Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Hong-Bing S"'
Autor:
Shan Su, Duo Hua, Jin-Peng Li, Xia-Nan Zhang, Lei Bai, Li-Bo Cao, Yi Guo, Ming Zhang, Jia-Zhen Dong, Xiao-Wei Liang, Ke Lan, Ming-Ming Hu, Hong-Bing Shu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Whether and how innate antiviral response is regulated by humoral metabolism remains enigmatic. We show that viral infection induces progesterone via the hypothalamic-pituitary-adrenal axis in mice. Progesterone induces downstream antiviral
Externí odkaz:
https://doaj.org/article/a7a982087ef54da1a75415abf94a99d1
Autor:
Wenjun Xiong, Xueliang Gao, Tiantian Zhang, Baishan Jiang, Ming-Ming Hu, Xia Bu, Yang Gao, Lin-Zhou Zhang, Bo-Lin Xiao, Chuan He, Yishuang Sun, Haiou Li, Jie Shi, Xiangling Xiao, Bolin Xiang, Conghua Xie, Gang Chen, Haojian Zhang, Wenyi Wei, Gordon J. Freeman, Hong-Bing Shu, Haizhen Wang, Jinfang Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The regulatory mechanisms of PD-L1 posttranslational modifications are not completely understood. Here the authors show that USP8 negatively regulates PD-L1 protein abundance by removing the K63-linked ubiquitination of PD-L1; while USP8 inhibition i
Externí odkaz:
https://doaj.org/article/e769071990584a6aa031c02542686ae3
Autor:
Lu Feng, Chen Li, Lin-Wen Zeng, Deng Gao, Yu-Hao Sun, Li Zhong, Heng Lin, Hong-Bing Shu, Shu Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-12 (2022)
Abstract Interleukin-3 (IL-3) is a hematopoietic growth factor and critical regulator of inflammatory response such as sepsis. IL-3 binds to IL-3 receptor α (IL-3Rα), which is then associated with IL-3Rβ to initiate signaling. How IL-3-triggered p
Externí odkaz:
https://doaj.org/article/da66a388dcff41cda067d8c04f442f3a
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
An increase in glycine decarboxylase (GLDC) activity, a key enzyme for glycine catabolism, has been associated to tumourigenesis. Here, the authors show that mTORC1 activation induces GLDC deacetylation which impairs its ubiquitin-associated degradat
Externí odkaz:
https://doaj.org/article/3e8e2ec8a90b413e8b695cd802a92e8f
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract MITA (also known as STING) is an ER-located adaptor protein, which mediates DNA-triggered innate immune response and is critically involved in autoimmune diseases and tumorigenesis. MITA is regulated by post-translational modifications, but
Externí odkaz:
https://doaj.org/article/6f19ecee91604a91bd9a3077f189b38c
Autor:
Xiaona Sun, Ting Liu, Jun Zhao, Hansong Xia, Jun Xie, Yu Guo, Li Zhong, Mi Li, Qing Yang, Cheng Peng, Isabelle Rouvet, Alexandre Belot, Hong-Bing Shu, Pinghui Feng, Junjie Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.
Externí odkaz:
https://doaj.org/article/4244008ca6074117babe9a1796cb68c8
Publikováno v:
Infectious Diseases of Poverty, Vol 9, Iss 1, Pp 1-13 (2020)
Abstract Background Coronavirus disease 2019 (COVID-19) has caused a serious epidemic around the world, but it has been effectively controlled in the mainland of China. The Chinese government limited the migration of people almost from all walks of l
Externí odkaz:
https://doaj.org/article/f11e88dc91674cf6b08f8deb3f9c474b
Publikováno v:
Chinese Medical Journal, Vol 133, Iss 9, Pp 1073-1079 (2020)
Abstract. Background. Excessive inflammatory responses play a critical role in the development of severe acute pancreatitis (SAP), and controlling such inflammation is vital for managing this often fatal disease. Dexmedetomidine has been reported to
Externí odkaz:
https://doaj.org/article/7045b62a730b45b9988ce995d6abcc0b
Autor:
Mi Li, Hong-Bing Shu
Publikováno v:
Protein & Cell, Vol 11, Iss 8, Pp 584-599 (2020)
Abstract The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize c
Externí odkaz:
https://doaj.org/article/0d8d4ed4222641d2936c173e8d2ddfd8
Autor:
Hong-Bing Shu
Publikováno v:
Cell Insight, Vol 1, Iss 1, Pp 100006- (2022)
Externí odkaz:
https://doaj.org/article/5eafa78843b144c0b72fcf11fc316325