Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Hong-lian Wang"'
Autor:
Yuan-Xia Zou, Jiraporn Kantapan, Hong-Lian Wang, Jian-Chun Li, Hong-Wei Su, Jian Dai, Nathupakorn Dechsupa, Li Wang
Publikováno v:
Regenerative Therapy, Vol 28, Iss , Pp 169-182 (2025)
Background: Acute kidney injury (AKI) is a life-threatening clinical syndrome with no effective treatment currently available. This study aims to investigate whether Iron-Quercetin complex (IronQ) pretreatment can enhance the therapeutic efficacy of
Externí odkaz:
https://doaj.org/article/60c151d30f57414db57080afca1aff71
Autor:
Jie Miao, Cong Wei, Hong-Lian Wang, Yu-Qing Li, Xin-Ming Yu, Xiu Yang, Hong-Wei Su, Ping Li, Li Wang
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e35728- (2024)
Renal fibrosis represents a pivotal characteristic of chronic kidney disease (CKD), for which effective interventions are currently lacking. The Src kinase activates the phosphatidylinositol-3 kinases (PI3K)/Akt1 pathway to promote renal fibrosis, ca
Externí odkaz:
https://doaj.org/article/76bada83e80842298ccf9d54d7ff0892
Autor:
Jian-Chun Li, Jian Jia, Li Dong, Zhong-Jing Hu, Xiao-Ru Huang, Hong-Lian Wang, Li Wang, Si-Jin Yang, Hui-Yao Lan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 180-190 (2023)
Transforming growth factor β (TGF-β)/Smad3 plays a vital role in hypertensive cardiac fibrosis. The long non-coding RNA (lncRNA) Erbb4-IR is a novel Smad3-dependent lncRNA that mediates kidney fibrosis. However, the role of Erbb4-IR in hypertensive
Externí odkaz:
https://doaj.org/article/b8d482a02bc7412dad9db09ac27457d3
Btg2 Promotes Focal Segmental Glomerulosclerosis via Smad3‐Dependent Podocyte‐Mesenchymal Transition
Autor:
Qiong‐ Dan Hu, Hong‐Lian Wang, Jian Liu, Tao He, Rui‐Zhi Tan, Qiong Zhang, Hong‐Wei Su, Fahsai Kantawong, Hui‐Yao Lan, Li Wang
Publikováno v:
Advanced Science, Vol 10, Iss 32, Pp n/a-n/a (2023)
Abstract Podocyte injury plays a critical role in the progression of focal segmental glomerulosclerosis (FSGS). Here, it is reported that B‐cell translocation gene 2 (Btg2) promotes Adriamycin (ADR)‐induced FSGS via Smad3‐dependent podocyte‐m
Externí odkaz:
https://doaj.org/article/e3572fd1bef84f3f8f69523790c0afb1
Autor:
Ze Peng, Huai-Ying Guo, Yu-Qing Li, Jian-Chun Li, Xiao-Hong Yang, Jian Liu, Qiong-Dan Hu, Hong-Lian Wang, Li Wang
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Renal fibrosis is a common feature of all types of chronic kidney disease (CKD) and is tightly regulated by the TGF-β/Smad3 pathway. Let-7i-5p belongs to the let-7 microRNA family with diverse biological functions. It has been reported that let-7i-5
Externí odkaz:
https://doaj.org/article/543485ab74a04449a00491826e8d56c1
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 373 (2022)
Beta (β) cell dysfunction or loss is the common pathological feature in all types of diabetes mellitus (diabetes). Resolving the underlying mechanism may facilitate the treatment of diabetes by preserving the β cell population and function. It is k
Externí odkaz:
https://doaj.org/article/2057af38bd50468889de751efc8a6c76
Autor:
Tie-Lin Chen, Hong-Lian Wang, Yun-Hong Liu, Yin Fang, Rui-Zhi Tan, Pu-Hui Zhou, Qin Zhou, Xiao-Yan Lv
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
Background. Ex vivo culture of intact embryonic kidney has become a powerful system for studying renal development. However, few methods have been available for gene manipulation and have impeded the identification and investigation of genes in this
Externí odkaz:
https://doaj.org/article/b4a2ea876c8e4a85a84e0ae42ef46381
Autor:
Rui-zhi Tan, Jian-chun Li, Bing-wen Zhu, Xiao-ru Huang, Hong-lian Wang, Jian Jia, Xia Zhong, Jian Liu, Li Wang, Hui-yao Lan
Publikováno v:
International Journal of Biological Sciences. 19:521-536
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c942e8c1ba1b137c9fba77db8cadecd8
https://doi.org/10.7150/ijbs.80200
https://doi.org/10.7150/ijbs.80200
Autor:
Li-Sha Ran, Ya-Zeng Wu, Yi-Wen Gan, Hong-Lian Wang, Li-Juan Wu, Chun-Mei Zheng, Yao Ming, Ran Xiong, Yong-Lin Li, Shi-Hang Lei, Xue Wang, Xiao-Qing Lao, Hong-Min Zhang, Li Wang, Chen Chen, Chang-Ying Zhao
Publikováno v:
Journal of Natural Medicines. 77:73-86
Abstract Excessive intrahepatocellular lipid accumulation or steatosis is caused by abnormal lipid metabolism and a common character of nonalcoholic fatty liver disease (NAFLD), which may progress into cirrhosis and hepatocellular cancer. Andrographo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebc739df5eb527220f4eb6b014b2d8c
https://doi.org/10.1007/s11418-022-01647-w
https://doi.org/10.1007/s11418-022-01647-w
Autor:
Jian Liu, Li Wang, Ronald Cw Ma, Ruizhi Tan, Biao Wei, Hong-Lian Wang, Xiao-Ru Huang, Huijun He, Xiao-Cui Chen, Si-Jin Yang, Jianchun Li, Hui-Yao Lan, Jingyi Sheng
Publikováno v:
Theranostics
Rationale: Poor β cell proliferation is one of the detrimental factors hindering islet cell replacement therapy for patients with diabetes. Smad3 is an important transcriptional factor of TGF-β signaling and has been shown to promote diabetes by in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c15aa940d668f7230a22177c12b8aa2
https://doi.org/10.7150/thno.67034
https://doi.org/10.7150/thno.67034