Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Hong-Sheng Lee"'
1
Akademický článek
Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex
Autor: Hung-Sheng Hua, Heng-Ching Wen, Hong-Sheng Lee, Chih-Ming Weng, Fara Silvia Yuliani, Han-Pin Kuo, Bing-Chang Chen, Chien-Huang Lin
Publikováno v: Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-16 (2023)
Abstract Background Reduction of histone deacetylase (HDAC) 2 expression and activity may contribute to amplified inflammation in patients with severe asthma. Connective tissue growth factor (CTGF) is a key mediator of airway fibrosis in severe asthm
Externí odkaz: https://doaj.org/article/475d32a6bb5c407d9449d3a80d54e245
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2
Akademický článek
Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation
Autor: Hung-Sheng Hua, Heng-Ching Wen, Chih-Ming Weng, Hong-Sheng Lee, Bing-Chang Chen, Chien-Huang Lin
Publikováno v: Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-12 (2021)
Abstract Background Histone deacetylase (HDAC) inhibition was reported to ameliorate lung fibrosis in animal models. However, little is known about the underlying mechanism of HDAC7 in the regulation of CTGF production in lung fibroblasts. Methods Th
Externí odkaz: https://doaj.org/article/8dc91521816a47bb91d69da63c01f231
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3
Akademický článek
A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model
Autor: Lu-Yang Yeh, Yu-Ting Fang, Hong-Sheng Lee, Chia-Hao Liu, You-Yin Chen, Yu-Chun Lo, Vincent Laiman, Jing-Ping Liou, Kian Fan Chung, Hsiao-Chi Chuang, Chien-Huang Lin
Publikováno v: Frontiers in Medicine, Vol 9 (2022)
BackgroundChronic obstructive pulmonary disease (COPD) is a major cause of chronic mortality. The objective of this study was to investigate the therapeutic potential of a novel potent histone deacetylase (HDAC) inhibitor MPT0E028 on emphysema.Materi
Externí odkaz: https://doaj.org/article/f98a16b2bf54476ca57c2e8c7b2c579b
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4
GPS CONTINUOUSLY OPERATING REFERENCE STATION (CORS) SELECTION TOWARDS REGIONAL GPS ORBIT DETERMINATION: A SIMULATED STUDY USING TRILATERATION TECHNIQUE
Autor: Hong Sheng Lee, Wan Anom Wan Aris, Tajul Ariffin Musa, Ahmad Zuri Sha'ameri, Wei Han Ooi, Anuar Ahmad, Mohammad Asrul Mustafar
Publikováno v: Jurnal Teknologi. 85:99-105
Global Positioning System (GPS) orbital error can be minimized using precise satellite orbit. These precise satellite orbits are calculated using GPS measurements from ground CORS. The distribution of the CORS involved in GPS satellite orbit determin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47476b6ab62d0886b7121f027c788c67
https://doi.org/10.11113/jurnalteknologi.v85.18541
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5
Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation
Autor: Chien-Huang Lin, Hung Sheng Hua, Hong Sheng Lee, Bing Chang Chen, Chih Ming Weng, Heng Ching Wen
Publikováno v: Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-12 (2021)
Background Histone deacetylase (HDAC) inhibition was reported to ameliorate lung fibrosis in animal models. However, little is known about the underlying mechanism of HDAC7 in the regulation of CTGF production in lung fibroblasts. Methods The role of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684000fed93841d0ebdeecbbd81b547a
http://europepmc.org/articles/PMC8135160
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6
Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors
Autor: Hong-Sheng Lee, Chien-Huang Lin, Kai-Cheng Hsu, Ling-Wei Hsin, Huang Wei-Jan, Hui-Ju Tseng, Andrew H.-J. Wang, Hao-Ching Wang, Tony Eight Lin, Chia I. Liu, Jung-Chun Chu
Publikováno v: European journal of medicinal chemistry. 219
The pathogenesis of Alzheimer’s disease (AD) has been associated with dysregulation of histone deacetylases (HDACs). Previously, acridine-based HDAC inhibitors have shown potential in ameliorating HDAC activity and enhancing neurite outgrowth. In t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cf0989840cf882cedbc42e8d04a86d
https://pubmed.ncbi.nlm.nih.gov/33845233
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7
Mycobacterium tuberculosis induces connective tissue growth factor expression through the TLR2-JNK–AP-1 pathway in human lung fibroblasts
Autor: Ming Chih Yu, Bing Chang Chen, Hung Sheng Hua, Hong Sheng Lee, Cheng Hui Wang, Chien-Huang Lin
Publikováno v: FASEB J
Mycobacterium tuberculosis (M.tb) infection in lung causes pulmonary fibrosis, which leads to the irreversible reduction of pulmonary function. Fibrotic protein connective tissue growth factor (CTGF) expression has been confirmed to play a crucial ro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568f8688c68c4cbc16051d2d179a0685
https://europepmc.org/articles/PMC6902670/
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10
Tympanostomy tubes: Use and problems
Autor: Hong-Sheng Lee, Cheng-Shun Lee
Publikováno v: Operative Techniques in Otolaryngology-Head and Neck Surgery. 7:9-15
Since the increased incidence of otitis media with effusions reported in the medical literature, methods of treatment are of great concern for pediatricians and otolaryngologists. Tympanostomy with tube insertion is indicated in cases with persistent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::240d3417c90cf4b00a204b8c8a41bdba
https://doi.org/10.1016/s1043-1810(96)80055-8
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