Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Hong-Jai Park"'
Autor:
Juan Joseph Young, Hong-Jai Park, Minhyung Kim, Jennefer Par-Young, Hugh Bartlett, Hye Sun Kim, Serhan Unlu, Lais Osmani, Min Sun Shin, Richard Bucala, Christopher H. van Dyck, Heather Allore, Adam P. Mecca, Sungyong You, Insoo Kang
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T cells expressing low levels of IL-7 receptor alpha (IL-7Rαlow) and the presence of its gene signature (i.e
Externí odkaz:
https://doaj.org/article/cfa2d915209747c0a4d52c103cb96478
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-8 (2022)
Abstract CD8+ T cells play an important role in host defense against infections and malignancies as well as contribute to the development of inflammatory disorders. Alterations in the frequency of naïve and memory CD8+ T cells are one of the most si
Externí odkaz:
https://doaj.org/article/0b61ff84b77243c6b12ddad85cfd8d87
Publikováno v:
International Journal of Cardiology Congenital Heart Disease, Vol 8, Iss , Pp 100359- (2022)
Introduction: T cells developed in the thymus play a key role in vaccine immunity. Thymectomy occurs during infant congenital heart surgery and results in an altered T cell distribution. We investigated if adults with congenital heart disease (ACHD)
Externí odkaz:
https://doaj.org/article/86f64c323e24447ab3baa4b9291ca164
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Checkpoint inhibitors have demonstrated clinical impact in colorectal cancer with deficient mismatch repair and high microsatellite instability. However, the majority of patients have disease with stable microsatellites that responds poorly
Externí odkaz:
https://doaj.org/article/c3f1eaec71aa4d68a08a5f210792e245
Autor:
Hong-Jai Park, Sunjin Boo, Inkeun Park, Min Sun Shin, Tsukasa Takahashi, Jun Takanari, Kohei Homma, Insoo Kang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Treatment strategies combining immune checkpoint blockade (ICB) with other agents have emerged as a promising approach in the treatment of cancers. AHCC®, a standardized extract of cultured Lentinula edodes mycelia, has been reported to inhibit tumo
Externí odkaz:
https://doaj.org/article/483db17a25824b3a91d6c248d02c72dc
Autor:
Do-Hyun Kim, Hong-Jai Park, Hyeon-Soo Park, Jae-Ung Lee, CheMyong Ko, Myung Chan Gye, Je-Min Choi
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 4, Pp 1-9 (2019)
Autoimmune disease: the importance of estrogen Estrogen signaling may play a crucial role in mediating autoimmune responses and preventing diseases such as rheumatoid arthritis. Estrogen plays vital roles in the female endocrine and reproductive syst
Externí odkaz:
https://doaj.org/article/d230eeb9d44a4fc2938f0eefdc0632f8
Autor:
Do-Hyun Kim, Hong-Jai Park, Sangho Lim, Ja-Hyun Koo, Hong-Gyun Lee, Jin Ouk Choi, Ji Hoon Oh, Sang-Jun Ha, Min-Jong Kang, Chang-Min Lee, Chun Geun Lee, Jack A. Elias, Je-Min Choi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Chitinase-3-like-1 (Chi3l1) has been involved in inflammation and pulmonary metastasis. Here the authors show that Chi3l1 inhibits the T cell response by negatively regulating their activation and that, in a mouse model of melanoma, T cell-targeted s
Externí odkaz:
https://doaj.org/article/278c64fb54e544eda2674e6aee00955b
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
Mushrooms have been used for various health conditions for many years by traditional medicines practiced in different regions of the world although the exact effects of mushroom extracts on the immune system are not fully understood. AHCC® is a stan
Externí odkaz:
https://doaj.org/article/d64d8066780d430e8ea7f74c76a68a5e
Autor:
Hong-Jai Park, Do-Hyun Kim, Jin-Young Choi, Won-Ju Kim, Ji Yun Kim, Alireza G Senejani, Soo Seok Hwang, Lark Kyun Kim, Zuzana Tobiasova, Gap Ryol Lee, Joseph Craft, Alfred L M Bothwell, Je-Min Choi
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99127 (2014)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that regulates lipid and glucose metabolism. Although studies of PPARγ ligands have demonstrated its regulatory functions in inflammation and adaptive immunity, its
Externí odkaz:
https://doaj.org/article/ded578c19adc4d8ba998f3895c01a705
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 8, p 1347 (2016)
Peroxisome proliferator-activated receptor gamma (PPARγ) has recently been recognized to regulate adaptive immunity through Th17 differentiation, Treg functions, and TFH responses. However, its role in adaptive immunity and autoimmune disease is sti
Externí odkaz:
https://doaj.org/article/506bd9ae00de40aab451e3df3fd6d0d3