.1161/circresaha.111.256370
https://doi.org/10.1161/circresaha.111.256370
Autor:
Xuyuan Gu, Sukeshi J. Mehta, Bryan Grossman, Gary S. Nichol, Victor J. Hruby, Hongchang Qu, Zhihua Liu, Kwang Soo Lee
Publikováno v:
The Journal of Organic Chemistry. 77:1289-1300
Multifunctionalized amino acids, especially amino acids with unsaturation, are important, demanding building blocks in peptide chemistry. Here we present a summary of our most recent study using the thio-Claisen rearrangement for the synthesis of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6a5bb1ddc55fdcee9f271cab683204
https://doi.org/10.1021/jo201753q
https://doi.org/10.1021/jo201753q
Autor:
Hongchang Qu, Daniel Ricklin, Emilia L. Wu, Ioannis Kourtzelis, You-Qiang Wu, John D. Lambris, Paola Magotti, Yiannis N. Kaznessis
Publikováno v:
Molecular Immunology. 48:481-489
Compstatin is a 13-residue disulfide-bridged peptide that inhibits a key step in the activation of the human complement system. Compstatin and its derivatives have shown great promise for the treatment of many clinical disorders associated with unbal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdace9fceec534284e40668da1cbd85
https://doi.org/10.1016/j.molimm.2010.10.004
https://doi.org/10.1016/j.molimm.2010.10.004
Publikováno v:
Molecular Immunology. 47:185-195
As a key part of the innate immune system, complement plays an important role not only in defending against invading pathogens but also in many other biological processes. Inappropriate or excessive activation of complement has been linked to many au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da3c31cae91525e796d2ce578c250af
https://doi.org/10.1016/j.molimm.2009.08.032
https://doi.org/10.1016/j.molimm.2009.08.032