Huangkui capsule alleviates renal tubular epithelial–mesenchymal transition in diabetic nephropathy via inhibiting NLRP3 inflammasome activation and TLR4/NF-κB signaling

Autor: Yi-Gang Wan, Yan Long, Zi-Yue Wan, Yue Tu, Qian Ma, Ren-Mao Tang, Lu Huang, Wei Wu, Wen-Wen Wang, Wen-Bei Han, Hong-Yun Yee, Hai-Tao Tang, Ying-Lu Liu

Publikováno v: Phytomedicine. 57:203-214

Background Huangkui capsule (HKC), an anti-inflammatory Chinese modern patent medicine, has been now widely applied to the clinical therapy of diabetic nephropathy (DN). However, the overall therapeutic mechanisms in vivo are still unclear. Renal tub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b033c42431d0f0f6d794f6137d0681
https://doi.org/10.1016/j.phymed.2018.12.021

[Multi-targeted therapeutic effects of Huangkui Capsules on insulin resistance and urine microalbumin in early diabetic kidney disease patients]

Autor: Wei, Wu, Ying-Lu, Liu, Yi-Gang, Wan, Dong-Wei, Cao, Qi-Jun, Fang, Yue, Tu, Bu-Hui, Liu, Wen-Wen, Wang, Mei-Zi, Wang, Hong-Yun, Yee, Can-Can, Yuan, Wei, Hu

Publikováno v: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 45(23)

To observe the multi-targeted therapeutic effects of Huangkui Capsules(HKC)on insulin resistance(IR)and urine microalbumin in the early diabetic kidney disease(DKD)patients. The case data from the 83 DKD patients at G2 and A2 stage were collected res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::323b619fdd389fbb9cc4a8bcb581d3d3
https://pubmed.ncbi.nlm.nih.gov/33496121

[Triptolide inhibits NLRP3 inflammasome activation and ameliorates podocyte epithelial-mesenchymal transition induced by high glucose]

Autor: Wei, Wu, Bu-Hui, Liu, Yi-Gang, Wan, Wei, Sun, Ying-Lu, Liu, Wen-Wen, Wang, Qi-Jun, Fang, Yue, Tu, Hong-Yun, Yee, Can-Can, Yuan, Zi-Yue, Wan

Publikováno v: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 44(24)

The aim of this paper was to explore the effects of triptolide( TP),the effective component of Tripterygium wilfordii on improving podocyte epithelial-mesenchymal transition( EMT) induced by high glucose( HG),based on the regulative mechanisms of Nod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b4971afc3d1fe7848af7c723845c16a4
https://pubmed.ncbi.nlm.nih.gov/32237395

[Molecular mechanisms of non-coding RNA regulating autophagy and interventional effects of Chinese herbal medicine]

Autor: Yue, Tu, Yi-Gang, Wan, Yi-Huang, Gu, Bu-Hui, Liu, Ying-Lu, Liu, Wen-Wen, Wang, Qi-Jun, Fang, Hong-Yun, Yee, Wei, Wu, Zi-Yue, Wan

Publikováno v: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 44(21)

Long non-coding RNAs(lncRNAs) and microRNAs(miRNAs),as members of the non-coding RNA family,play important roles in upstream processes that regulate autophagy in mammalian cells. LncRNA and miRNA participate in various phases of the process of autoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d9a6b7d12309d006b4c0ce462fe3cf7
https://pubmed.ncbi.nlm.nih.gov/31872646

[Molecular regulatory mechanisms of hypoxia-inducible factor and interventional effect of Chinese herbal medicine].

Autor: Bu-Hui L; Nephrology Division,Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029,China Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Mei-Zi W; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Wei S; Nephrology Division,Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029,China., Yi-Gang W; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School Nanjing 210008,China., Wei WU; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School Nanjing 210008,China., Qi-Jun F; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Wen-Wen W; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Hong-Yun Y; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Can-Can Y; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Ying-Lu L; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School Nanjing 210008,China., Yue TU; Department of Traditional Chinese Medicine Health Preservation,Acupuncture and Moxibustion and Massage College·Health Preservation and Rehabilitation College,Nanjing University of Chinese Medicine Nanjing 210023,China., Fee-Lan C; The School of Pharmacy,Management and Science University Shah Alam 40100,Malaysia.

Publikováno v: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2020 Oct; Vol. 45 (20), pp. 4805-4811.