Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Hong-kun Wu"'
Autor:
Meng Fang, Hong-Kun Wu, Yumeng Pei, Yan Zhang, Xiangyu Gao, Yanyun He, Gengjia Chen, Fengxiang Lv, Peng Jiang, Yumei Li, Wenwen Li, Lin Wang, Jiafu Ji, Xinli Hu, Rui-Ping Xiao
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers. In particular, the dysregulation of ubiquitination-dependent
Externí odkaz:
https://doaj.org/article/e360a05504074936985e799da34289a5
Publikováno v:
Free Radical Biology and Medicine. 162:523-532
Mitochondrial permeability transition pore (mPTP) is an important regulator in cell apoptosis and necrosis. However, its role in hepatic steatosis, especially its electrophysiological properties transformation remains elusive. Herein, using diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70768df6279c43950a897a9d2cd56b6
https://doi.org/10.1016/j.freeradbiomed.2020.11.009
https://doi.org/10.1016/j.freeradbiomed.2020.11.009
Autor:
Si-si Pan, Feng Wang, Yong-peng Hui, Kai-yuan Chen, Liu Zhou, Wei-long Gao, Hong-kun Wu, Deng-sheng Zhang, Si-yuang Yang, Xuan-yi Hu, Gui-you Liang
Publikováno v:
Perfusion.
Background Previous studies proved that pyrin domain-containing protein 3 (NLRP3)-induced pyroptosis plays an important role in Myocardial ischemia-reperfusion injury (MIRI). Insulin can inhibit the activation of NLRP3 inflammasome, although the exac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7e36dd165e809808654b340657dda6
https://pubmed.ncbi.nlm.nih.gov/35506656
https://pubmed.ncbi.nlm.nih.gov/35506656
Autor:
Peng Xie, Rui-Ping Xiao, Fujian Wu, Chun-Mei Cao, Sile Guo, Fengxiang Lv, Yan Zhang, Feng Lan, Hong-Kun Wu, Mao Zhang, Li Jin, Xinli Hu, Dan Shan, Ying Song, Yimei Wang
Publikováno v:
Circulation. 142:1077-1091
Background: Ischemic heart disease is the leading cause of morbidity and mortality worldwide. Ischemic preconditioning (IPC) is the most powerful intrinsic protection against cardiac ischemia/reperfusion injury. Previous studies have shown that a mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::066be1ce0841309692dd4a5e66110600
https://doi.org/10.1161/circulationaha.119.044998
https://doi.org/10.1161/circulationaha.119.044998
Publikováno v:
Aging (Albany NY)
Recently, homologous pleckstrin-homology (PH)-domain leucine-rich-repeat protein phosphatases (PHLPP2) has been reported as a tumor suppressor in colon cancer. This study aimed to unravel the possible involvement of long noncoding RNAs (lncRNAs) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896d4b990964410d3f9979f34dee873f
https://doi.org/10.18632/aging.103246
https://doi.org/10.18632/aging.103246
Autor:
Yuan Yao, Dao Wen Wang, Jiaojiao Guo, Yanyun He, Ruisheng Song, Gengjia Chen, Jin Huang, Meng Fang, Shuo Zhang, Hong-Kun Wu, Rui-Ping Xiao, Zhuan Zhou, Peng Jiang, Xinli Hu, Dan Shan, Li Jin, Wei Peng, Chun-Mei Cao, Fengxiang Lv, Fenghua Liu, Yan Zhang, Lifei Tang
Publikováno v:
Circulation. 139:901-914
Background: Mitsugumin 53 (MG53 or TRIM72), a striated muscle-specific E3 ligase, promotes ubiquitin-dependent degradation of the insulin receptor and insulin receptor substrate-1 and subsequently induces insulin resistance, resulting in metabolic sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fad1bb887712d144d080fa6f8e3cf36
https://doi.org/10.1161/circulationaha.118.037216
https://doi.org/10.1161/circulationaha.118.037216
Autor:
Han Feng, Shuo Zhang, Xinli Hu, Gengjia Chen, Hong-Kun Wu, Rui-Ping Xiao, Matthew J Robeson, Hao Shen, Fengxiang Lv, Yan Zhang
Publikováno v:
Circulation. 142
Introduction: MG53, essential for cardiac ischemic protection, negatively regulates insulin receptor (IR) to trigger globular metabolic dysfunction, which makes up a big obstacle for its clinical use. In vitro evidence shows that C14A site of MG53 mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9302a0623ed92024bee1410db4c60ecb
https://doi.org/10.1161/circ.142.suppl_3.14197
https://doi.org/10.1161/circ.142.suppl_3.14197
Autor:
Run‑He Liu, Dan Liang, Qi‑Si Lian, Ke‑Jing Wang, Fulei Zeng, Miao‑Ying Cheng, Hong‑Kun Wu, Zhi‑Qun Tang
Publikováno v:
Molecular Medicine Reports
Smoking is a risk factor associated with bone and oral diseases, particularly periodontitis. Nicotine, the major toxic component of tobacco, is able to affect the quality and quantity of bone. Osteoblasts serve an important role in bone formation. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0467e314b6074d69084ac6f10225633
http://europepmc.org/articles/PMC5984003
http://europepmc.org/articles/PMC5984003
Publikováno v:
Cancer Biomarkers. 2017, Vol. 20 Issue 2, p191-198. 8p.
Publikováno v:
Molecular Pharmacology. 92:211-218
MG53 (also known as tripartite motif, TRIM72) is a cardiac and skeletal muscle-specific TRIM-family protein that exhibits multiple biologic functions. First, MG53 participates in plasma membrane repair of the heart, skeletal muscle, and, other tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d906b57b876ad0c515d121cfd2f4bd
https://doi.org/10.1124/mol.117.108241
https://doi.org/10.1124/mol.117.108241