Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hong-qiu He"'
Publikováno v:
Molecules, Vol 15, Iss 3, Pp 1903-1917 (2010)
Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide deriv
Externí odkaz:
https://doaj.org/article/c7765507507942be927e67672cd9c8ab
Publikováno v:
Journal of Chemistry, Vol 2015 (2015)
Euphorbia factor L713283 is a new lathyrane diterpene isolated from Euphorbia lathyris and shows strong anticancer activity. By using molecular similarity analysis, β-tubulin was identified as one of the possible targets of L713283. We further inves
Externí odkaz:
https://doaj.org/article/b559f8ba6f26404e8f1e276fd1404fc2
Publikováno v:
Archiv der Pharmazie. 348:206-213
In this publication, we design and report the synthesis of calix[4]arene-based β-diketo derivatives as novel HIV-1 integrase (IN) inhibitors. The target compounds were obtained using Claisen condensation, and their structures were characterized by N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e56d62e858b5ca17728d67d8e4fbd2fe
https://doi.org/10.1002/ardp.201400390
https://doi.org/10.1002/ardp.201400390
Publikováno v:
Chinese Chemical Letters. 25:737-740
A series of novel calix[4]arene derivatives incorporating two triazolyl 1,3-diketo subunits in alternate positions at the lower rim were synthesized and screened for HIV integrase inhibition activity. The chemical structures of these compounds were c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0014f47e63441b5337cc581fc75bb94f
https://doi.org/10.1016/j.cclet.2014.03.012
https://doi.org/10.1016/j.cclet.2014.03.012
Autor:
Zi-Guo Jiao jiaoziguo@emails.bjut.edu.cn, Hong-Qiu He, Cheng-Chu Zeng1 zengcc@bjut.edu.cn, Jian-Jun Tan1, Li-Ming Hu, Cun-Xin Wang1 cxwang@bjut.edu.cn
Publikováno v:
Molecules. Mar2010, Vol. 15 Issue 3, p1903-1917. 15p. 3 Diagrams, 2 Charts.
Publikováno v:
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS. 36:1146-1153
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::630b9641b7c898b12bfa8cdc1870f0c4
https://doi.org/10.3724/sp.j.1206.2009.00126
https://doi.org/10.3724/sp.j.1206.2009.00126
Publikováno v:
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS. 36:592-600
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a9aeb48a2658c5cf561e1a6e80af1e1
https://doi.org/10.3724/sp.j.1206.2008.00656
https://doi.org/10.3724/sp.j.1206.2008.00656
Publikováno v:
Chinese Chemical Letters. 20:789-792
A series of novel 6-sulfamoyl-4-oxoquinoline-3-carboxylic acids derivatives have been synthesized and screened for HIV integrase inhibition activity. Their structures were confirmed by ESI-MS, 1H NMR and 13C NMR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de4ea90ce1f7489af7481c1c2a319595
https://doi.org/10.1016/j.cclet.2009.03.014
https://doi.org/10.1016/j.cclet.2009.03.014
Publikováno v:
Scientific Reports
Human immunodeficiency virus (HIV)-1 integrase (IN), which mediates integration of viral cDNA into the cellular chromosome, is a validated antiviral drug target. Three IN inhibitors, raltegravir, elvitegravir and dolutegravir, have been clinically ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28449bf7c56715baad2f4829e1bd3e06
https://pubmed.ncbi.nlm.nih.gov/27137477
https://pubmed.ncbi.nlm.nih.gov/27137477
Autor:
Shan Chang, Qing Hua Zhang, Wei Zu Chen, Xinqi Gong, Chun Hua Li, Xiao Hui Ma, Longzhu Q. Shen, Bin Liu, Ming Hui Wang, Cun Xin Wang, Hong Qiu He
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 69:859-865
Protein–protein docking is usually exploited with a two-step strategy, i.e., conformational sampling and decoy scoring. In this work, a new filter enhanced sampling scheme was proposed and added into the RosettaDock algorithm to improve the conform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::136cd1596956f2e05fd593fff4915da5
https://doi.org/10.1002/prot.21738
https://doi.org/10.1002/prot.21738