Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Hong-hong Zhang"'
Publikováno v:
Zhongguo quanke yixue, Vol 27, Iss 24, Pp 2982-2986 (2024)
Background Geriatric depression is a severe mental illness distinct from depression in other age groups, characterized by significant heterogeneity. Subclinical hypothyroidism (SCH) is a state of hypothyroidism with subtle clinical signs. The impact
Externí odkaz:
https://doaj.org/article/6c209b1d4c9147e9bb76824bec007933
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Diabetes mellitus (DM) is a fast-growing chronic metabolic disorder that leads to significant health, social, and economic problems worldwide. Chronic hyperglycemia caused by DM leads to multiple devastating complications, including macrovascular com
Externí odkaz:
https://doaj.org/article/5680b74062c7482a81d0acf863d3b67e
Autor:
Hong-Hong Zhang, Xiao-Jing Du, Mei-Ling Deng, Lie Zheng, Dun-Chen Yao, Zhi-Qiang Wang, Qun-Ying Yang, Shao-Xiong Wu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Purpose: The recurrent/progressive glioblastoma multiforme (GBM) carries a dismal prognosis and the definitive treatment strategy has not yet been established. This study aimed to assess the efficacy and safety of apatinib in recurrent/progressive GB
Externí odkaz:
https://doaj.org/article/39caa135a9d24098a43c03e4e09b8aed
Autor:
Kai Zheng, Fan Hu, Yang Zhou, Juan Zhang, Jie Zheng, Chuan Lai, Wan Xiong, Ke Cui, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Guo Chen, Heng-Ye Man, Dan Liu, Youming Lu, Ling-Qiang Zhu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Several micro RNAs have been shown to be deregulated in brain tissue or sera from individuals with Alzheimer’s disease and in AD mouse models. The authors show that miR-135a-5p is downregulated in excitatory pyramidal neurons from AD mice and that
Externí odkaz:
https://doaj.org/article/3366a3bed29948729d65876a46ebc7a7
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
AimTo explore the relationship between genomic DNA methylation and diabetic chronic complications.Methods299 patients with type 2 diabetes mellitus (T2DM) hospitalized in the Second Affiliated Hospital of Soochow University were enrolled. We divided
Externí odkaz:
https://doaj.org/article/e7ebf3fd0efe4766b554e2eeb68e75c4
Autor:
Yuan⁃yuan WANG, Ming⁃wei ZHU, Lu⁃ning WANG, Hong⁃hong ZHANG, Ya⁃zhuo HU, Zhi⁃tao HAN, Ying⁃han ZHANG
Publikováno v:
Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 19, Iss 8, Pp 573-580 (2019)
Objective To evaluate the expression of P62 protein in the characteristic pathological changes of common neurodegenerative diseases and to explore its significance in pathological diagnosis. Methods Eleven cases of neurodegenerative diseases and 3 no
Externí odkaz:
https://doaj.org/article/aa64dea8a59d4074b89f813cead7587e
Autor:
Ji Hu, Xin Qin, Zhen-Yuan Song, Pan-Pan Yang, Yu Feng, Qian Sun, Guang-Yin Xu, Hong-Hong Zhang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract The present study was designed to investigate the roles of P2X3 receptors in dorsal root ganglion (DRG) neurons in colonic hypersensitivity and the effects of alpha-lipoic acid (ALA) on P2X3 receptor activity and colonic hypersensitivity of
Externí odkaz:
https://doaj.org/article/14fef88fc81a4d6b805017c819fa9003
Autor:
Lan-Ting Zhou, Dan Liu, Hui-Cong Kang, Lu Lu, He-Zhou Huang, Wen-Qing Ai, Yang Zhou, Man-Fei Deng, Hao Li, Zhi-Qiang Liu, Wei-Feng Zhang, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Jun Jia, Avijite Kumer Sarkar, Saldin Sharaydeh, Jie Wang, Heng-Ye Man, Marcel Schilling, Lars Bertram, Youming Lu, Ziyuan Guo, Ling-Qiang Zhu
Publikováno v:
Science Advances. 9
The neuron-glia cross-talk is critical to brain homeostasis and is particularly affected by neurodegenerative diseases. How neurons manipulate the neuron-astrocyte interaction under pathological conditions, such as hyperphosphorylated tau, a patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac23785ce36d9410b06d65db463b3ad7
https://doi.org/10.1126/sciadv.abq7105
https://doi.org/10.1126/sciadv.abq7105
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
Aim. DNA methylation is thought to be involved in regulating the expression of key genes and inducing diabetic peripheral neuropathy (DPN). However, clinically, the level of whole-genome DNA methylation and its relationship with DPN remains unclear.
Externí odkaz:
https://doaj.org/article/ba30cb91c731462ca2b6fdf59dfbc82a
Publikováno v:
Neural Regeneration Research, Vol 11, Iss 7, Pp 1165-1171 (2016)
We previously performed transcriptome sequencing and found that genes for matrix metalloproteinases (MMPs), such as MMP7 and 12, seem to be highly upregulated following peripheral nerve injury, and may be involved in nerve repair. In the present stud
Externí odkaz:
https://doaj.org/article/be83500782d947a7acb16b740f3ecaa9