Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Hong-Kai Lee"'
1
Akademický článek
Unsupervised spatially embedded deep representation of spatial transcriptomics
Autor: Hang Xu, Huazhu Fu, Yahui Long, Kok Siong Ang, Raman Sethi, Kelvin Chong, Mengwei Li, Rom Uddamvathanak, Hong Kai Lee, Jingjing Ling, Ao Chen, Ling Shao, Longqi Liu, Jinmiao Chen
Publikováno v: Genome Medicine, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Optimal integration of transcriptomics data and associated spatial information is essential towards fully exploiting spatial transcriptomics to dissect tissue heterogeneity and map out inter-cellular communications. We present SEDR, which us
Externí odkaz: https://doaj.org/article/a8125adae2f14b7d8fa5d78ddce5cfbd
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2
Akademický článek
Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore
Autor: Fransiskus X. Ivan, Xinrui Zhou, Suk Hiang Lau, Shamima Rashid, Jasmine S.M. Teo, Hong Kai Lee, Evelyn S. Koay, Kwai Peng Chan, Yee Sin Leo, Mark I.C. Chen, Chee Keong Kwoh, Vincent T. Chow
Publikováno v: International Journal of Infectious Diseases, Vol 90, Iss , Pp 84-96 (2020)
Background: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular evolution and receptor-binding specificit
Externí odkaz: https://doaj.org/article/3306aba6cf884746a7e37e1c14eafa98
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3
Akademický článek
Cost-benefit analysis of introducing next-generation sequencing (metagenomic) pathogen testing in the setting of pyrexia of unknown origin.
Autor: Jia Hui Chai, Chun Kiat Lee, Hong Kai Lee, Nicholas Wong, Kahwee Teo, Chuen Seng Tan, Praveen Thokala, Julian Wei-Tze Tang, Paul Anantharajah Tambyah, Vernon Min Sen Oh, Tze Ping Loh, Joanne Yoong
Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0194648 (2018)
Pyrexia of unknown origin (PUO) is defined as a temperature of >38.3°C that lasts for >3 weeks, where no cause can be found despite appropriate investigation. Existing protocols for the work-up of PUO can be extensive and costly, motivating the appl
Externí odkaz: https://doaj.org/article/ad8c1bcde3824f2294c1fd9a4cf6e0d2
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5
Akademický článek
Molecular Evidence of Transmission of Influenza A/H1N1 2009 on a University Campus.
Autor: Ramandeep Kaur Virk, Vithiagaran Gunalan, Hong Kai Lee, Masafumi Inoue, Catherine Chua, Boon-Huan Tan, Paul Anantharajah Tambyah
Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0168596 (2017)
In the recent years, the data on the molecular epidemiology of influenza viruses have expanded enormously because of the availability of cutting-edge sequencing technologies. However, much of the information is from the temperate regions with few stu
Externí odkaz: https://doaj.org/article/d86f21f75abe49f9be5d7709a086d8f7
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6
Akademický článek
Molecular epidemiology of rhinovirus among hospitalised patients, Singapore
Autor: Chun Kiat Lee, Erik Wei Jun Low, Christian Benjamin George Highfield, Hong Kai Lee, Paul Tambyah Anantharajah, Tze Ping Loh, Evelyn Siew-Chuan Koay
Publikováno v: Microbiologia Medica, Vol 31, Iss 4 (2016)
Human rhinovirus (HRV) is the most prevalent respiratory etiological agent in the world. Over 100 genotypes have been characterised using molecular genotyping techniques. Here, we characterised the molecular epidemiology of the circulating rhinovirus
Externí odkaz: https://doaj.org/article/f675d46b870f4cb0831101fb36d9ca91
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7
Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore
Autor: Evelyn Siew-Chuan Koay, Vincent T. K. Chow, Shamima Rashid, Fransiskus Xaverius Ivan, Jasmine S. M. Teo, Kwai Peng Chan, Suk Hiang Lau, Chee Keong Kwoh, Mark I-Cheng Chen, Yee Sin Leo, Hong Kai Lee, Xinrui Zhou
Publikováno v: International Journal of Infectious Diseases, Vol 90, Iss, Pp 84-96 (2020)
Background: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular evolution and receptor-binding specificit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4236c672542228992d49dde8169bf832
http://www.sciencedirect.com/science/article/pii/S1201971219304175
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9
Akademický článek
Molecular surveillance of antiviral drug resistance of influenza A/H3N2 virus in Singapore, 2009-2013.
Autor: Hong Kai Lee, Julian Wei-Tze Tang, Tze Ping Loh, Aeron C Hurt, Lynette Lin-Ean Oon, Evelyn Siew-Chuan Koay
Publikováno v: PLoS ONE, Vol 10, Iss 1, p e0117822 (2015)
Adamantanes and neuraminidase inhibitors (NAIs) are two classes of antiviral drugs available for the chemoprophylaxis and treatment of influenza infections. To determine the frequency of drug resistance in influenza A/H3N2 viruses in Singapore, large
Externí odkaz: https://doaj.org/article/9a92293dafd74570a856f1c4eeffcbb8
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