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Akademický článek

Brain structures as potential mediators of the causal effect of COVID 19 on migraine risk

Autor: Hongbei Xu, Wei Chen, Yaxin Ju, Hongqun Chen, Ping Yuan, Fu Ouyang

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Migraine is a common neurological disorder observed after coronavirus disease 2019 (COVID 19) infection. However, the intricate relationship between COVID 19 and migraine, particularly the potential mediating role of brain imaging-derived ph

Externí odkaz: https://doaj.org/article/c4f01ae9bdab4e3484f4ff496c5de8ab

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Akademický článek

Alzheimer’s disease as a causal risk factor for diabetic retinopathy: a Mendelian randomization study

Autor: Fu Ouyang, Ping Yuan, Yaxin Ju, Wei Chen, Zijun Peng, Hongbei Xu

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

ObjectivesThis study aims to investigate the causal relationship between Alzheimer’s Disease (AD) and Diabetic Retinopathy (DR).MethodsEmploying Mendelian Randomization (MR), Generalized Summary-data-based Mendelian Randomization (GSMR), and the MR

Externí odkaz: https://doaj.org/article/b4f4b61cc0124e4aa3d532b4cd3fd582

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Akademický článek

The association between epilepsy and COVID-19: analysis based on Mendelian randomization and FUMA

Autor: Mingyao You, Ping Yuan, Liangqian Li, Baoduo Li, Zijun Peng, Hongbei Xu

Publikováno v: Frontiers in Neuroscience, Vol 17 (2023)

ObjectiveA multitude of observational studies have underscored a substantial comorbidity between COVID-19 and epilepsy. This study was aimed at establishing a conclusive causal link between these two conditions.MethodsWe employed Mendelian randomizat

Externí odkaz: https://doaj.org/article/2116fe07e86a415da30b96f8ec6995af

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Akademický článek

HIF-1 signalling pathway was identified as a potential new pathway for Icariin’s treatment against Alzheimer’s disease based on preclinical evidence and bioinformatics

Autor: Mingyao You, Ping Yuan, Liangqian Li, Hongbei Xu

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Aim: Alzheimer’s disease (AD) is a neurodegenerative condition that is characterized by the gradual loss of memory and cognitive function. Icariin, which is a natural chemical isolated from Epimedii herba, has been shown to protect against AD. This

Externí odkaz: https://doaj.org/article/51367e8f72864ea58789bbd402c8a701

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Akademický článek

OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-κB signalling pathway in acute ischaemic stroke rats

Autor: Hongbei Xu, You Wang, Yong Luo

Publikováno v: Molecular Medicine, Vol 27, Iss 1, Pp 1-19 (2021)

Abstract Objective Ovarian tumour domain deubiquitinase with linear linkage specificity (OTULIN) is a potent negative regulator of the nuclear factor-κB (NF-κB) signalling pathway, and it plays a strong neuroprotective role following acute ischemic

Externí odkaz: https://doaj.org/article/b9b9853246514fbeb75c8feec13e62a0

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Akademický článek

Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats

Autor: Hongbei Xu, Wenyi Qin, Xiao Hu, Song Mu, Jun Zhu, Wenhao Lu, Yong Luo

Publikováno v: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-17 (2018)

Abstract Background Ischemic stroke-induced neuroinflammation is mainly mediated by microglial cells. The nuclear factor kappa B (NF-κB) pathway is the key transcriptional pathway that initiates inflammatory responses following cerebral ischemia. OT

Externí odkaz: https://doaj.org/article/3d0dd26ec66647b196cb3e8f08ba4b2a

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OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-κB signalling pathway in acute ischaemic stroke rats

Autor: Yong Luo, Hongbei Xu, You Wang

Publikováno v: Molecular Medicine, Vol 27, Iss 1, Pp 1-19 (2021)
Molecular Medicine

Objective Ovarian tumour domain deubiquitinase with linear linkage specificity (OTULIN) is a potent negative regulator of the nuclear factor-κB (NF-κB) signalling pathway, and it plays a strong neuroprotective role following acute ischemic stroke.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331fdc6ef941b2a44590ffbe7f3524bf
https://doaj.org/article/b9b9853246514fbeb75c8feec13e62a0

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Molecular Mechanism of Epimedium Extract against Ischemic Stroke Based on Network Pharmacology and Experimental Validation

Autor: Hongbei Xu, Mingyao You, Xiang Xiang, Jun Zhao, Ping Yuan, Lan Chu, Chenchen Xie

Publikováno v: Oxidative Medicine and Cellular Longevity.

Ischemic stroke exhibits high morbidity, disability, and mortality, and treatments for ischemic stroke are limited despite intensive research. The potent neuroprotective benefits of Epimedium against ischemic stroke have gained lots of interest. Neve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8afce72084651397574d13820aefb35

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Coexisting amyotrophic lateral sclerosis and chorea: A case report and literature review

Autor: Anni, Zhang, Hongbei, Xu, Jing, Huang, Huilan, Gong, Shipeng, Guo, Xiaoyang, Lei, Dian, He

Publikováno v: Medicine. 101:e32452

Amyotrophic lateral sclerosis (ALS) coexisting with chorea is very rare.We present the case of a 48-year-old man with ALS and chorea; the diagnostic certainty was high based on clinical examination results. Combining the data from literature, we anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5796111df0457b5a903ad57560cefd
https://doi.org/10.1097/md.0000000000032452

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