Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Hong-Jin Shu"'
Autor:
Hong-Jin Shu, Luke H. Ziolkowski, Sofia V. Salvatore, Ann M. Benz, David F. Wozniak, Carla M. Yuede, Steven M. Paul, Charles F. Zorumski, Steven Mennerick
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 254 (2024)
Brain cholesterol metabolic products include neurosteroids and oxysterols, which play important roles in cellular physiology. In neurons, the cholesterol oxidation product, 24S-hydroxycholesterol (24S-HC), is a regulator of signaling and transcriptio
Externí odkaz:
https://doaj.org/article/8f64cddbe0f843c7a857f9ccbff220df
Autor:
Hong-Jin Shu, Xinguo Lu, John Bracamontes, Joe Henry Steinbach, Charles F. Zorumski, Steven Mennerick
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
GABAA receptors (GABAARs) play a crucial role in inhibition in the central nervous system. GABAARs containing the δ subunit mediate tonic inhibition, have distinctive pharmacological properties and are associated with disorders of the nervous system
Externí odkaz:
https://doaj.org/article/2d6c80293f0b4718b46de2d30e9260f4
Autor:
Michael Popiolek, Yukitoshi Izumi, Allen T. Hopper, Jing Dai, Silke Miller, Hong-Jin Shu, Charles F. Zorumski, Steven Mennerick
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The manipulation of cholesterol and its metabolites has been hypothesized to be therapeutically beneficial for mood disorders, neurodegenerative disorders, and epilepsies. A major regulator of cholesterol clearance and turnover in the central nervous
Externí odkaz:
https://doaj.org/article/ffed4e08c8dc4a30a0bd6a345a5dfdf8
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195520 (2018)
Neurons require a nearly constant supply of ATP. Glucose is the predominant source of brain ATP, but the direct effects of prolonged glucose deprivation on neuronal viability and function remain unclear. In sparse rat hippocampal microcultures, neuro
Externí odkaz:
https://doaj.org/article/b5b410d8bef348208b6c20593e378a28
Autor:
Steven Mennerick, Isaac Mordukhovich, Charles F. Zorumski, Peter M. Lambert, Daniel M. Chen, Mingxing Qian, Luke Ziolkowski, Mariangela Chisari, Douglas F. Covey, Hong Jin Shu
Neuroactive steroids are an ascendant class of treatment for neuropsychiatric illness. Effects on ligand-gated neurotransmitter receptors appear to be a major mechanism of action. Here we describe a neuroactive steroid with a unique constellation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622b0c993952e1925afc6f74d4d17d32
https://hdl.handle.net/20.500.11769/552026
https://hdl.handle.net/20.500.11769/552026
Autor:
Steven Mennerick, Michael Popiolek, Allen T. Hopper, Silke Miller, Jing Dai, Yukitoshi Izumi, Charles F. Zorumski, Hong Jin Shu
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The manipulation of cholesterol and its metabolites has been hypothesized to be therapeutically beneficial for mood disorders, neurodegenerative disorders, and epilepsies. A major regulator of cholesterol clearance and turnover in the central nervous
Autor:
Luke, Ziolkowski, Isaac, Mordukhovich, Daniel M, Chen, Mariangela, Chisari, Hong-Jin, Shu, Peter M, Lambert, Mingxing, Qian, Charles F, Zorumski, Douglas F, Covey, Steven, Mennerick
Publikováno v:
Neuropharmacology
Neuroactive steroids are an ascendant class of treatment for neuropsychiatric illness. Effects on ligand-gated neurotransmitter receptors appear to be a major mechanism of action. Here we describe a neuroactive steroid with a unique constellation of
Autor:
John Bracamontes, Ann Benz, Steven Mennerick, Min-Yu Sun, Gustav Akk, Charles F. Zorumski, Joe Henry Steinbach, Hong-Jin Shu
Publikováno v:
The Journal of Neuroscience. 38:8128-8145
Two major GABAAreceptor classes mediate ionotropic GABA signaling, those containing a δ subunit and those with a γ2 subunit. The classical viewpoint equates γ2-containing receptors with IPSCs and δ-containing receptors with tonic inhibition becau
Autor:
Monika Martinek, Natasha Warikoo, Steven Mennerick, Min-Yu Sun, Luke Ziolkowski, Michael Wong, John Bracamontes, Ann Benz, Hong Jin Shu, Micah Keiser, Joe Henry Steinbach, Charles F. Zorumski, Carson Platnick, Gustav Akk, Peter M. Lambert, Nicholas Rensing
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Pentameric GABAA receptors mediate a large share of CNS inhibition. The γ2 subunit is a typical constituent. At least 11 mutations in the γ2 subunit cause human epilepsies, making the role of γ2-containing receptors in brain function of keen basic
Autor:
Hong-Jin Shu, Laura Piccio, Charles F. Zorumski, Gregory S. Day, Samuel J. Brunwasser, Steven M. Paul, Mike Lewis, James J. Doherty, Ann Benz, Steven Mennerick, Michael Quirk, Natasha Warikoo
Publikováno v:
The Journal of Neuroscience. 38:3218-3229
N-methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors important for synaptic plasticity, memory, and neuropsychiatric health. NMDAR hypofunction contributes to multiple disorders, including anti-NMDAR encephalitis (NMDARE), an au