Zobrazeno 1 - 10
of 477
pro vyhledávání: '"Hong Wei Chu"'
Autor:
Jamie L. Everman, Satria P. Sajuthi, Maude A. Liegeois, Nathan D. Jackson, Erik H. Collet, Michael C. Peters, Maurizio Chioccioli, Camille M. Moore, Bhavika B. Patel, Nathan Dyjack, Roger Powell, Cydney Rios, Michael T. Montgomery, Celeste Eng, Jennifer R. Elhawary, Angel C. Y. Mak, Donglei Hu, Scott Huntsman, Sandra Salazar, Luigi Feriani, Ana Fairbanks-Mahnke, Gianna L. Zinnen, Cole R. Michel, Joe Gomez, Xing Zhang, Vivian Medina, Hong Wei Chu, Pietro Cicuta, Erin D. Gordon, Pamela Zeitlin, Victor E. Ortega, Nichole Reisdorph, Eleanor M. Dunican, Monica Tang, Brett M. Elicker, Travis S. Henry, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, Elliot Israel, Bruce D. Levy, David T. Mauger, Deborah A. Meyers, Kaharu Sumino, David S. Gierada, Annette T. Hastie, Wendy C. Moore, Loren C. Denlinger, Nizar N. Jarjour, Mark L. Schiebler, Sally E. Wenzel, Prescott G. Woodruff, Jose Rodriguez-Santana, Chad G. Pearson, Esteban G. Burchard, John V. Fahy, Max A. Seibold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical si
Externí odkaz:
https://doaj.org/article/e5fbd453726447a6a3e42371a05beeb5
Autor:
Niccolette Schaunaman, Diana Cervantes, Taylor Nichols, Mari Numata, Julie G. Ledford, Monica Kraft, Hong Wei Chu
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Influenza A virus (IAV) infection is a significant risk factor for respiratory diseases, but the host defense mechanisms against IAV remain to be defined. Immune regulators such as surfactant protein A (SP-A) and Toll-interacting
Externí odkaz:
https://doaj.org/article/26b89ed4812d46e2a7acb45c35eab12b
Autor:
Sasipa Tanyaratsrisakul, Yury A. Bochkov, Vanessa White, Heejung Lee, Jessica Loeffler, Jamie Everman, Allison M. Schiltz, Kristy L. Freeman, Katharine L. Hamlington, Elizabeth A. Secor, Nathan D. Jackson, Hong Wei Chu, Andrew H. Liu, Julie G. Ledford, Monica Kraft, Max A. Seibold, Dennis R. Voelker, Mari Numata
Publikováno v:
Viruses, Vol 16, Iss 11, p 1709 (2024)
Rhinovirus C (RV-C) infection can trigger asthma exacerbations in children and adults, and RV-C-induced wheezing illnesses in preschool children correlate with the development of childhood asthma. Surfactant protein A (SP-A) plays a critical role in
Externí odkaz:
https://doaj.org/article/48384951f38c4b7a9cce62d4e3724c43
Autor:
Niccolette Schaunaman, Taylor Nichols, Diana Cervantes, Paige Hartsoe, Deborah A. Ferrington, Hong Wei Chu
Publikováno v:
Viruses, Vol 16, Iss 9, p 1384 (2024)
Allergic asthma is characterized by increased type 2 inflammation, including eosinophils. Subjects with allergic asthma have recurrent symptoms due to their constant exposure to environmental allergens, such as house dust mite (HDM), which can be fur
Externí odkaz:
https://doaj.org/article/4c6e1fbbe59b4afc8ce1ba394eadfdf5
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Toll-interacting protein (Tollip) is a negative regulator of the pro-inflammatory response to viruses, including influenza A virus (IAV). Genetic variation of Tollip has been associated with reduced airway epithelial Tollip expression and poor lung f
Externí odkaz:
https://doaj.org/article/49e159cdb5ee4b37aeb3b383baabe073
Autor:
Taylor Crue, Grace Yihua Lee, Joyce Yao-chun Peng, Niccolette Schaunaman, Hina Agraval, Brian J. Day, Kris Genelyn Dimasuay, Diana Cervantes, Hamid Nouri, Taylor Nichols, Paige Hartsoe, Mari Numata, Irina Petrache, Hong Wei Chu
Publikováno v:
Innate Immunity, Vol 29 (2023)
Vaping is an increasing health threat in the US and worldwide. The damaging impact of vaping on the human distal lung has been highlighted by the recent epidemic of electronic cigarette or vaping use-associated lung injury (EVALI). The pathogenesis o
Externí odkaz:
https://doaj.org/article/32325d546c74465ca09779b17b12324e
Autor:
Kris Genelyn Dimasuay, Niccolette Schaunaman, Bruce Berg, Diana Cervantes, Elke Kruger, Frank L. Heppner, Deborah A. Ferrington, Hong Wei Chu
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Immunoproteasomes (IP) serve as an important modulator of immune responses to pathogens and other pathological factors. LMP7/β5i, one of the IP subunits, plays a critical role in autoimmune diseases by downregulating inflammation. Rhinoviru
Externí odkaz:
https://doaj.org/article/4dca76a769574fdeb2b6694c152d344a
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionDeployment related asthma-like symptoms including distal airway obstruction have been described in U.S. military personnel who served in Iraq and Afghanistan. The mechanisms responsible for the development of distal airway obstruction in
Externí odkaz:
https://doaj.org/article/93ca73984a8c40ada2c0b1d066b9ad05
Autor:
Kris Genelyn Dimasuay, Bruce Berg, Niccolette Schaunaman, Fernando Holguin, Daniel Winnica, Hong Wei Chu
Publikováno v:
Frontiers in Allergy, Vol 4 (2023)
IntroductionMetabolic dysfunction such as elevated levels of saturated fatty acids (SFA) may play a role in obese asthma, but its contribution to airway inflammation remains unclear. We sought to determine the role of high-fat diet (HFD) and palmitic
Externí odkaz:
https://doaj.org/article/450e2aea6539423786c59e27f3ef4bcd
Autor:
Niccolette Schaunaman, Kris Genelyn Dimasuay, Diana Cervantes, Liwu Li, Mari Numata, Monica Kraft, Hong Wei Chu
Publikováno v:
Journal of Innate Immunity, Pp 1-11 (2022)
Respiratory influenza A virus (IAV) infection continues to pose significant challenges in healthcare of human diseases including asthma. IAV infection in mice was shown to increase IL-33, a key cytokine in driving airway inflammation in asthma, but h
Externí odkaz:
https://doaj.org/article/228b3aa1d13240868675d52748f250d0