Výsledky vyhledávání - "Hong Y. Wang"

Akademický článek

ACLY is the novel signaling target of PIP2/PIP3 and Lyn in acute myeloid leukemia

Autor: Johnvesly Basappa, Mevlut Citir, Qian Zhang, Hong Y. Wang, Xiaobin Liu, Olga Melnikov, Hafiz Yahya, Frank Stein, Rainer Muller, Alexis Traynor-Kaplan, Carsten Schultz, Mariusz A. Wasik, Andrzej Ptasznik

Publikováno v: Heliyon, Vol 6, Iss 5, Pp e03910- (2020)

A fundamental feature of tumor progression is reprogramming of metabolic pathways. ATP citrate lyase (ACLY) is a key metabolic enzyme that catalyzes the generation of Acetyl-CoA and is upregulated in cancer cells and required for their growth. The ph

Externí odkaz: https://doaj.org/article/a6299949ea754bc2954c360ced29c4b7

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Akademický článek

Dynamic Changes in Gene Mutational Landscape With Preservation of Core Mutations in Mantle Cell Lymphoma Cells

Autor: Qian Zhang, Hong Y. Wang, Xiaobin Liu, Michael H. Roth, Alex A. Shestov, Seung-Cheol Lee, Kanika Jain, Craig Soderquist, Qun-Bin Xiong, Marco Ruella, Honore Strauser, Jerry D. Glickson, Stephen J. Schuster, Andrzej Ptasznik, Mariusz A. Wasik

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

While studies have identified a number of mutations in mantle cell lymphoma (MCL), the list may still be incomplete and contribution to the pathogenesis remains unclear. We analyzed the mutational landscape of four mantle cell lymphoma biopsies obtai

Externí odkaz: https://doaj.org/article/94ab3fa20f4f4f478be377905a6e59a4

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Induction of Transcriptional Inhibitor HES1 and the Related Repression of Tumor-Suppressor TXNIP Are Important Components of Cell-Transformation Program Imposed by Oncogenic Kinase NPM-ALK

Autor: Qian Zhang, Hong Y. Wang, Anindita Nayak, Selene Nunez-Cruz, Artur Slupianek, Xiaobin Liu, Johnvesly Basappa, Jing-Song Fan, Seble Chekol, Reza Nejati, Agata M. Bogusz, Suzanne D. Turner, Kunchithapadam Swaminathan, Mariusz A. Wasik

Publikováno v: The American Journal of Pathology. 192:1186-1198

This study reports that hairy and enhancer of split homolog-1 (HES1), known to repress gene transcription in progenitor cells of several cell lineages, was strongly expressed in cells and tissues of T-cell lymphoma expressing the oncogenic chimeric t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7b59cd3824df707d344b6dc115a79e
https://doi.org/10.1016/j.ajpath.2022.05.005

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NPM–ALK-Induced Reprogramming of Mature TCR-Stimulated T Cells Results in Dedifferentiation and Malignant Transformation

Autor: Qian Zhang, John K. Everett, Hong Kong, Damian Maseda, Kelly Zullo, Fang Wei, James L. Riley, John W. Tobias, Mariusz A. Wasik, Jan M. Pawlicki, David L. Cookmeyer, Amanda A. Watkins, Hong Y. Wang, Frederic D. Bushman, Sarah Javaid, David M. Walter

Publikováno v: Cancer Research. 81:3241-3254

Fusion genes including NPM–ALK can promote T-cell transformation, but the signals required to drive a healthy T cell to become malignant remain undefined. In this study, we introduce NPM–ALK into primary human T cells and demonstrate induction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6385967faea9f5f09070a4e4293408
https://doi.org/10.1158/0008-5472.can-20-2297

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ACLY is the Novel Signaling Target of PIP 2/PIP 3 and Lyn in Cancer

Autor: Olga Melnikov, Frank Stein, Mevlut Citir, Johnvesly Basappa, Hong Y. Wang, Andrzej Ptasznik, Carsten Schultz, Qian Zhang, Rainer Müller, Mariusz A. Wasik, Hafiz Yahya, Xiaobin Liu, Alexis Traynor-Kaplan

Publikováno v: SSRN Electronic Journal.

ATP citrate lyase (ACLY) is a key metabolic enzyme that catalyzes the generation of Acetyl-CoA and is upregulated in cancer cells and required for their growth. The phosphoinositide 3-kinase (PI3K) and Src-family kinase (SFK) Lyn are constitutively a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76eac56966a3a3fefffaa0dc863b73b8
https://doi.org/10.2139/ssrn.3520242

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Neutrophil-to-Lymphocyte Ratio Improves the Accuracy and Sensitivity of Pneumonia Severity Index in Predicting 30-Day Mortality of CAP Patients

Publikováno v: Clinical laboratory. 65(10)

Background The pneumonia severity index (PSI) scoring system is one of the tools used to evaluate and predict the prognosis of patients with community-acquired pneumonia (CAP). Although PSI has been widely used in clinical studies of pneumonia, it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32350134f06453879a4cc097a097248e
https://pubmed.ncbi.nlm.nih.gov/31625349

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Elevated Adenosine Dehydrogenase (ADH) and Positive Tuberculin Test Firstly Misdiagnosed as Tuberculous Pleural Effusion Finally Proved as Pleural Mesothelial Sarcoma by Thoracoscopic Biopsy Pathology: a Case Report and Literature Review

Autor: Yan L Ge, Meng H Wang, Xiao Y Zhu, Qian Zhang, Yi Chen, Dong F Shao, Wen Q Li, Hong Y Wang, Ai S Fu, Ci Zhang

Publikováno v: Clinical laboratory. 65(10)

Background In China, tuberculous pleural effusion is the most common cause for pleural effusion. Elevated ADH and positive tuberculin test usually are characteristic of tuberculous pleural effusion. We reported a 71-year-old male patient with elevate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316947bd1922f8bfa58fad5f6d2dcd8e
https://pubmed.ncbi.nlm.nih.gov/31625358

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