Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Hong-Yi Zhao"'
Publikováno v:
Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 19, Iss 8, Pp 552-558 (2019)
Objective To investigate the mechanism of the effect of melatonin (MT) on permeability of blood-brainbarrier (BBB) in chronic cerebral hypoperfusion (CCH) rats. Methods Therat model of CCH was established by bilateral common carotid artery occlusion
Externí odkaz:
https://doaj.org/article/cdd6349ab8624823ad651e05a9bbbf24
Autor:
Yong⁃hua HUANG, Hong⁃yi ZHAO
Publikováno v:
Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 19, Iss 7, Pp 461-465 (2019)
Cerebral small vessel disease (cSVD) has been reported for more than a century. Owing to the aging of population becoming more and more prominent, cSVD, which tends to occur in the elderly,is becoming the focus of both basic and clinical research. Wi
Externí odkaz:
https://doaj.org/article/f31ba12893d9492ebc4bcadadd32ad51
Publikováno v:
Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 19, Iss 7, Pp 481-489 (2019)
Objective To observe the protective function and mechanism of melatonin(MT)against white matter lesions in corpus callosum induced by chronic cerebral hypoperfusion (CCH) in cerebral small vessel disease (cSVD) rats. Methods Forty⁃four adult male S
Externí odkaz:
https://doaj.org/article/db43c88a63194e55af300c3ffe32c804
Publikováno v:
Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 19, Iss 4, Pp 281-285 (2019)
Cerebral small vessel disease (cSVD) is the leading cause of chronic cerebral hypoperfusion. Gait, balance disorders and falls associated with white matter lesions can increase the risk of sickness and death in patients with cSVD. Therefore, understa
Externí odkaz:
https://doaj.org/article/dca7938b14bd41a388dd982d7fedd42f
Autor:
Minhang Xin, Weiming Duan, Yifan Feng, Yuan-Yuan Hei, Hao Zhang, Ying Shen, Hong-Yi Zhao, Shuai Mao, San-Qi Zhang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 651-656 (2018)
Phosphoinositide 3-kinase Delta (PI3Kδ) plays a key role in B-cell signal transduction and inhibition of PI3Kδ was confirmed to have clinical benefit in certain types of activation of B-cell malignancies. Herein, we reported a novel series of 4-pyr
Externí odkaz:
https://doaj.org/article/a6de2c5a67fe4ee1805a686eb1048be3
Autor:
Hong-Yi Zhao, Shu-Di Zhang, Kai Zhang, Xi Wang, Qing-Yan Zhao, Shu-Juan Zhang, Zi-Xuan Dai, Yong-Sheng Qian, You-Jing Zhang, Hao-Tian Wei, Yan-Hong Tang, Cong-Xin Huang
Publikováno v:
Chinese Medical Journal, Vol 130, Iss 2, Pp 171-178 (2017)
Background: Shensong Yangxin (SSYX), a traditional Chinese herbal medicine, has long been used clinically to treat arrhythmias in China. However, the mechanism of SSYX on atrial fibrillation (AF) is unknown. In this study, we tested the hypothesis th
Externí odkaz:
https://doaj.org/article/ad9294dcde2f4ab2a5dee716bf437905
Publikováno v:
Journal of Marine Science and Engineering, Vol 9, Iss 2, p 167 (2021)
This paper presents a simple but workable constitutive model for the stress–strain relationship of sandy soil during the process of tunneling construction disturbance in coastal cities. The model was developed by linking the parameter K and interna
Externí odkaz:
https://doaj.org/article/a3c58029bb1a4f5d929164a3dde0e602
Publikováno v:
Journal of Marine Science and Engineering, Vol 7, Iss 6, p 165 (2019)
This study aims to develop a simple but effective approach to investigate the stability of an unsaturated and multilayered coastal-embankment slope during the rainfall, in which a Random Search Algorithm (RSA) based on the random sampling idea of the
Externí odkaz:
https://doaj.org/article/9c8ad14593d144cd8ac88199674b2b99
Publikováno v:
Drug development researchREFERENCES.
Recent years have witnessed the rapid development of targeted protein degradation (TPD), especially proteolysis targeting chimeras. These degraders have manifested many advantages over small molecule inhibitors. To date, a huge number of degraders ha