Zobrazeno 1 - 10
of 217
pro vyhledávání: '"HongZhen Hu"'
Autor:
Zhihui He, Yonghui Zhao, Michael J. Rau, James A. J. Fitzpatrick, Rajan Sah, Hongzhen Hu, Peng Yuan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
The PANX2 channel is involved in skin homeostasis and neuronal development, but the molecular basis of channel function remains largely unknown. Here, the authors provide detailed analysis of the structure, function, and pharmacology of human PANX2.
Externí odkaz:
https://doaj.org/article/a3925cea2fa94b43a3755583b41c6230
Autor:
Jameson P. Holloman, Sophia H. Dimas, Angela S. Archambault, Fabia Filipello, Lixia Du, Jing Feng, Yonghui Zhao, Bryan Bollman, Laura Piccio, Andrew J. Steelman, Hongzhen Hu, Gregory F. Wu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 17097 (2023)
Microglia are found pathologically at all stages of multiple sclerosis (MS) lesion development and are hypothesized to contribute to both inflammatory injury and neuroprotection in the MS brain. Transient receptor potential vanilloid 4 (TRPV4) channe
Externí odkaz:
https://doaj.org/article/f81cf5d4d9fb493aa25347ce8632179b
Autor:
Xueming Hu, Lixia Du, Shenbin Liu, Zhou Lan, Kaikai Zang, Jing Feng, Yonghui Zhao, Xingliang Yang, Zili Xie, Peter L. Wang, Aaron M. Ver Heul, Lvyi Chen, Vijay K. Samineni, Yan-Qing Wang, Kory J. Lavine, Robert W. Gereau IV, Gregory F. Wu, Hongzhen Hu
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
Microglia, resident macrophages of the CNS, are essential to brain development, homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS diseases, including neuropathic pain. However, molecular mechanisms that gover
Externí odkaz:
https://doaj.org/article/9981ba42e1df4b6f95aaa052ae104eca
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
In the past few years, there has been extraordinary interest in how the gut communicates with the brain. This is because substantial and gathering data has emerged to suggest that sensory nerve pathways between the gut and brain may contribute much m
Externí odkaz:
https://doaj.org/article/fb58454f6802482f82688931f29a09e5
Autor:
Nick J. Spencer, Lee Travis, Lukasz Wiklendt, Marcello Costa, Timothy J. Hibberd, Simon J. Brookes, Phil Dinning, Hongzhen Hu, David A. Wattchow, Julian Sorensen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Nick Spencer et al. made simultaneous multi-site electrophysiological recordings with video imaging of colonic wall movements from ex vivo mouse colon, in order to correlate propulsion of content with underlying electrical signals from the smooth mus
Externí odkaz:
https://doaj.org/article/8d074c84cd8c46d598041d4005601ffc
Publikováno v:
Actuators, Vol 12, Iss 3, p 121 (2023)
The current vehicle stability judgment methods in the stability control of distributed drive electric vehicles focuses on using the phase plane method, but the existing phase plane stability boundary delineation methods ignore the influence of the fr
Externí odkaz:
https://doaj.org/article/2a5258ae12ec408b9024be33d422c401
Autor:
William R. Arnold, Lauren N. Carnevale, Zili Xie, Javier L. Baylon, Emad Tajkhorshid, Hongzhen Hu, Aditi Das
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Endocannabinoids are ligands of cannabinoid receptors and a promising target for pain management. Here, the authors report a class of lipids formed by the epoxidation of N-arachidonoyl dopamine and N-arachidonoyl serotonin by cytochrome P450 epoxygen
Externí odkaz:
https://doaj.org/article/e9b14b21f1074585aeec1d71675686bb
Autor:
Zili Xie, Jing Feng, Tao Cai, Ronald McCarthy, Mark D. Eschbach II, Yuhui Wang, Yonghui Zhao, Zhihua Yi, Kaikai Zang, Yi Yuan, Xueming Hu, Fengxian Li, Qin Liu, Aditi Das, Sarah K. England, Hongzhen Hu
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Pain emanating from the female reproductive tract is notoriously difficult to treat, and the prevalence of transient pelvic pain has been placed as high as 70%–80% in women surveyed. Although sex hormones, especially estrogen, are thought to underl
Externí odkaz:
https://doaj.org/article/1e3179dd5f3f45ad820c9ae4eb63a426
Autor:
Jing Feng, Tim J. Hibberd, Jialie Luo, Pu Yang, Zili Xie, Lee Travis, Nick J. Spencer, Hongzhen Hu
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
How the enteric nervous system determines the pacing and propagation direction of neurogenic contractions along the colon remains largely unknown. We used a chemogenetic strategy to ablate enteric neurons expressing calretinin (CAL). Mice expressing
Externí odkaz:
https://doaj.org/article/6f0a1fba26bb45d4b033a8f1faa295fb
Autor:
Fengxian Li, Weishan Yang, Haowu Jiang, Changxiong Guo, Andrew J. W. Huang, Hongzhen Hu, Qin Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The eye shows protective responses to noxious stimuli including cold. Here, the authors show that TRPV1, found co-expressed on TRPM8 + fibres in the cornea, is necessary for cold nociception in the eye.
Externí odkaz:
https://doaj.org/article/d4a8ad404f0d41f385e2f421e1c4bb80