Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hong-Liang Bao"'
Publikováno v:
Molecules, Vol 23, Iss 10, p 2572 (2018)
In contrast to Z-DNA that was stabilized and well-studied for its structure by chemical approaches, the stabilization and structural study of Z-RNA remains a challenge. In this study, we developed a Z-form RNA stabilizer m8Gm, and demonstrated that i
Externí odkaz:
https://doaj.org/article/1982a53347d0447cb125d3ed721a64d2
Autor:
Hong-Liang Bao, Yan Xu
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630839
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b348866320e8ef5a5d76ae2c1da4ce1
https://doi.org/10.1007/978-1-0716-3084-6_8
https://doi.org/10.1007/978-1-0716-3084-6_8
Autor:
Koyuki Fukumoto, Soyoung Park, Ji Hye Yum, Takumi Ishizuka, Hong-Liang Bao, Yan Xu, Hiroshi Sugiyama, Daisuke Hori
Publikováno v:
ACS Biomaterials Science & Engineering. 7(4):1338-1343
Chemical modifications of innate DNA/RNA aptamers facilitate the improvement of their function. Herein, we report our modular strategy to manipulate a thrombin-binding DNA aptamer (TBA) to improve its anticoagulation activity and binding affinity. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b89ef7047b037fd528f44fad78751a
http://hdl.handle.net/2433/268790
http://hdl.handle.net/2433/268790
Publikováno v:
Journal of Medicinal Chemistry. 64:711-718
In this study, we incorporated 8-trifluoromethyl-2'-deoxyguanosine (FG) into a thrombin binding aptamer (TBA). Circular dichroism, nuclear magnetic resonance (NMR), electrophoresis, and prothrombin time (PT) assay were performed to investigate the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cebbd133af3a20605862a278ee61d08
https://doi.org/10.1021/acs.jmedchem.0c01711
https://doi.org/10.1021/acs.jmedchem.0c01711
Autor:
Takumi Ishizuka, Yue Ma, Masayuki Tera, Kazuo Nagasawa, Shogo Sasaki, Yan Xu, Takatsugu Hirokawa, Hong-Liang Bao
Publikováno v:
RSC Advances. 10:43319-43323
G-quadruplex structures (G4s) in guanine-rich regions of DNA play critical roles in various biological phenomena, including replication, translation, and gene expression. There are three types of G4 topology, i.e., parallel, anti-parallel, and hybrid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8eb68c08932e395fddb13cac459c80
https://doi.org/10.1039/d0ra09413g
https://doi.org/10.1039/d0ra09413g
Autor:
Yan Xu, Hong-Liang Bao
Publikováno v:
Current Protocols. 1
This article contains detailed synthetic protocols for the preparation of DNA oligonucleotides containing 8-trifluoromethyl-2'-deoxyguanosine (CF3 dG) and their application to observe Z-DNA structure in vitro and in living HeLa cells. First, using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cf44e255c6de6151c0919918544fc53
https://doi.org/10.1002/cpz1.28
https://doi.org/10.1002/cpz1.28
Publikováno v:
Nucleic Acids Research
Z-DNA is known to be a left-handed alternative form of DNA and has important biological roles as well as being related to cancer and other genetic diseases. It is therefore important to investigate Z-DNA structure and related biological events in liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd69cf72bbe76ea2e5cab08206830c5
https://doi.org/10.1093/nar/gkaa505
https://doi.org/10.1093/nar/gkaa505
Autor:
Yan Xu, Hong-Liang Bao
Publikováno v:
Chemical communications (Cambridge, England). 56(48)
In the present study, we employed a 19F NMR approach to study the association of telomere RNA and DNA in vitro and in living human cells. We successfully characterized the DNA-RNA hybrid G-quadruplex (HQ) structure formed by telomeric DNA and RNA. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030aff581ceb9b41d20bfccfe71adfbd
https://pubmed.ncbi.nlm.nih.gov/32396161
https://pubmed.ncbi.nlm.nih.gov/32396161
Autor:
Hong-Liang Bao, Yan Xu
Publikováno v:
Nature Protocols. 13:652-665
Growing evidence indicates that RNA G-quadruplexes have important roles in various processes such as transcription, translation, regulation of telomere length, and formation of telomeric heterochromatin. Investigation of RNA G-quadruplex structures a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0aaccf98500546cdc96d8a6bb2850165
https://doi.org/10.1038/nprot.2017.156
https://doi.org/10.1038/nprot.2017.156
Autor:
Fuqiang Huang, Xin Wang, Qingyuan Bi, Feng Gu, Hong-Liang Bao, Jianjun Liu, Guoheng Yin, Xian-Long Du
Publikováno v:
ChemSusChem. 10:3044-3048
The chemical transformation of CO2 is an efficient approach in low-carbon energy system. The development of nonprecious metal catalysts with sufficient activity, selectivity, and stability for the generation of CO by CO2 reduction under mild conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da6b98c151bd0a7ea2c140b36024ad8c
https://doi.org/10.1002/cssc.201700787
https://doi.org/10.1002/cssc.201700787