Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Hong-Ping Guan"'
Autor:
Hong-Ping Guan, Yusheng Xiong
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
GPR40 is a class A G-protein coupled receptor (GPCR) mainly expressed in pancreas, intestine, and brain. Its endogenous ligand is long-chain fatty acids, which activate GPR40 after meal ingestion to induce secretion of incretins in the gut, including
Externí odkaz:
https://doaj.org/article/78eaa0dd239d4160a57dbfdcc9ae0e0a
Autor:
Eric S Muise, Hong-Ping Guan, Jinqi Liu, Andrea R Nawrocki, Xiaodong Yang, Chuanlin Wang, Carlos G Rodríguez, Dan Zhou, Judith N Gorski, Marc M Kurtz, Danqing Feng, Kenneth J Leavitt, Lan Wei, Robert R Wilkening, James M Apgar, Shiyao Xu, Ku Lu, Wen Feng, Ying Li, Huaibing He, Stephen F Previs, Xiaolan Shen, Margaret van Heek, Sandra C Souza, Mark J Rosenbach, Tesfaye Biftu, Mark D Erion, David E Kelley, Daniel M Kemp, Robert W Myers, Iyassu K Sebhat
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211568 (2019)
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs. There is interest in discovering a pharmacologic exercise m
Externí odkaz:
https://doaj.org/article/f28b2c263a184739b47d79a0d7b9272a
Autor:
Hong-Ping Guan, Xiaodong Yang, Ku Lu, Sheng-Ping Wang, Jose M. Castro-Perez, Stephen Previs, Michael Wright, Vinit Shah, Kithsiri Herath, Dan Xie, Daphne Szeto, Gail Forrest, Jing Chen Xiao, Oksana Palyha, Li-Ping Sun, Paula J. Andryuk, Samuel S. Engel, Yusheng Xiong, Songnian Lin, David E. Kelley, Mark D. Erion, Harry R. Davis, Liangsu Wang
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2183-2195 (2015)
Glucagon and insulin have opposing action in governing glucose homeostasis. In type 2 diabetes mellitus (T2DM), plasma glucagon is characteristically elevated, contributing to increased gluconeogenesis and hyperglycemia. Therefore, glucagon receptor
Externí odkaz:
https://doaj.org/article/2172e3fff908429b99f72a94d0b8f239
Autor:
Sheo B Singh, Ling Kang, Andrea R Nawrocki, Dan Zhou, Margaret Wu, Stephen Previs, Corey Miller, Haiying Liu, Catherine D G Hines, Maria Madeira, Jin Cao, Kithsiri Herath, Larry D Spears, Clay F Semenkovich, Liangsu Wang, David E Kelley, Cai Li, Hong-Ping Guan
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170721 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0164133.].
Externí odkaz:
https://doaj.org/article/a0c42ee3102d4affbbde67b225f02f09
Autor:
Seongah Han, Taro E. Akiyama, Stephen F. Previs, Kithsiri Herath, Thomas P. Roddy, Kristian K. Jensen, Hong-Ping Guan, Beth A. Murphy, Lesley A. McNamara, Xun Shen, Walter Strapps, Brian K. Hubbard, Shirly Pinto, Cai Li, Jing Li
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2615-2622 (2013)
Hepatic glucose overproduction is a major characteristic of type 2 diabetes. Because glucagon is a key regulator for glucose homeostasis, antagonizing the glucagon receptor (GCGR) is a possible therapeutic strategy for the treatment of diabetes melli
Externí odkaz:
https://doaj.org/article/1d1d5798fd99409895b2d79ffd6971d0
Autor:
Sheo B Singh, Ling Kang, Andrea R Nawrocki, Dan Zhou, Margaret Wu, Stephen Previs, Corey Miller, Haiying Liu, Catherine D G Hines, Maria Madeira, Jin Cao, Kithsiri Herath, Larry D Spears, Clay F Semenkovich, Liangsu Wang, David E Kelley, Cai Li, Hong-Ping Guan
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164133 (2016)
Platensimycin (PTM) is a natural antibiotic produced by Streptomyces platensis that selectively inhibits bacterial and mammalian fatty acid synthase (FAS) without affecting synthesis of other lipids. Recently, we reported that oral administration of
Externí odkaz:
https://doaj.org/article/09d9a7eab4db484ba8f12a3152bad96d
Autor:
Faridoddin Mirshahi, Sophie C. Cazanave, Prasanna K. Santhekadur, Bubu A. Banini, Divya P. Kumar, Abdul M. Oseini, Hae Ki Min, Liangsu Wang, Pierre Bedossa, Mulugeta Seneshaw, Cristina Alonso, Hong Ping Guan, Srinivas V. Koduru, Arun J. Sanyal
Publikováno v:
Hepatology. 73:1290-1306
BACKGROUND AND AIMS The mechanisms by which the I148M mutant variant of the patatin-like phospholipase domain-containing 3 (PNPLA3I148M ) drives development of nonalcoholic steatohepatitis (NASH) are not known. The aim of this study was to obtain ins
Autor:
F. Anthony Romero, Robert W. Myers, Hong-Ping Guan, Anantha Gollapudi, Gaochao Zhou, Ku Lu, James F. Dropinski, Marc M. Kurtz, Xiaodong Yang, Cai Li, Iyassu K. Sebhat, Tesfaye Biftu, Danqing Feng, Ahmet Kekec, Ann E. Weber, Qing Shao, Daniel M. Kemp, Andrew Kassick, Shiyao Xu, Maria E. Trujillo
Publikováno v:
ACS Medicinal Chemistry Letters. 9:39-44
5'-Adenosine monophosphate-activated protein kinase (AMPK) is a key regulator of mammalian energy homeostasis and has been implicated in mediating many of the beneficial effects of exercise and weight loss including lipid and glucose trafficking. As
Autor:
Myers, Robert W.1 robertwmyersphd@gmail.com, Hong-Ping Guan2, Ehrhart, Juliann3, Petrov, Aleksandr2, Prahalada, Srinivasa3, Tozzo, Effie2, Xiaodong Yang2, Kurtz, Marc M.1, Trujillo, Maria4, Gonzalez Trotter, Dinko5, Danqing Feng6, Shiyao Xu7, Eiermann, George4, Holahan, Marie A.5, Rubins, Daniel5, Conarello, Stacey4, Xiaoda Niu1, Souza, Sandra C.2, Miller, Corin5, Jinqi Liu2
Publikováno v:
Science. 8/4/2017, Vol. 357 Issue 6350, p507-511. 5p. 5 Graphs.
Autor:
Hong-Ping Guan, Wen Feng, Daniel M. Kemp, Judith N. Gorski, Shiyao Xu, Ying Li, Dan Zhou, Ku Lu, Tesfaye Biftu, David E. Kelley, Chuanlin Wang, Sandra C. Souza, Lan Wei, Danqing Feng, Robert R. Wilkening, Andrea R. Nawrocki, Iyassu K. Sebhat, Mark J. Rosenbach, Margaret van Heek, Carlos G. Rodriguez, Eric S. Muise, Xiaodong Yang, Mark D. Erion, Jinqi Liu, Stephen F. Previs, James M. Apgar, Marc M. Kurtz, Huaibing He, Robert W. Myers, Xiaolan Shen, Kenneth J. Leavitt
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211568 (2019)
PLoS ONE
PLoS ONE
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs. There is interest in discovering a pharmacologic exercise m