Výsledky vyhledávání - "Hong-Gyum Kim"

Akademický článek

Computational and Biochemical Discovery of RSK2 as a Novel Target for Epigallocatechin Gallate (EGCG).

Autor: Hanyong Chen, Ke Yao, Xiaoyu Chang, Jung-Hyun Shim, Hong-Gyum Kim, Margarita Malakhova, Dong-Joon Kim, Ann M Bode, Zigang Dong

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130049 (2015)

The most active anticancer component in green tea is epigallocatechin-3-gallate (EGCG). Protein interaction with EGCG is a critical step for mediating the effects of EGCG on the regulation of various key molecules involved in signal transduction. By

Externí odkaz: https://doaj.org/article/237546dfd3834fe691d9896e2234383f

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Akademický článek

Honokiol Inhibits Melanoma Growth by Targeting Keratin 18 in vitro and in vivo

Autor: Tingting Liu, Hui Liu, Penglei Wang, Yamei Hu, Ran Yang, Fangfang Liu, Hong Gyum Kim, Zigang Dong, Kangdong Liu

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Honokiol, a natural compound, derived from Magnolia officinalis, has been shown to have anti-cancer effect in several cancer types. However, the underlying molecular mechanism associated with its anti-cancer properties has not been fully elucidated.

Externí odkaz: https://doaj.org/article/02fd30b4ad8a4a9b9c0bdc0cd8512834

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Supplemental Figure 1 from Kaempferol Targets RSK2 and MSK1 to Suppress UV Radiation-Induced Skin Cancer

Autor: Zigang Dong, Ziming Dong, Ann M. Bode, Wei-Ya Ma, Hong-Gyum Kim, Ki Beom Bae, Haitao Li, Mee-Hyun Lee, Myoung Ok Kim, Dong Hoon Yu, Yi Zhang, Ge Yang, Alyssa Langfald, Kangdong Liu, Hanyong Chen, Ke Yao

SUV induces MAP kinase phosphorylation in JB6 P+ mouse epidermal skin cells in a time- or dose-dependent manner. (A) JB6 P+ cells were cultured, treated with SUV (60 kJ/m2) and harvested at the times indicated (0, 15, 30, 60, or 120 min). (B) JB6 P+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3f189fdc0fb4fc31953e00c147c161
https://doi.org/10.1158/1940-6207.22524800

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Supplemental Figure 3 from Kaempferol Targets RSK2 and MSK1 to Suppress UV Radiation-Induced Skin Cancer

(A) Kinase screening assays were conducted by Millipore's KinaseProfiler according to their established protocols. Scores represent the percent of control, which was derived from the following formula: % of control = [(sample âˆ’ mean no enzyme)/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057d18df944fd7ed07078cd1de184a64
https://doi.org/10.1158/1940-6207.22524794.v1

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Data from Targeting PRPK Function Blocks Colon Cancer Metastasis

Autor: Zigang Dong, Ann M. Bode, Weiya Ma, Yan Li, Janos Nadas, Seung Ho Shin, Weihong Wen, Ki Beom Bae, Hong-Gyum Kim, Sang-Pil Yoon, Eunmiri Roh, Ke Yao, Do Young Lim, Haitao Li, Lei Wang, Feng Zhu, Tatyana Zykova

The biological functions of the p53-related protein kinase (PRPK) remain unclear. We have previously demonstrated that PRPK is phosphorylated by the T-LAK cell-originated protein kinase (TOPK) and that phosphorylated PRPK (p-PRPK) promotes colon canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4366b22e5e9ff4cf4c43fc5be5797c32
https://doi.org/10.1158/1535-7163.c.6537850.v1

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Supplemental Figure 2 from Kaempferol Targets RSK2 and MSK1 to Suppress UV Radiation-Induced Skin Cancer

RSK2 and MSK1 play an important role in Ras-mediated foci formation. A focus formation assay was performed by introducing combinations of vectors as indicated. Foci were stained with 0.5% crystal violet and counted under a microscope using the Image-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15677a86d1ba0ee2391c82dd00df3a1a
https://doi.org/10.1158/1940-6207.22524797.v1

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