Zobrazeno 1 - 10
of 583
pro vyhledávání: '"Hongbing, Zhang"'
Autor:
Zihe Zhang, Yongwen Li, Ruifeng Shi, Chaoyi Jia, Songlin Xu, Guangsheng Zhu, Peijun Cao, Hua Huang, Xuanguang Li, Hongbing Zhang, Minghui Liu, Chen Chen, Hongyu Liu, Chunsheng Kang, Jun Chen
Publikováno v:
Cell Death and Disease, Vol 15, Iss 9, Pp 1-14 (2024)
Abstract Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (EGFR-TKI) approved for patients with EGFR T790M resistance mutations as first- or second-line treatment of EGFR-positive patients. Resistanc
Externí odkaz:
https://doaj.org/article/6cd58d2ae3984a0ea93766d76679bcb3
Autor:
Guangsheng Zhu, Yanan Wang, Yingjie Wang, Hua Huang, Boshi Li, Peijie Chen, Chen Chen, Hongbing Zhang, Yongwen Li, Hongyu Liu, Jun Chen
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-13 (2024)
Abstract Lung cancer is a leading cause of cancer-related mortality globally, with a dismal 5-year survival rate, particularly for Lung Adenocarcinoma (LUAD). Mechanical changes within the tumor microenvironment, such as extracellular matrix (ECM) re
Externí odkaz:
https://doaj.org/article/0e3e54da3a96473ea73b41bcc6512931
Autor:
Zixi Wang, Huaiyuan Zong, Weiwei Liu, Wei Lin, Anjiang Sun, Zhao Ding, Xu Chen, Xiaofeng Wan, Yanyan Liu, Zhongdong Hu, Hongbing Zhang, Hongwu Li, Yehai Liu, Dapeng Li, Sumei Zhang, Xiaojun Zha
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)
Abstract Background The dysregulated mechanistic target of rapamycin complex 1 (mTORC1) signaling plays a critical role in ferroptosis resistance and tumorigenesis. However, the precise underlying mechanisms still need to be fully understood. Methods
Externí odkaz:
https://doaj.org/article/bddf02bc52074441a2ce5fd662fbebd1
Autor:
Fuqiang Huang, Jing Guo, Na Zhao, Mengjie Hou, Xiaochen Gai, Shuhui Yang, Pei Cai, Yanan Wang, Qian Ma, Qi Zhao, Li Li, Huayu Yang, Yanling Jing, Di Jin, Zhongdong Hu, Xiaojun Zha, Hongyang Wang, Yilei Mao, Fangming Liu, Hongbing Zhang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Although hepatitis B virus (HBV) infection is a major risk factor for hepatic cancer, the majority of HBV carriers do not develop this lethal disease. Additional molecular alterations are thus implicated in the process of liver tu
Externí odkaz:
https://doaj.org/article/fcae3e2c4b5f427887e202af29fbad5f
Autor:
Fangming Liu, Yuting Wu, Baohui Zhang, Shuhui Yang, Kezhuo Shang, Jie Li, Pengju Zhang, Weiwei Deng, Linlin Chen, Liang Zheng, Xiaochen Gai, Hongbing Zhang, Jing Ni
Publikováno v:
Chinese Medical Journal, Vol 137, Iss 2, Pp 181-189 (2024)
Abstract. Background:. Liver cancer is largely resistant to chemotherapy. This study aimed to identify the effective chemotherapeutics for β-catenin-activated liver cancer which is caused by gain-of-function mutation of catenin beta 1 (CTNNB1), the
Externí odkaz:
https://doaj.org/article/a44d8ab78eb44fd2b839a2b9b0332a41
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 2, Pp 309-315 (2024)
Macrophage migration inhibitory factor (MIF), a multifunctional cytokine, is secreted by various cells and participates in inflammatory reactions, including innate and adaptive immunity. There are some evidences that MIF is involved in many vitreoret
Externí odkaz:
https://doaj.org/article/650bc3313e0047faabe713f7df2d2e8e
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116424- (2024)
The prevalence of retinal degenerative diseases, including age-related macular degeneration and retinitis pigmentosa, has been increasing globally and is linked to the aging population and improved life expectancy. These diseases are characterized by
Externí odkaz:
https://doaj.org/article/2cb94196bbe74b89b803c0c013a732bb
Publikováno v:
环境与职业医学, Vol 40, Iss 12, Pp 1411-1418 (2023)
BackgroundNoise and dust are the most widespread occupational hazards. Animal studies have shown that they may cause impaired fasting glucose (IFG) by disturbing glucose metabolism and impairing the function of pancreatic islet cells, which can lead
Externí odkaz:
https://doaj.org/article/d860313f44df41f199205fd42bd73d8c
Autor:
Minghui Liu, Xin Li, Hongbing Zhang, Fan Ren, Jinghao Liu, Yongwen Li, Ming Dong, Honglin Zhao, Song Xu, Hongyu Liu, Jun Chen
Publikováno v:
Cancer Medicine, Vol 12, Iss 24, Pp 21735-21741 (2023)
Abstract Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKI) acquired resistance was an inevitably events in NSCLC treatment. Aims Intending to overcome the acquired resistance of EGFR‐TKI. Materials & Methods A clin
Externí odkaz:
https://doaj.org/article/750afa4493734bcaabe47594c07f1a19
Autor:
Jun Wei, Min Li, Zhi Ye, Xinqian Hu, Xiaoyan He, Jia Wang, Gaofeng Chen, Chengyu Zou, Daichao Xu, Hongbing Zhang, Junying Yuan, Yunhong Zha
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-8 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a devastating fatal neurodegenerative disease with no cure. Receptor-interacting protein kinase 1 (RIPK1) has been proposed to mediate pathogenesis of ALS. Primidone has been identified as an old drug t
Externí odkaz:
https://doaj.org/article/fd2d653320c74250abdbdb166c739388